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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Biology, Medicine, & Natural Product Chemistry Indonesian Journal of Life Sciences
Rahma, Adinda Aulia
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Prediction of Artocarpus altilis Potential as an Anti Breast Cancer by Inhibiting EGFR: a Molecular Docking Study Farid, Muhammad; Rastrani, Ardestya; Rahma, Adinda Aulia; Ramadhania, Widya Aryana
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.199-204

Abstract

Reseptor Faktor Pertumbuhan Epidermal (EGFR) merupakan target penting dalam terapi kanker payudara, mengingat perannya dalam proliferasi, motilitas, dan invasi sel tumor melalui jalur pensinyalan penting seperti Ras-MAPK dan PI3K/Akt. Penelitian ini mengeksplorasi potensi senyawa aktif Artocarpus altilis (AA), yang kaya akan flavonoid, sebagai alternatif kemoterapi. Metode docking molekular digunakan untuk memprediksi interaksi antara senyawa AA dan protein EGFR (PDB ID: 2J6M). Validasi docking menunjukkan nilai RMSD sebesar 0,854 Å, yang menunjukkan akurasi tinggi. Asam ellagic menunjukkan afinitas pengikatan terbaik (-8,4 kkal/mol), diikuti oleh Quercetin (-7,3 kkal/mol), Katekin, dan Epikatekin (-7,2 kkal/mol). Analisis residu mengungkapkan bahwa MET793 memainkan peran kunci dalam stabilitas interaksi. Visualisasi interaksi dan prediksi ADMET menunjukkan bahwa sebagian besar senyawa memenuhi Aturan Lima Lipinski, tanpa risiko hepatotoksisitas atau mutagenesis. Senyawa potensial seperti Quercetin dan Epicatechin menunjukkan kinerja yang sebanding dengan doxorubicin, tetapi dengan potensi efek samping yang lebih rendah. Hasil ini memperkuat peran senyawa alami sebagai kandidat untuk terapi kanker yang ditargetkan pada EGFR, yang menyediakan dasar untuk pengembangan obat antikanker yang lebih aman dan lebih efektif.
Chub mackerel as potential lipid-based functional food Sode Muda, Eleonora Valentia; Rahma, Adinda Aulia; Jonathan, Brian; Chandra, Jefferson Nathanael; Liony, Jessica Michelle; Kuntadi, Muhammad Fajar; Astina, Junaida
Indonesian Journal of Life Sciences 2025: IJLS Vol 07 No.02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v7i02.207

Abstract

Functional foods have gained a lot of attention as people become more aware of the importance of human nutrition. Chub mackerel is classified as one of the functional foods due to being rich in omega-3 fatty acids, which include eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) that are associated with various health benefits, including anti-inflammatory properties, cardiovascular health support, and cognitive function enhancement. Additionally, chub mackerel also contains high protein, vitamin, and mineral content that contribute to muscle growth, immune system support, and cognitive function improvement. Research has indicated the safety and efficacy of consuming omega-3 from chub mackerel, particularly among vulnerable populations like pregnant women and children. Various processing techniques have been applied to chub mackerel to enhance its quality as a functional food, including roasting and frying. However, non-thermal processing may better preserve the nutritional compositions, mitigating nutrient losses during processing. The future outlook for chub mackerel as a functional food includes further research into alternative cooking methods to preserve omega-3 content and the implementation of regulatory measures and industry collaborations to promote its utilization as a functional food, particularly in regions like Indonesia where it is abundant and affordable. Overall, chub mackerel shows promise as a lipid-based functional food with significant potential for improving public health and addressing the rising prevalence of non-communicable diseases.
Bioinformatics Analysis to Identify Therapeutic Targets of Artocarpus altilis Compounds in Breast Cancer Therapy Farid, Muhammad; Dewi, Fitria Puspita; Ramadhania, Widya Aryana; Rastrani, Ardestya; Rahma, Adinda Aulia
Media Farmasi: Jurnal Ilmu Farmasi Vol. 22 No. 2 (2025): September 2025
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v22i2.31075

Abstract

Breast cancer remains the most prevalent malignancy among women worldwide, with approximately 2.3 million new cases and 685,000 deaths reported in 2020. Despite advances in surgery, chemotherapy, radiotherapy, endocrine, and targeted therapies, these treatments are often limited by severe side effects and resistance mechanisms. Artocarpus altilis a medicinal plant rich in flavonoids and other bioactive compounds, has been traditionally utilized in various therapeutic contexts and is increasingly recognized for its anticancer potential. This study aimed to systematically identify the molecular targets and signaling pathways associated with A. Artocarpus altilis in breast cancer using a network pharmacology approach, thereby providing novel insights into its therapeutic relevance. The in-silico analysis integrated compound screening, drug-likeness evaluation, target protein prediction, protein–protein interaction mapping, Gene Ontology enrichment, and KEGG pathway analysis. Among 14 candidate compounds, three exhibited poor pharmacokinetic properties based on Lipinski’s Rule of Five. A total of 16 breast cancer-related protein targets were identified, with Epidermal Growth Factor Receptor (EGFR) and Insulin-like Growth Factor 1 Receptor (IGF1R) emerging as the most significant hubs. Functional enrichment revealed that these targets participate in critical oncogenic pathways, including PI3K/Akt, MAPK, and JAK/STAT signaling, which are strongly associated with cell proliferation, migration, and metastasis. The findings highlight the central role of EGFR and IGF1R in mediating the pharmacological effects of A. Artocarpus altilis suggesting its potential as a complementary therapeutic candidate in breast cancer management. While this study provides a systematic bioinformatics-based framework for elucidating the molecular mechanisms of A. Artocarpus altilis, further experimental validation in vitro and in vivo is essential to confirm its efficacy and safety.
Co-Authors Chandra, Jefferson Nathanael Dewi, Fitria Puspita Jonathan, Brian Junaida Astina Kuntadi, Muhammad Fajar Liony, Jessica Michelle Muhammad Farid Ramadhania, Widya Aryana Rastrani, Ardestya Sode Muda, Eleonora Valentia