Article Per Year (5 Year)
p-Index From 2020 - 2025
0.444
P-Index
This Author published in this journals
All Journal Pharmacy Reports Jurnal Pendidikan Bahasa dan Sastra Indonesia
Cahyani, Nabila
Unknown Affiliation
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Molecular docking of piperine, limonene, and eugenol in black pepper (Piper nigrum L.) as anti-stroke Azzahra, Fauzia; Nadapdap, Ezra Gabriella Oktaviany; Cahyani, Nabila; Salsabila, Fathul Aini; Afada, M. Mufti; Auli, Winni Nur; Saputro, Anjar Hermadi
Pharmacy Reports Vol. 4 No. 3 (2024): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.79

Abstract

Stroke remains a leading cause of death and disability worldwide, necessitating the development of effective therapeutic agents. This study explores the potential of bioactive compounds from Piper nigrum L. (black pepper) as anti-stroke candidates targeting the cGMP-specific phosphodiesterase 5A (PDE5A) receptor (PDB ID: 3BJC). The evaluation employed molecular docking and drug-likeness assessment methodologies. Piperine, limonene, and eugenol were assessed using Lipinski's Rule of Five (RO5) to predict oral bioavailability. All compounds met the RO5 criteria, indicating favorable drug-likeness characteristics. Molecular docking was validated through re-docking of the native ligand WAN, yielding an RMSD ≤ 2 Å, confirming the accuracy of the docking protocol. Following validation, molecular docking analysis revealed that piperine demonstrated the lowest binding energy (-7.71 kcal/mol), followed by limonene (-5.28 kcal/mol) and eugenol (-4.86 kcal/mol). Visualization results revealed that piperine shared key interaction motifs and amino acid residues with the native ligand, including hydrogen bonding and hydrophobic interactions, indicating strong receptor affinity and molecular stability. Additionally, the ligand-receptor interaction distance of piperine (2.21 Å) closely resembled the native ligand (2.15 Å), further supporting its structural and functional similarity. These findings highlighted piperine as the most promising anti-stroke candidate among the tested compounds. Further in vitro and in vivo studies are recommended to validate its pharmacological efficacy and safety.
Pembentukan Etika dan Nilai Melalui Integrasi Epistemologi, Metafisika, dan Aksiologi Panggabean, Rosalina; Zahara, Listia; Cahyani, Nabila
Jurnal Pendidikan Bahasa dan Sastra Indonesia Vol. 1 No. 1 (2025): January
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/jpbsi.v1i1.1365

Abstract

Tujuan mini riset mengidentifikasi integrasi antara epistemologi, metafisika,dan aksiologi pada pendidikan, mengeksplorasi penerapan integrasi ketiga aspek ini untuk menciptakan etika dan nilai, menemukan Solusi terhadap tantangan penerapan integrasi ini pada pendidikan baru. Metode penelitian ini bersifat kualitatif, data dalam penelitian ini akan dianalisis melalui metode kuesioner yang disebarluaskan dari  hasil penelitian dan diagram sebelumnya mengungkapkan bagaimana pembentukan seseorang memahami pentingnya etika dan nilai melalui integrasi diera modern.  
Co-Authors Afada, M. Mufti Anjar Hermadi Saputro Fauzia Azzahra, Fauzia Nadapdap, Ezra Gabriella Oktaviany Panggabean, Rosalina Salsabila, Fathul Aini Winni Nur Auli Zahara, Listia