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All Journal Medula Journal Medical Informatics Technology
Setyadi, Yudha Putra
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Computer Science & IT Dentistry Education Engineering Medicine & Pharmacology Neuroscience Public Health

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The role of Salmon DNA in Skin Regeneration and Anti-Aging Camilia, Anita; AP, Gadila; Dwiputri, Maliya Finda; Arief, Skolastika Faustina Ivana; Setyadi, Yudha Putra
Journal Medical Informatics Technology Volume 3 No. 2, June 2025
Publisher : SAFE-Network

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37034/medinftech.v3i2.95

Abstract

Salmon DNA, particularly its polydeoxyribonucleotide (PDRN) content, has attracted attention in dermatology due to its potential in skin regeneration and anti-aging applications. This review aims to summarize various research findings on the effectiveness of PDRN. The study was conducted through a literature review of articles published between 2016 and 2023. Findings indicate that PDRN works by activating adenosine A2a receptors, stimulating angiogenesis, cell proliferation, and reducing inflammation. Its combination with vitamin C and niacinamide enhances antioxidant effects and helps preserve the extracellular matrix. Furthermore, the use of long-chain polynucleotide fillers has been shown to significantly improve pore size, skin texture, wrinkles, and sagging, with minimal side effects. In conclusion, PDRN from salmon DNA is a promising bioactive agent for skin rejuvenation, wound healing, and anti-aging therapy in modern dermatological practice.
Review Article: Antibacterial Activity of Mangrove Lindur Extract (Bruguiera gymnorrhiza) Against Staphylococcus aureus Setyadi, Yudha Putra; Kurniawaty, Evi; Kusumaningtyas, Intan
Medula Vol 14 No 8 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i8.1300

Abstract

Infectious diseases remain prevalent in Indonesia, influenced by environmental factors such as poor sanitation, low public awareness of clean and healthy living behaviors, and a tropical climate. Infectious diseases are health issues caused by microorganisms, such as bacteria, viruses, or parasites, that enter the body. Staphylococcus aureus is one of the primary pathogens for humans and can cause various infections. The main treatment for Staphylococcus aureus infections is antibiotics. However, bacterial resistance to methicillin antibiotics (Methicillin-Resistant Staphylococcus aureus or MRSA) is increasingly common in Indonesia. Therefore, alternative antibiotic treatments based on plant-derived compounds are highly needed. One plant with potential antibacterial activity is Bruguiera gymnorrhiza. Commonly known as bakau lindur, various parts of Bruguiera gymnorrhiza, such as its bark, leaves, and roots, have antibacterial properties. This is attributed to the bioactive compounds present in its extracts, including flavonoids, saponins, alkaloids, phenols, steroids, terpenoids, and tannins.. This article aims to determine whether Bruguiera gymnorrhiza extract exhibits antibacterial activity against Staphylococcus aureus. Based on the literature review, Bruguiera gymnorrhiza extract has been proven to possess antibacterial activity against Staphylococcus aureus. The best antibacterial activity was observed in the 96% ethanol extract of Bruguiera gymnorrhiza bark at a concentration of 15,000 ppm, resulting in a 13.62 mm inhibition zone categorized as strong.
Co-Authors AP, Gadila Arief, Skolastika Faustina Ivana Camilia, Anita Dwiputri, Maliya Finda Intan Kusumaningtyas Kurniawaty, Evi