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All Journal Jurnal Biomedika dan Kesehatan Medicosphere
Napitupulu, Partogi
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences

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Gambaran Schizencephaly dengan Polymicrogyria pada Berbagai Magnetic Resonance Imaging (MRI) Sekuens Tanaji, Tandy; Hendara, Farah; Marliana, Caecilia; Astien, Astien; Nareswari, Gupita; Napitupulu, Partogi; Rahmansyah, Mulia; Wahab, Revalita
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.73-78

Abstract

Schizencephaly is a rare congenital cerebral malformation within the category of neurological migration defects. Hemiparesis, developmental delays, and seizures are clinical signs that are influenced by both the size and the location of the lesion. This condition is characterized by a cleft that traverses the brain's parenchyma lined by grey-mater (transmantle cleft). In less severe cases, the cleft does not extend into the lateral ventricle. Identification of the cleft's path, accurate assessment of the cortex, and recognition of polymicrogyria are crucial for the radiological evaluation of schizencephaly. We report a case of 18-year-old male diagnosed with closed-lip schizencephaly, which supported by MRI findings. The transmantle cleft and polymicrogyria are most effectively visualized in T2-weighted and FLAIR images. The utility of diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) sequences as well as susceptibility-weighted imaging (SWI) sequence in the context of schizencephaly currently remains uncertain, however it may be useful for ruling out other abnormalities such infarct, hemorrhagic, tumors or other vascular abnormalities. In this context, we emphasize the significance of MRI examination for diagnosing this condition and for recognizing the related abnormalities.
Natural History of Subarachnoid Hemorrhage - A Case Report in Developing Country: A Case Report Makkiyah, Feda Anisah; Ayu Devania Dipta Gayatri, Gusti; Napitupulu, Partogi
Journal of Diverse Medical Research: Medicosphere Vol. 2 No. 7 (2025): J Divers Med Res 2025
Publisher : Faculty of Medical - UPN Veteran Jawa Timur

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Abstract

Stroke is the second leading cause of death and a significant factor in global disability. Its incidence is highest in developing nations, with ischemic strokes being the most prevalent. Only about 10% to 15% of first-time strokes are Intracerebral Hemorrhages (ICH). Primary hemorrhages make up the majority of strokes, while secondary hemorrhages account for roughly 10–25%. Hydrocephalus is a common complication of aneurysmal subarachnoid hemorrhage (aSAH). Additionally, the presence of hydrocephalus can indicate a greater likelihood of poor outcomes following an ICH. This case explains the natural history of subarachnoid and its management outside of developing countries. VP shunts are often used to treat post-hemorrhagic hydrocephalus, as was done in this case. Rebleeding after VP shunt placement is common. Therefore, appropriate management is needed to prevent increased mortality. Although proper management requires high costs in developing countries.
Co-Authors Astien, Astien Ayu Devania Dipta Gayatri, Gusti Caecilia Marliana, Caecilia Hendara, Farah Makkiyah, Feda Anisah Nareswari, Gupita Rahmansyah, Mulia Tanaji, Tandy Wahab, Revalita