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All Journal Sasambo Journal of Pharmacy
Razkianita, Haulya
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Health Professions Medicine & Pharmacology

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Review artikel: validasi metode analisis kadar parasetamol dalam sediaan obat menggunakan berbagai instrumen Zanuba, Anisa; Permatasari, Lina; Febrianingsih, Karlina Dwi; Anindiya, Naya Wahyu; Razkianita, Haulya; Mustika, Mitha Juliana
Sasambo Journal of Pharmacy Vol. 6 No. 1 (2025): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v6i1.502

Abstract

Paracetamol is one of the analgesic-antipyretic drugs that has been widely used by the public as a first-line treatment. The level of paracetamol in each preparation must comply with the standards set in the Indonesian Pharmacopoeia so that it is necessary to determine the level. This study aims to evaluate the validation of the analysis method for paracetamol levels in various drug preparations using three main instruments: infrared spectrophotometry (FTIR), ultraviolet spectrophotometry (UV-Vis), and high-performance liquid chromatography (HPLC). Validation was carried out based on the parameters of accuracy, precision, limit of detection (LOD), and limit of quantification (LOQ). The results showed that the three instruments met the validation requirements set by the Indonesian Pharmacopoeia, with FTIR showing the best precision (RSD 0.03%), UV-Vis having the highest accuracy (% recovery 106.95%), and HPLC having the highest sensitivity with a LOD value of 0.76 µg/mL. For the levels of paracetamol with various dosage forms and instruments, the average results obtained meet the requirements, namely between 90%-110%. Overall, these methods are effective for the analysis of paracetamol levels, providing accurate and consistent results according to pharmacopoeial standards. Based on the review results, the instrument that mostly meets all the requirements for validation of the analysis method is HPLC.
Review artikel: analisis validasi metode penetapan kadar logam timbal (Pb) dalam kosmetik menggunakan berbagai instrumen Razkianita, Haulya; Permatasari, Lina
Sasambo Journal of Pharmacy Vol. 6 No. 2 (2025): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v6i2.589

Abstract

Lead (Pb) is one of the most commonly found heavy metal contaminants in cosmetic products. Continuous exposure to lead (Pb) can cause pathological changes in body organs and may lead to cancer. Therefore, it is essential to measure the concentration of lead in cosmetics to ensure safety and prevent potential side effects. This article aims to determine the most effective method for analyzing lead (Pb) content in cosmetic preparations using various instruments, including UV-Vis Spectrophotometry and Atomic Absorption Spectrophotometry (AAS). This study was conducted by comparing the validation results of both instruments. The results showed that the lead (Pb) content in most cosmetic preparations was below the safety limit set by the Badan Pengawas Obat dan Makanan (BPOM) Indonesian, which is <20 ppm. Atomic Absorption Spectrophotometry (AAS) was selected as the most optimal method, as it met all validation parameters with high accuracy and precision. It also demonstrated higher sensitivity, with lower LOD (Limit of Detection) and LOQ (Limit of Quantification) values compared to UV-Vis Spectrophotometry. Therefore, AAS is superior in detecting and quantifying lead in cosmetic preparations
Co-Authors Anindiya, Naya Wahyu Febrianingsih, Karlina Dwi Mustika, Mitha Juliana Permatasari, Lina Zanuba, Anisa