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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Biology, Medicine, & Natural Product Chemistry
Rastrani, Ardestya
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Inhibitory effects of rambutan (Nephelium lappaceum l.) leaves ethanolic extract on Methicillin-Resistant Staphylococcus aureus (MRSA) and Streptococcus pyogenes Rizkita, Leonny Dwi; Ariani, Rizka; Farid, Muhammad; Rastrani, Ardestya; Ramadhania, Widya Aryana; Putri, Ratna Aprillia Eka
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 15, No 2 (2024): December 2024
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v15i2.40155

Abstract

Antimicrobial resistance poses a global health threat, with Methicillin-Resistant Staphylococcus aureus (MRSA) and Streptococcus pyogenes contributing to the highest mortality rates among Gram-positive pathogens over the last three decades. The search for alternative antimicrobial agents has increasingly concentrated on natural products. Rambutan (Nephelium lappaceum L.), a widely used ethnomedicinal plant in Indonesia, is recognized for its numerous health benefits, including its antimicrobial properties. Despite extensive phytochemical studies on various parts of rambutan, the specific inhibitory effects of its leaf extract against MRSA and S. pyogenes have yet to be explored. This study aimed to evaluate the antimicrobial activity of ethanolic rambutan leaf extract against MRSA and S. pyogenes. The extract was prepared using maceration with 96% ethanol, followed by qualitative phytochemical screening, which confirmed the presence of flavonoids (blackish-blue reaction with FeCl3) and tannins (reddish hue with HCl). Antibacterial activity was assessed by measuring inhibition zones on agar plates and determining the minimum inhibitory concentration (MIC) through UV-vis spectrophotometry. The 100% ethanolic extract demonstrated significant inhibitory effects, with a mean inhibition zone of 14.6 mm against MRSA, outperforming the 5% (p = 0.0004) and 10% (p = 0.0402) concentrations. For S. pyogenes, the 100% extract produced the largest inhibition zone (24 mm), showing superior activity compared to the 5% (p = 0.0005) and 10% (p = 0.0485) concentrations. MIC analysis indicated optimal antimicrobial activity at both 50% and 100% concentrations for the two pathogens. These findings underscore the potential of rambutan leaf extract as a natural antimicrobial agent against resistant Gram-positive bacteria, warranting further investigation into its bioactive compounds and mechanisms of action.
Prediction of Artocarpus altilis Potential as an Anti Breast Cancer by Inhibiting EGFR: a Molecular Docking Study Farid, Muhammad; Rastrani, Ardestya; Rahma, Adinda Aulia; Ramadhania, Widya Aryana
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.199-204

Abstract

Reseptor Faktor Pertumbuhan Epidermal (EGFR) merupakan target penting dalam terapi kanker payudara, mengingat perannya dalam proliferasi, motilitas, dan invasi sel tumor melalui jalur pensinyalan penting seperti Ras-MAPK dan PI3K/Akt. Penelitian ini mengeksplorasi potensi senyawa aktif Artocarpus altilis (AA), yang kaya akan flavonoid, sebagai alternatif kemoterapi. Metode docking molekular digunakan untuk memprediksi interaksi antara senyawa AA dan protein EGFR (PDB ID: 2J6M). Validasi docking menunjukkan nilai RMSD sebesar 0,854 Å, yang menunjukkan akurasi tinggi. Asam ellagic menunjukkan afinitas pengikatan terbaik (-8,4 kkal/mol), diikuti oleh Quercetin (-7,3 kkal/mol), Katekin, dan Epikatekin (-7,2 kkal/mol). Analisis residu mengungkapkan bahwa MET793 memainkan peran kunci dalam stabilitas interaksi. Visualisasi interaksi dan prediksi ADMET menunjukkan bahwa sebagian besar senyawa memenuhi Aturan Lima Lipinski, tanpa risiko hepatotoksisitas atau mutagenesis. Senyawa potensial seperti Quercetin dan Epicatechin menunjukkan kinerja yang sebanding dengan doxorubicin, tetapi dengan potensi efek samping yang lebih rendah. Hasil ini memperkuat peran senyawa alami sebagai kandidat untuk terapi kanker yang ditargetkan pada EGFR, yang menyediakan dasar untuk pengembangan obat antikanker yang lebih aman dan lebih efektif.
Investigating Genetic Vulnerability to Environmental Exposures and Associated Lung Diseases: A Bioinformatics Study Farid, Muhammad; Rastrani, Ardestya; Yuska, Shaldhan Bayu
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.717-723

Abstract

Lung diseases induced by environmental exposures such as air pollution, cigarette smoke, and industrial particles remain a significant global health concern, contributing to high morbidity and mortality rates. Genetic variations are known to influence individual responses to environmental exposures, but the molecular mechanisms underlying these interactions are not well understood. This study aims to identify genetic variants, specifically Single Nucleotide Polymorphisms (SNPs), that may increase the risk of lung diseases using a bioinformatics approach. The analysis was conducted by integrating various public genetic databases, including PheWAS, GWAS Catalog, HaploReg v4.2, GTEx Portal, and Ensembl Genome Browser. SNPs were filtered based on p-value < 0.05 and odds ratio (OR) > 1. Missense mutations in selected SNPs were further analyzed for gene expression in lung tissue and distribution across populations. From an initial 151 SNPs, 86 met the statistical criteria, and six were identified as missense variants. Two genes, TNIP1 and PSMB8, showed significantly high expression in lung tissue. SNP rs2071543 in PSMB8 exhibited a strong correlation with increased gene expression and demonstrated notable allele frequency variation across populations. These findings suggest that genetic variations, particularly in PSMB8, may contribute to individual susceptibility to lung diseases induced by environmental exposures. This study highlights the importance of multidatabase analysis in identifying genetic biomarkers and provides a foundation for the development of precision therapies for multifactorial lung diseases.
Bioinformatics Analysis to Identify Therapeutic Targets of Artocarpus altilis Compounds in Breast Cancer Therapy Farid, Muhammad; Dewi, Fitria Puspita; Ramadhania, Widya Aryana; Rastrani, Ardestya; Rahma, Adinda Aulia
Media Farmasi: Jurnal Ilmu Farmasi Vol. 22 No. 2 (2025): September 2025
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v22i2.31075

Abstract

Breast cancer remains the most prevalent malignancy among women worldwide, with approximately 2.3 million new cases and 685,000 deaths reported in 2020. Despite advances in surgery, chemotherapy, radiotherapy, endocrine, and targeted therapies, these treatments are often limited by severe side effects and resistance mechanisms. Artocarpus altilis a medicinal plant rich in flavonoids and other bioactive compounds, has been traditionally utilized in various therapeutic contexts and is increasingly recognized for its anticancer potential. This study aimed to systematically identify the molecular targets and signaling pathways associated with A. Artocarpus altilis in breast cancer using a network pharmacology approach, thereby providing novel insights into its therapeutic relevance. The in-silico analysis integrated compound screening, drug-likeness evaluation, target protein prediction, protein–protein interaction mapping, Gene Ontology enrichment, and KEGG pathway analysis. Among 14 candidate compounds, three exhibited poor pharmacokinetic properties based on Lipinski’s Rule of Five. A total of 16 breast cancer-related protein targets were identified, with Epidermal Growth Factor Receptor (EGFR) and Insulin-like Growth Factor 1 Receptor (IGF1R) emerging as the most significant hubs. Functional enrichment revealed that these targets participate in critical oncogenic pathways, including PI3K/Akt, MAPK, and JAK/STAT signaling, which are strongly associated with cell proliferation, migration, and metastasis. The findings highlight the central role of EGFR and IGF1R in mediating the pharmacological effects of A. Artocarpus altilis suggesting its potential as a complementary therapeutic candidate in breast cancer management. While this study provides a systematic bioinformatics-based framework for elucidating the molecular mechanisms of A. Artocarpus altilis, further experimental validation in vitro and in vivo is essential to confirm its efficacy and safety.
Co-Authors Ariani, Rizka Dewi, Fitria Puspita Muhammad Farid Putri, Ratna Aprillia Eka Rahma, Adinda Aulia Ramadhania, Widya Aryana Rizkita, Leonny Dwi Yuska, Shaldhan Bayu