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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Abdimas Kesehatan
Marisanti, Debi Putri
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Computer Science & IT Health Professions Medicine & Pharmacology Nursing Public Health

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Teh Celup Daun Pepaya (Carica papaya) Solusi Alami Antihipertensi di Dusun Tanah Abang, Desa Mersam Trifah, Rahmadha; Marisanti, Debi Putri; Siti Nurul Khoiriyah; Bella Melyani; Prima, Nurmalinda; Hutagalung, Bertha Uli; Ningsih, Ayi Setiya; Verra Veriska, Pretty Sepvanny; Devianti, Dina Nazifa; David Usmany, Abdillah
Jurnal Abdimas Kesehatan (JAK) Vol. 7 No. 2 (2025): Juni
Publisher : Universitas Baiturrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36565/jak.v7i2.916

Abstract

A community service activity with the theme "Papaya Leaf Tea Bags as Antihypertensive" has been carried out in Tanah Abang Hamlet, Mersam Village, Jambi Province, on January 12, 2025. This program aims to increase public knowledge about hypertension and the use of papaya leaves as an alternative to traditional medicine. The methods used include counseling, demonstrations, discussions, and questions and answers. The material presented included the definition of hypertension, causes, prevention, and how to process papaya leaves into tea bags. The results of the activity show the high enthusiasm of the community in understanding and practicing the making of papaya leaf tea bags. This program has succeeded in increasing public awareness of the importance of controlling hypertension through the use of natural ingredients, which is indicated by a significant increase in public knowledge of 80% after the activity was implemented. It is hoped that this activity can have a positive impact on hypertension control and public health in Mersam Village in a sustainable manner.
Ekstraksi Hijau Daun Senduduk (Melastoma malabathricum) Menggunakan NaDES: Formulasi Toner dan Evaluasi Antioksidan Putra, Rizky Yulion; Mariska, Ruri Putri; Permatasari, Jelly; Marisanti, Debi Putri; Meliani, Meliani
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 2 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i2.66702

Abstract

Daun senduduk (Melastoma malabathricum) mengandung senyawa bioaktif, salah satunya berperan sebagai antioksidan, tetapi pemanfaatannya sebagai kosmetik, khususnya toner, masih terbatas. Tingginya paparan radikal bebas menuntut hadirnya kosmetik alami, sehingga penggunaan pelarut ramah lingkungan seperti NaDES (Natural Deep Eutectic Solvent) menjadi solusi tepat. Penelitian ini bertujuan untuk mengarakterisasi sediaan toner ekstrak daun senduduk dengan NaDES (kolin klorida : asam laktat, 1:1) melalui metode sonikasi pada suhu 30°C dan 70°C selama 15 menit. Ekstrak diformulasikan menjadi enam variasi konsentrasi toner. Evaluasi meliputi uji organoleptik, homogenitas, pH, viskositas, stabilitas, iritasi, hedonik, serta karakterisasi partikel. Karakterisasi kimia dilakukan dengan LC-MS/MS serta uji antioksidan menggunakan metode DPPH dan FRAP. Hasil menunjukkan seluruh formula stabil dan memenuhi standar sediaan kosmetik. Uji iritasi menyatakan semua formula aman, dengan formula mengandung ekstrak NaDES 1% banyak disukai berdasarkan uji hedonik. Nilai IC50 terbaik diperoleh pada formula 5%, menunjukkan aktivitas antioksidan kuat sebesar 88,47 µg/mL (DPPH, 30°C) dan 95,50 µg/mL (FRAP, 70°C). Analisis LC-MS/MS formula 5% (30°C) mengidentifikasi senyawa terpenoid dan alkaloid. Pada uji partikel formula 5% (70°C) dengan ukuran partikel 35,6 nm dan nilai zeta potensial +161,1 mV.  Secara keseluruhan, toner ekstrak NaDES daun senduduk berpotensi dikembangkan sebagai kosmetik alami dengan aktivitas antioksidan kuat.
Co-Authors Bella Melyani David Usmany, Abdillah Devianti, Dina Nazifa Hutagalung, Bertha Uli Jelly Permatasari Meliani, Meliani Ningsih, Ayi Setiya Prima, Nurmalinda Putra, Rizky Yulion Rahmadha Trifah Ruri Putri Mariska Siti Nurul Khoiriyah Verra Veriska, Pretty Sepvanny