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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Medula Jurnal Dunia Kesmas Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) JURNAL PENELITIAN PERAWAT PROFESIONAL Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences JK Unila (Jurnal Kedokteran Universitas Lampung) Prosiding Konferensi Nasional PKM-CSR Jurnal Farmasetis Bagimu Negeri : Jurnal Pengabdian Kepada Masyarakat
Kurniawaty, Evi
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Antibacterial Screening of Mangrove Extract Library Showed Potential Activity against Escherichia coli and Staphylococcus aureus Audah, Kholis Abdurachim; Batubara, Razethy; Julkipli, Julkipli; Wijaya, Elza; Kurniawaty, Evi; Batubara, Irmanida
Journal of Tropical Life Science Vol 10, No 2 (2020)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.10.02.03

Abstract

Humans are at a continuous battle against different types of diseases, so that extraordinary effort to accelerate drug discovery has become a necessity. Indonesian biodiversity is abundant natural resources that can be utilized as potential drug sources. Mangroves are among potential plant medicines that grow nearly at all Indonesian coastlines. The aim of this study was to evaluate the potential of mangrove extracts (extract library) as antibacterial agents. In this study, eight mangroves species with 16 samples from different parts of the plants such as leaf, bark or root were collected. Four types of solvents with different polarity, namely water, ethanol, ethyl acetate and hexane were used in maceration of samples producing 64 extracts. Disk diffusion method was used for antibacterial screening using five bacterial strains. There were 37 extracts showed antibacterial potential with the lowest and the highest inhibition indexes were 0.0283 and 1.8983, respectively. The highest inhibition index was recorded for ethyl acetate extract of Bruguiera gymnorrhiza root (BgR (Ea)) against Escherichia coli. The second highest inhibition index was 0.7867 recorded water extract of Avicennia marina leaf (AmL (A)) against Staphylococcus aureus. Almost all of extract showed saponin and tannin in considerable amount. This supported the data that mangrove extracts were potential as antibacterial agents.
Hubungan Derajat Infeksi Soil Transmitted Helmints (STH) terhadap Peningkatan Jumlah Eosinofil pada Siswa SD Negeri di Kecamatan Jati Agung Kabupaten Lampung Selatan Mutiara, Hanna; Kurniawaty, Evi; Din, Bahesty Cut Nyak
Jurnal Kedokteran Universitas Lampung Vol 3, No 1 (2019): JK Unila
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jk unila.v3i1.2212

Abstract

Prevalensi infeksi Soil Transmitted Helminths (STH) di Indonesia masih menunjukkan angka yang tinggi pada siswa sekolah dasar (SD). Prevalensi usia tertinggi infeksi STH merupakan usia 6-12 tahun dimana kondisi ini dapat mempengaruhi intake, digestive, absorpsion, dan metabolisme makanan seseorang yang terinfeksi. Infeksi STH juga dapat menyebabkan peningkatan jumlah eosinofil sebagai suatu respon tubuh dalam melawan infeksi STH. Penelitian ini bertujuan untuk mengetahui hubungan derajat infeksi STH dengan peningkatan jumlah eosinofil pada siswa SD Negeri di kecamatan Jati Agung kabupaten Lampung Selatan. Penelitian ini menggunakan metode observasional analitik dengan pendekatan cross sectional. Sampel pada penelitian ini berjumlah 67 siswa SD Negeri di Kecamatan Jati Agung yang memenuhi kriteria inklusi. Pengambilan sampel dilakukan dengan cara total sampling dan data dianalisis menggunakan uji Kruskal Walis. Infeksi STH sebanyak 56,71% dengan 26,9% infeksi ringan dan 29,8% infeksi sedang. Peningkatan jumlah eosinofil dalam darah pada siswa yang tidak terinfeksi didapatkan nilai rata-rata 16,12; pada siswa yang terinfeksi ringan 40,53; pada siswa yang terinfeksi sedang 54,05. Terdapat hubungan infeksi STH terhadap peningkatan jumlah eosinofil pada siswa SD Negeri di Kecamatan Jati Agung secara statistik (nilai p=0.00). Kata kunci: derajat infeksi, infeksi STH, jumlah eosinofil, siswa
HUBUNGAN LAMA DEMAM DENGAN MANIFESTASI PERDARAHAN DAN KEBOCORAN PLASMA PASIEN ANAK PENDERITA INFEKSI DENGUE DI RSUD DR. H. ABDUL MOELOEK BANDAR LAMPUNG Alvinasyrah, Alvinasyrah; Apriliana, Ety; Kurniawaty, Evi
Jurnal Ilmu Kedokteran dan Kesehatan Vol 11, No 3 (2024): Volume 11 Nomor 3
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v11i3.13481

Abstract

Abstrak: Hubungan Lama Demam dengan Manifestasi Perdarahan dan Kebocoran Plasma Pasien Anak Penderita Infeksi Dengue di RSUD Dr. H. Abdul Moeloek Bandar Lampung. Infeksi dengue merupakan penyakit yang disebabkan oleh virus dengue dengan vektor pembawa Aedes aegypti L. dan Aedes albopictus. Infeksi dengue ditandai dengan demam tinggi, manifestasi perdarahan, dan kebocoran plasma. Manifestasi perdarahan terdiri dari petekie, epistaksis, perdarahan gusi dan gastrointestinal; kebocoran plasma terdiri dari peningkatan hematokrit ≥20%, efusi pleura, asites, dan hipoalbuminemia. Tujuan penelitian ini, untuk mengetahui hubungan lama demam dengan manifestasi perdarahan dan kebocoran plasma pasien anak penderita infeksi dengue di RSUD Dr. H. Abdul Moeloek Bandar Lampung. Jenis penelitian ini adalah penelitian observasional dengan desain penelitian potong lintang. Data diambil dari catatan rekam medik pasien infeksi dengue (≤18 tahun) selama tahun 2018-2019 di RSUD Dr. H. Abdul Moeloek Bandar Lampung. Analisis data dilakukan menggunakan uji Chi square dan Fisher’s exact. Hasil penelitian menunjukkan 50,5% berusia 6-12 tahun, 50,5% pada perempuan, 48,5% terdiagnosis DBD II, 27,3% demam hari 4 dan 6. 58,6% mengalami petekie dan 47,5% mengalami peningkatan hematokrit. Hasil uji Fisher’s exact dan Chi square menunjukkan nilai p= 0,232 pada manifestasi perdarahan dan nilai p= 0,139 pada kebocoran plasma. Kesimpulannya tidak terdapat hubungan antara lama demam dengan manifestasi perdarahan dan kebocoran plasma pasien anak penderita infeksi dengue di RSUD Dr. H. Abdul Moeloek Bandar Lampung.  
PEMERIKSAAN GOLONGAN DARAH DAN RHESUS PADA MASYARAKAT DESA SENDANG MULYO KECAMATAN SENDANG AGUNG KABUPATEN LAMPUNG TENGAH Andriani, Silvia; Puspa, Egita Windrianatama; Sahroni, Mizan; Arif, Muhammad; Sandro, Mario; Putra, Yogi Catur; Kurniawaty, Evi; Khairani, Iffa Afiqa
Bagimu Negeri Vol 7, No 2 (2023)
Publisher : Universitas Muhammadiyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52657/bagimunegeri.v7i2.2181

Abstract

Darah merupakan salah satu komponen paling penting yang ada dalam tubuh, mengingat fungsinya sebagai alat transportasi. Pemeriksaan golongan darah adalah salah satu aspek dalam upaya pencegahan penyakit. Identifikasi golongan darah dengan melihat penggumpalan darah yang telah diberi reagen banyak dilakukan secara manual berdasarkan pengamatan visual secara langsung. Pemeriksaan golongan darah dapat menjadi informasi penting dalam konteks perawatan kesehatan, terutama dalam situasi darurat atau ketika transfusi darah diperlukan. Indonesia masih mengalami kekurangan jumlah penyediaan darah secara nasional sebanyak 500 ribu kantong. Kekurangan ketersediaan darah tersebut meliputi golongan darah langka seperti golongan darah AB dan rhesus negatif. Pengabdian masyarakat adalah suatu kegiatan yang bertujuan untuk membantu masyarakat dalam meningkatkan pengetahuan dan derajat kesehatan. Kegiatan pengabdian masyarakat menjadi salah satu bagian dari Catur Dharma Perguruan Tinggi. Tujuan kegiatan pengabdian masyarakat ini adalah untuk mengetahui hasil pemeriksaan golongan darah dan rhesus pada masyarakat di desa Sendang Mulyo Kecamatan Sendang Agung. Desain kegiatan ini menggunakan desain deskriptif observational yaitu menggambarkan hasil pemeriksaan golongan darah berdasarkan hasil observasi dilapangan. Pemeriksaan Golongan darah sistem ABO yang dilakukan di Desa Sendang Mulyo diperoleh hasil golongan darah A sebanyak 9 orang, golongan darah B sebanyak 18  orang, golongan darah O sebanyak 24 orang, sedangkan untuk golongan darah AB sebanyak 4 orang
PERBEDAAN PENGARUH PEMBERIAN TOPIKAL EKSTRAK DAUN BAKAU (Bruguiera gymnorrhiza) DAN GEL BIOPLACENTON PADA MAKROSKOPIS KULIT TIKUS PUTIH JANTAN (Rattus norvegicus) GALUR Sprague dawley DENGAN LUKA SAYAT Akib, Salsabila Nadhifa; Kurniawaty, Evi
Medula Vol 13 No 7 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i7.886

Abstract

Wound is loss of continuity from tissue’s anatomical structure which can be caused by pathological process from within or outside body. Wound healing process consists of four stages, namely haemostasis, inflammation, proliferation, and maturation. Bruguiera gymnorrhiza mangrove plant is a type of mangrove that is rich in bioactive compounds. Bruguiera gymnorrhiza leaf extract has bioactive compounds that can work as antibacterial, anti-inflammatory, analgesic and proliferative agents which affect wound healing process. This research is pure experimental with post test only control group design. Sample consisted of 30 rats divided into 3 groups. K-: 0,2 cc topical aquades, K +: 0,2 cc topical bioplacenton gel, P1: Bruguiera gymnorrhiza leaf extract 80% in 14 days of observation. Observation data were recorded in observation sheet and analyzed statistically. The results showed that topical extract of Bruguiera gymnorrhiza leaves 80% affected macroscopic wound healing in form of wound length’s reduction to 0.17 cm on 14th day but Kruskal-wallis test showed no significant macroscopic difference in wound healing (p > 0.05) between K-, K +, and P1. Topical extract of Bruguiera gymnorrhiza leaves 80% affected macroscopic wound healing in form of wound length’s reduction but there was no significant difference in incision wound healing macroscopically between K-, K +, and P1 at dose 0.2 cc / day.
Mekanisme Kerja & Penggunaan Klinis N-Acetylcystein (NAC) Pada Penyakit Paru & Saluran Napas Poty, Pitha Maykania; Mustofa, Syazili; Kurniawaty, Evi; Soleha, Tri Umiana
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.1083

Abstract

Lung disease is one of the leading causes of illness and death worldwide. Lung disease can be caused by inflammation of the tissues due to oxidative stress. Oxidative stress plays a role in the pathogenesis of lung disease, both acute and chronic. Oxidative stress in the lungs occurs when antioxidant capacity is depleted due to external exposures, such as changes in oxygen pressure due to pollutants, and internal exposures, such as systemic disease and activation of inflammatory cells in response to exposure. Oxidative stress is an imbalance in the production of oxidants and antioxidants in the body's metabolism. In lung disease, oxidative stress increases in endogenous metabolism so exogenous antioxidants in the form of N-acetylcysteine ​​(NAC) are needed. NAC is a glutathione precursor that can replenish total thiols (cysteine, cysteinylglycine, glutathione, and homocysteine). The mechanism of action of NAC is by interacting with ROS so that it can increase antioxidant capacity again. Oxidative stress can deplete antioxidants, NAC will release Thiol groups directly thereby neutralizing oxidants such as N and NO2. Clinically, NAC has been proven to be useful as a treatment for lung diseases such as COVID-19, asthma, bronchiectasis, COPD, and TB at high doses, namely 1200 mg/day.
Pengaruh Pemberian Minyak Jelantah 1,5 mL/Hari Selama 14 Hari Terhadap Histopatologi Hepar Rattus norvegicus Jantan Ersa, Rakhmigasti Citra; Susianti, Susianti; Kurniawaty, Evi; Mustofa, Syazili
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.1088

Abstract

Using cooking oil multiple times can caused bad effect on health one of them is liver damage. Free radical content in reused cooking oil trigger oxidative stress then disturb the cellular respons in liver. This study aimed to determine the effect of giving reused cooking oil for 14 days on rats (Rattus norvegicus) liver histopathology. This study was a true experimental using 10 rats (Rattus norvegicus) and were devided by 2 groups, which are normal group (KN) and treatment group (KP) that was given 1,5 mL reused cooking oil per day. After 14 days of treatment, rats were terminated and the liver were taken. To observe rats liver histopathology, cloudy swelling scoring were used on 5 field of view. Score 0: there was no cloudy swelling and necrosis found, score 1: there was 1-20% cloudy swelling and necrosis found, score 2: there was 21-50% cloudy swelling and necrosis found, score 3: there was 51-75% cloudy swelling and necrosis found, and score 4: there was more than 75% cloudy swelling and necrosis found.It was found a minimal cloudy swelling on KN with average liver damage score was 0,04. In group KP it were found cloudy swelling degeneration on all over the liver with average liver damage score was 4. Mann-Whitney test showed a significant difference between groups. Giving reused cooking oil 1,5 ml/day for 14 days caused damage on male rats liver histopathology.
Variable Effect Analysis of Household Characteristics, Family Aware of Nutrition (Kadarzi) and Environmental Sanitation as Risk Factors for Stunting Events (Comparative Study of Agricultural and Non-Agricultural Family in the Regency of South Lampung Regency, 2022) Berawi, Khairunisa; Pramudyawati, Yustika; Kurniawaty, Evi; Bakri, Samsul; Zuraida, Reni
Budapest International Research and Critics Institute-Journal (BIRCI-Journal) Vol 5, No 4 (2022): Budapest International Research and Critics Institute November
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birci.v5i4.7125

Abstract

This study aims to analyze the effect of household characteristics, Kadarzi and environmental sanitation as risk factors for stunting in a comparative study of agricultural and non-agricultural families in South Lampung district. This study uses primary data obtained from questionnaires, that are data of family characteristics, Kadarzi and environmental sanitation from 198 household samples and secondary data, that are data of stunting toddlers and agricultural and non-agricultural areas in South Lampung district in 2022. To achieve the purpose of research, the research method used is observational analytic with a cross sectional approach. The research was conducted from July 2022 to September 2022. The results showed that on the household characteristics variable, variables that had a significant effect were family occupation and family income, while variables that had no significant effect were parents’ education, nutritional knowledge, and gender of children. On the Kadarzi variable, variables that had a significant effect were the behavioral variables of Kadarzi and exclusive breastfeeding, while variables that had no significant effect were variables of weight measurement, various foods, iodized salt and nutritional supplements. On the environmental sanitation variable, the variables that have a significant effect are family latrines, sewerage and agricultural and non-agricultural zones, while variables that have no significant effect are variables of clean water sources and trash bins.
Size Shortening of Body Parts of Fetus Mice (Mus musculus L.) After Giving Bitter Melon Fruit Extract (Momordica charantia L.) Andriani, Silvia; Nurcahyani, Nuning; Busman, Hendri; Sutyarso; Kurniawaty, Evi; Sahroni, Mizan; Puspa, Egita Windrianatama
Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) Vol. 10 No. 2 (2023)
Publisher : Department of Biology Faculty of Mathematics and Natural Sciences Universitas Lampung in collaboration with The Indonesian Association of Biology (PBI) Lampung Branch.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jbekh.v10i2.298

Abstract

Bitter melon (Momordica charantia L.) is a plant that has traditional medicinal properties. In bitter melon fruit, there are several toxic compounds, namely momordicoside K and L, which are thought to have cytotoxic properties. This study aims to determine the teratogenic effect of bitter melon fruit extract given to pregnant females on the length of the fetus' cranium and sternum. Bitter melon fruit extraction was carried out using the maceration method using 95% ethanol. By using a completely randomized design 20 male mice and 20 female mice were divided into 4 groups. Each group consisting of 5 pregnant female mice was given bitter melon extract orally starting from day 6 to day 17 of pregnancy once a day in the morning with a treatment dose of aquabidest as a control [A], [B] 22.5 mg/30 gr BW, [C] 30 mg/30 gr BW, and [D] 37.5 mg/30 gr BW. Next, the female mice were dissected, the fetus was removed and the length of the cranium and the length of the sternum were measured. The results showed that in general, the administration of bitter melon fruit extract caused a decrease in the average length of the cranium and sternum. The results of the further analysis with the Least Significant Difference (LSD) at the 5% level showed that administering doses of [B], [C], and [D] had a significant effect on reducing the length of the cranium and sternum. The most effective dose to reduce the length of the cranium and sternum of fetal mice is 37.5 mg/30 g BW
Uji Efektivitas Ekstrak Kulit Batang Bakau Lindur (Bruigiera gymnorrhiza) Sebagai Antibakteri Terhadap Streptococcus pyogenes Annisa Fath; Kurniawaty, Evi; Graharti, Risti; Berawi, Khairun Nisa
Medula Vol 14 No 8 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i8.1250

Abstract

The bacterium Streptococcus pyogenes is a gram-positive bacterium that causes various diseases in humans. Pharyngitis is the most common infection caused by Streptococcus pyogenes, occurring in 15-30% of children and 5-10% of adults. The extract of mangrove bark contains bioactive compounds that can serve as an antibacterial alternative.  This research is an experimental study. The mangrove bark was extracted using 96% ethanol solvent through the maceration method and subjected to phytochemical testing. The treatment consists of 96% ethanol extract preparations with concentrations of 25%; 50%; 70%; 90%; and 100%, as well as a negative control using aquades and a positive control using amoxicillin. Each treatment was repeated 4 times. Antibacterial activity testing was conducted using the well method on Muller Hinton Agar. The results of the phytochemical test showed that the 96% ethanol extract positively contained flavonoid, phenol, alkaloid, tannin, saponin, steroid, and triterpenoid compounds. The results of the antibacterial activity study from 25%, 50%, 70%, 90%, and 100% concentrations of 96% ethanol extract produced zone diameters of 4.33 mm; 5.68 mm; 6.61 mm; 7.72 mm; and 9.02 mm. These results indicate that the 96% ethanol extract of the mangrove bark has an inhibitory effect on the growth of Streptococcus pyogenes. Data analysis of the 96% ethanol extract of the mangrove bark using the One-Way ANOVA test showed p< 0.05.
Co-Authors Akib, Salsabila Nadhifa Alvinasyrah, Alvinasyrah Andriani, Silvia Annisa Fath Audah, Kholis Abdurachim Balqis, Aurelia Corrinna Batubara, Razethy Berawi, Khairunisa Dewi Nur Fiana Din, Bahesty Cut Nyak Dwi Indria Anggraini Elidiya, Anggun Ersa, Rakhmigasti Citra Ety Apriliana Hanna Mutiara, Hanna Hendri Busman Iffa Afiqa Khairani Irmanida Batubara Julkipli Julkipli, Julkipli Justiani, Andinni Aurellia Khairun Nisa Kurniati, Intanti Mallarangeng, Andi Nafisah Tendri Adjeng Muhammad Arif Muhammad Maulana Muhammad Ricky Ramadhian Nuning Nurcahyani Nurul Islamy Poty, Pitha Maykania Pramudyawati, Yustika Puspa, Egita Windrianatama Putra, Yogi Catur Rahmansia, Soraya Rahmayani, Fidha Reni Zuraida Risti Graharti Sahroni, Mizan Samsul Bakri Sandro, Mario Situmorang, Ephraim Matthew Sebastian Situmorang, Ezra Winandi Susianti Susianti Sutyarso Sutyarso Sutyarso Syazili Mustofa Tri Umiana Soleha Wijaya, Elza