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All Journal Jurnal Kesehatan Tambusai Sasambo Journal of Pharmacy
Febrianingsih, Karlina Dwi
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Review artikel: validasi metode analisis kadar parasetamol dalam sediaan obat menggunakan berbagai instrumen Zanuba, Anisa; Permatasari, Lina; Febrianingsih, Karlina Dwi; Anindiya, Naya Wahyu; Razkianita, Haulya; Mustika, Mitha Juliana
Sasambo Journal of Pharmacy Vol. 6 No. 1 (2025): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v6i1.502

Abstract

Paracetamol is one of the analgesic-antipyretic drugs that has been widely used by the public as a first-line treatment. The level of paracetamol in each preparation must comply with the standards set in the Indonesian Pharmacopoeia so that it is necessary to determine the level. This study aims to evaluate the validation of the analysis method for paracetamol levels in various drug preparations using three main instruments: infrared spectrophotometry (FTIR), ultraviolet spectrophotometry (UV-Vis), and high-performance liquid chromatography (HPLC). Validation was carried out based on the parameters of accuracy, precision, limit of detection (LOD), and limit of quantification (LOQ). The results showed that the three instruments met the validation requirements set by the Indonesian Pharmacopoeia, with FTIR showing the best precision (RSD 0.03%), UV-Vis having the highest accuracy (% recovery 106.95%), and HPLC having the highest sensitivity with a LOD value of 0.76 µg/mL. For the levels of paracetamol with various dosage forms and instruments, the average results obtained meet the requirements, namely between 90%-110%. Overall, these methods are effective for the analysis of paracetamol levels, providing accurate and consistent results according to pharmacopoeial standards. Based on the review results, the instrument that mostly meets all the requirements for validation of the analysis method is HPLC.
LITERATURE REVIEW : PEMANFAATAN MINYAK ZAITUN (OLEA EUROPAEA) SEBAGAI EMOLIEN Fitriani, Risma; Febrianingsih, Karlina Dwi; Wandila, Welsi; Putrii, Dewi Angelita; Febriyanti, Syahrani; Almira, Nisrina Dea; Subaidah, Windah Anugrah
Jurnal Kesehatan Tambusai Vol. 7 No. 1 (2026): MARET 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v7i1.55522

Abstract

Kulit kering (xerosis) merupakan kondisi kulit ketika mengalami penurunan kelembaban stratum korneum. Salah satu upaya untuk mengatasi kondisi tersebut adalah penggunaan emolien. Minyak zaitun (Olea europaea) merupakan salah satu tanaman yang berpotensi sebagai emolien. Minyak zaitun mengandung asam lemak, seperti asam oleat, linoleat, dan palmitat, serta vitamin A, D, dan E, yang berperan penting dalam menjaga kelembaban kulit, melindungi dari radikal bebas, dan mengurangi inflamasi. Oleh karena itu, artikel ini bertujuan untuk mengevaluasi efektivitas minyak zaitun sebagai emolien melalui studi literatur yang diperoleh dari berbagai sumber, seperti PubMed dan Google Scholar. Hasil kajian menunjukkan bahwa minyak zaitun berfungsi sebagai emolien dalam berbagai bentuk sediaan, baik sebagai minyak topikal maupun kosmetik dengan sifat non-iritan, mampu meningkatkan hidrasi kulit, dan memperbaiki integritas kulit. 
Co-Authors Almira, Nisrina Dea Anindiya, Naya Wahyu Febriyanti, Syahrani Fitriani, Risma Mustika, Mitha Juliana Permatasari, Lina Putrii, Dewi Angelita Razkianita, Haulya Wandila, Welsi Windah Anugrah Subaidah Zanuba, Anisa