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Recurrent flaccid paralysis due to hypokalemia as an unusual presentation of hypothyroidism Nainggolan, Prima Heptayana; Meliala, Terang
Jurnal Prima Medika Sains Vol. 7 No. 1 (2025): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v7i1.5741

Abstract

Background: Recurrent flaccid paralysis with low level of potassium can be found in hypokalemic periodic paralysis or thyrotoxic periodic paralysis. Hypokalemic Periodic paralysis associated with hypothyroidism is rare in the existing literature. Case illustration: A 41-year-old man had been admitted to the emergency ward due to weakness of his lower extremities for 3 days before the admission. He had the same symptoms one year ago. Based on the physical examination, decreases in both muscle strength and physiological reflexes in lower extremities had been found. From laboratory examination, the serum potassium level had reduced up to 1,7 mmol/l, with high TSHs and normal T3 and T4 level. The nerve conduction studies had revealed normal limits. Following a potassium correction, the patient had shown improvement. Discussion: In most cases, hypokalemic periodic paralysis is caused by pure hypokalemia or high thyroid hormone level in serum (as in thyrotoxic periodic paralysis). However, this patient was diagnosed as hypokalemic periodic paralysis with subclinical hypothyroidism. This case is therefore a very rare and unusual presentation of hypothyroidism. The relation between hypokalemic periodic paralysis and hypothyroidism remains unclear. Conclusion: Hypokalemic periodic paralysis associated with hypothyroidism is rare and understanding about this condition has not been established thus far in the literature. Thyroid examination is needed for patients with hypokalemic periodic paralysis.
UJI PERBANDINGAN EKSTRAK DAUN SIRIH HIJAU (Piper betle l.) DAN CEFADROXIL TERHADAP KADAR HEMOGLOBIN PADA TIKUS WISTAR YANG TERINFEKSI Staphylococcus aureus Sihombing, Jenny Ria; Meliala, Terang; Naibaho, Tracy Angelique P
Kieraha Medical Journal Vol 7, No 1 (2025): KIERAHA MEDICAL JOURNAL
Publisher : Fakultas Kedokteran, Universitas Khairun

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33387/kmj.v7i1.9214

Abstract

Penelitian ini bertujuan untuk membandingkan pengaruh pemberian ekstrak daun sirih hijau (Piper betle L.) dan cefadroxil terhadap kadar hemoglobin pada tikus Rattus norvegicus yang terinfeksi Staphylococcus aureus. Penelitian ini melibatkan lima kelompok perlakuan, yaitu kontrol negatif, kontrol positif, dan tiga dosis ekstrak daun sirih hijau (300 mg/KgBB, 500 mg/KgBB, dan 1000 mg/KgBB). Kadar hemoglobin diukur menggunakan automatic hematology analyzer pada akhir penelitian. Hasil penelitian menunjukkan bahwa pemberian cefadroxil dapat meningkatkan kadar hemoglobin secara signifikan, sedangkan pemberian ekstrak daun sirih hijau dengan dosis yang berbeda tidak memberikan efek yang signifikan terhadap kadar hemoglobin. Meskipun demikian, ekstrak daun sirih hijau menunjukkan aktivitas antibakteri yang kuat terhadap Staphylococcus aureus. Dapat disimpulkan bahwa ekstrak daun sirih hijau, meskipun tidak meningkatkan kadar hemoglobin, memiliki potensi sebagai agen antibakteri.