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All Journal International Journal of Health, Engineering and Technology
Rahmadha Trifah
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Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Dentistry Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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Effect of Bungur Leaf Extract on Glucose Reduction in Kidney Dysfunction Rats Nabhaki, Firelza; Indri Meirista; Rahmadha Trifah
International Journal of Health Engineering and Technology Vol. 4 No. 5 (2026): IJHESS JANUARY 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i5.513

Abstract

Diabetes mellitus is a metabolic disorder with an increasing prevalence in Indonesia, including in the city of Jambi. Conventional antidiabetic therapies such as metformin, sulfonylureas, and insulin are effective in lowering glucose levels, but long-term use can cause side effects, including the risk of kidney damage. Bungur leaves (Lagerstroemia speciosa) contain flavonoids, alkaloids, tannins, triterpenoids, and corosolic acid, which have potential antihyperglycemic and nephroprotective properties. This study aimed to evaluate the effects of bungur leaf ethanol extract on blood glucose levels and kidney function in male white rats induced with alloxan and gentamicin. The study was conducted experimentally with seven treatment groups. The parameters observed included blood glucose and serum creatinine levels. The results showed a significant decrease in glucose, with the highest effectiveness at a dose of 1200 mg/kgBW. The extract also lowered creatinine levels, indicating a renal protective effect. These findings suggest the potential of crape myrtle leaves as a herbal antidiabetic agent while maintaining renal function
The Effect Of Ethanol Extract From Tuba Leaves (Derris Elliptica) On The Decrease In Blood Glucose Levels In Male White Mice Mukhlis Sanuddin; Rahmadha Trifah; Siti Nurul Khoiriyah
International Journal of Health Engineering and Technology Vol. 4 No. 5 (2026): IJHESS JANUARY 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i5.514

Abstract

Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia, caused by disturbances in insulin secretion, insulin action, or both. One alternative treatment option is herbal/traditional medicine made from natural ingredients. This study aimed to determine the effect of ethanol extract of Tuba plant leaves (Derris elliptica) on blood glucose levels in male white mice induced with alloxan. This study used an experimental method in which mice were induced with diabetes using a dose of 150 mg/kgBW alloxan for 3 days. The test animals were divided into 6 treatment groups, each consisting of five mice. Group I, the normal control, was given 0.5% Na CMC; group II, the negative control, was given alloxan and 0.5% Na CMC; group III, the positive control, was given alloxan and glibenclamide; while groups IV, V, and VI were given alloxan and tuba leaf ethanol extract at doses of 100 mg/kgBW, 200 mg/kgBW, and 400 mg/kgBW, respectively. Blood glucose levels were measured on days 1, 7, 14, and 21. The results showed that a 400 mg/kg body weight dose of tuba leaf ethanol extract significantly reduced blood glucose levels by 125.4 mg/dl and was almost as effective as glibenclamide. A dose of 400 mg/kg body weight was the optimal dose, producing significant effects while remaining safe for use.
Co-Authors Indri Meirista Nabhaki, Firelza Sanuddin, Mukhlis Siti Nurul Khoiriyah