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Azzahra, Andi
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Studi Farmakodinamik Infusa Daun Mimba dan Daun Nangka sebagai Kandidat Antipiretik Alami pada Tikus putih galur Wistar Haryanto; Astuti, Sri; Azzahra, Andi; Damayanti, Arfina; Aulia, Besse; Nurdiake, Besse; Ahmad, Najwa; Zulkifli; Putri, Ulfa
Health & Medical Sciences Vol. 2 No. 4 (2025): August
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/phms.v2i4.453

Abstract

Demam merupakan kondisi yang umum diatasi dengan sediaan antipiretik, namun penggunaan obat sintetik secara berlebihan dapat menimbulkan resistens, serta gangguan fungsi hati, sehingga diperlukan alternatif dari bahan alami. Penelitian ini bertujuan untuk mengevaluasi dan membandingkan efek antipiretik dari berbagai sediaan obat baik sintetik maupun herbal terhadap tikus putih (Rattus norvegicus) yang telah diinduksi demam. Penelitian dilakukan di Laboratorium Farmakologi dan Toksikologi FKIK Universitas Muhammadiyah Makassar. Induksi demam dilakukan menggunakan larutan pepton 5% secara intraperitoneal, kemudian hewan uji diberikan perlakuan berupa paracetamol, ibuprofen, natrium diklofenak, ekstrak daun nangka, ekstrak daun mimba, serta Na-CMC sebagai kontrol negatif. Suhu tubuh diukur melalui rektal secara berkala setiap 30 menit selama 2,5 jam. Data dianalisis menggunakan perangkat lunak SPSS melalui uji normalitas dan homogenitas. Hasil menunjukkan bahwa ibuprofen, paracetamol, infusa daun nangka, dan daun mimba secara berurutan memberikan penurunan suhu yang cukup signifikan dibandingkan sediaan lain, natrium diklofenak menunjukkan efektivitas yang lebih rendah. Na-CMC sebagai kontrol tidak memberikan efek antipiretik yang berarti. Namun demikian, hasil analisis statistik menunjukkan bahwa terdapat perbedaan efek yang signifikan antar kelompok perlakuan (nilai signifikansi < 0,05). Sedangkan uji lanjutan menunjukkan hasil yang nonsignifikan antara perlakuan obat ibuprofen, paracetamol, infusa daun nangka dan daun mimba yang berarti bahwa kedua sediaan infusa memiliki efek antipiretik.
EFEKTIVITAS PEMBELAJARAN INFORMATIKA BERBASIS PRAKTIK DALAM PENGENALAN SISTEM KOMPUTER PADA SISWA KELAS IX DI SMPN 1 GALESONG SELATAN Nurhidayani; Azzahra, Andi; Ardiana; Nasir
Pendas : Jurnal Ilmiah Pendidikan Dasar Vol. 11 No. 01 (2026): Volume 11 No. 01 Maret 2026 Published
Publisher : Program Studi Pendidikan Guru Sekolah Dasar FKIP Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/jp.v11i01.40503

Abstract

The development of information and communication technology (ICT) in the digital era requires educational institutions to equip students with digital literacy from an early age. One subject that plays a strategic role in developing these competencies is Informatics. However, Informatics learning at the junior high school level still tends to be theoretical and lacks direct practical activities, resulting in suboptimal student understanding of computer systems. This study aims to examine the effectiveness of practice-based Informatics learning on the learning outcomes of Grade IX students at SMPN 1 Galesong Selatan, as well as to describe student activities and responses to the implementation of this learning method. The study employed a quantitative approach using a pre-experimental design (One Group Pretest–Posttest Design) involving 23 students as research subjects. The results showed that the average pretest score of 76.25 increased to 87.91 in the posttest. A paired-sample t-test revealed that the calculated t-value (4.23) was greater than the t-table value (2.00), indicating a significant improvement in learning outcomes after the implementation of practice-based learning. Furthermore, 92% of students responded positively, suggesting that this method enhanced student engagement, motivation, and understanding of introductory computer systems material. Therefore, practice-based Informatics learning has proven effective in improving student learning outcomes.
Co-Authors Ahmad, Najwa Ardiana Aulia, Besse Damayanti, Arfina HARYANTO Nasir Nurdiake, Besse Nurhidayani Putri, Ulfa Sri Astuti Zulkifli