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All Journal Lumbung Farmasi : Jurnal Ilmu Kefarmasian Sasambo Journal of Pharmacy
Anindiya, Naya Wahyu
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Health Professions Medicine & Pharmacology

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Artikel Review : Potensi Ashitaba (Angelica keiskei) sebagai Alternatif Terapi di Bidang Dermatologi Anindiya, Naya Wahyu; Hidajat, Dedianto; Hidayati, Agriana Rosmalina
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 6, No 2 (2025): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v6i2.30595

Abstract

Ashitaba ( Angelica keiskei ) merupakan tanaman asal Jepang yang telah banyak dibudidayakan di Indonesia. Penelitian tentang ashitaba sudah banyak berkembang dalam bidang dermatologi sehingga tinjauan pustaka ini bertujuan untuk melihat perkembangan potensi ashitaba sebagai terapi alternatif di bidang dermatologi. Metode penelusuran artikel yang digunakan yaitu penelusuran artikel ilmiah melalui database seperti Google Scholar, ResearchGate dan Proquest dalam rentang waktu 2014-2024. Hasil tinjauan pustaka menunjukkan ashitaba berpotensi menjadi pengobatan alternatif dalam bidang dermatologi karena mengandung bioaktif yang memiliki aktivitas antibakteri, antiinflamasi, antioksidan, menghambat enzim tirosinase dan mengurangi ukuran tumor melanoma. Namun, penelitian lebih lanjut secara in vivo diperlukan untuk terapi jerawat vulgaris, serta uji klinis pada manusia untuk terapi penyembuhan luka, penuaan dini, hiperpigmentasi, dan melanoma.
Review artikel: validasi metode analisis kadar parasetamol dalam sediaan obat menggunakan berbagai instrumen Zanuba, Anisa; Permatasari, Lina; Febrianingsih, Karlina Dwi; Anindiya, Naya Wahyu; Razkianita, Haulya; Mustika, Mitha Juliana
Sasambo Journal of Pharmacy Vol. 6 No. 1 (2025): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v6i1.502

Abstract

Paracetamol is one of the analgesic-antipyretic drugs that has been widely used by the public as a first-line treatment. The level of paracetamol in each preparation must comply with the standards set in the Indonesian Pharmacopoeia so that it is necessary to determine the level. This study aims to evaluate the validation of the analysis method for paracetamol levels in various drug preparations using three main instruments: infrared spectrophotometry (FTIR), ultraviolet spectrophotometry (UV-Vis), and high-performance liquid chromatography (HPLC). Validation was carried out based on the parameters of accuracy, precision, limit of detection (LOD), and limit of quantification (LOQ). The results showed that the three instruments met the validation requirements set by the Indonesian Pharmacopoeia, with FTIR showing the best precision (RSD 0.03%), UV-Vis having the highest accuracy (% recovery 106.95%), and HPLC having the highest sensitivity with a LOD value of 0.76 µg/mL. For the levels of paracetamol with various dosage forms and instruments, the average results obtained meet the requirements, namely between 90%-110%. Overall, these methods are effective for the analysis of paracetamol levels, providing accurate and consistent results according to pharmacopoeial standards. Based on the review results, the instrument that mostly meets all the requirements for validation of the analysis method is HPLC.
Co-Authors Dedianto Hidajat Febrianingsih, Karlina Dwi Hidayati, Agriana Rosmalina Mustika, Mitha Juliana Permatasari, Lina Razkianita, Haulya Zanuba, Anisa