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All Journal Sari Pediatri Jurnal Bidan Pintar (JuBiTar) JURNAL INOVASI DAN PENGABDIAN MASYARAKAT INDONESIA Mandala of Health : A Scientific Journal
Marfu’ati, Nanik
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Humanities Dentistry Education Health Professions Nursing Public Health Social Sciences

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EFEK PROPOLIS SEBAGAI RENOPROTEKTOR TERHADAP GAMBARAN HISTOPATOLOGI GINJAL MENCIT YANG DIINDUKSI PARASETAMOL Baihaqi, Achmad Alfan; AD, Noor Yazid; Marfu’ati, Nanik
Mandala Of Health Vol 17 No 2 (2024): Mandala of Health: a Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.2.9607

Abstract

The use of paracetamol with a toxic dose of 15 grams/day can cause damage, one of which is the kidney in the form of acute tubular necrosis. Propolis has a renoprotector effect through an antioxidant mechanism. The purpose of this study is to identify the renoprotector effect of propolis on the histopathological appearance of paracetamol-induced mouse kidneys. This research was an experimental research using the Post Test Only Control Group Design method. The sample of this study were 28 Swiss Webster mice divided into 4 groups: group (K-) was not given propolis and paracetamol, group (K+) was given paracetamol at a dose of 250 mg/kg BW; group (P1) was given propolis at a dose of 0.100 ml and group (P2) 0.125 ml was then induced by paracetamol at a dose of 250 mg/kgBW. The research was conducted for 10 days. Data were analyzed using the One Way Anova and Post Hoc LSD tests to determine whether there were significant differences in the histopathological appearance of the kidneys between treatment groups. The One Way Anova test showed significant differences in all treatment groups with p<0.05. The results of the LSD Post Hoc test showed that there was a significant difference between the K- group and the K + group, between the K + group and the P1 and P2 groups there was a significant difference. There was no significant difference between group P1 and group P2. There was an effect of propolis renoprotector on the histopathological appearance of paracetamol-induced mouse kidneys. Giving propolis at a dose of 0.100 ml was more optimal in preventing kidney damage in mice than a dose of 0.125 ml.
THE THE EFFECT OF HEPATOPROCTECTIVE PROPOLIS ON THE HISTOPATHOLOGY OF THE LIVER CELL MICE INDUCED BY PARACETAMOL Salsabila, Shofa; Yazid, Noor; Marfu’ati, Nanik
Mandala Of Health Vol 18 No 2 (2025): Mandala of Health: A Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2025.18.2.17250

Abstract

The overdose of paracetamol utility may increase N-acetyl-p-benzoqui-noneimine (NAPQI) and produce the free radicals, which will cause liver cell damage. Propolis contains antioxidants which have the ability to capture free radicals The aim of this study is to identify the hepatoprotective effect of propolis doses of 0.4 ml and 0.8 ml on the histopathological appearance of the liver of mice induced by paracetamol. This research was an experimental research using the Post Test Only Control Group Design method. The sample of this study were 24 Swiss Webster mice divided into 4 groups: group (K-) not given propolis and paracetamol; group (K+) was given paracetamol at a dose of 338 mg/kgBB; group (P1) was given a dose of 0.4 ml of propolis and group (P2) 0.8 ml and then induced by paracetamol at a dose of 338 mg/kgBB. This research was conducted for 14 days and on the 15th day termination was carried out to observe the histopathological picture of the liver tissue. There was a statistically significant hepatoprotective effect of propolis in the histopathological picture of the liver in the K- group under normal circumstances (score 1), the K+ group was dominated by necrosis (score 4), the P1 group was dominated by normal cells (score 1) and the P2 group was dominated by hydropic degeneration (score 3). The Kruskal-Wallis test showed a significant difference in all treatment groups with p<0.001. The results of the Mann-Whitney test showed that between the K– group and the K+ group and the P2 group there was a significant difference, between the K+ group and the P1 and P2 groups there was a significant difference, and between the P1 group and the P2 group there was a significant difference with p<0,05. There was a hepatoprotective effect of propolis on the histopathological of the liver of mice induced paracetamol. Propolis dose of 0.4ml was more optimal in preventing damage to the liver of mice than a dose of 0.8ml.
Pendidikan, Pekerjaan, dan Pola Asuh Orang Tua terhadap Perkembangan Motorik Kasar dan Personal Sosial Anak Autis Faroch, Indah Ainun; Ramaningrum, Galuh; Marfu’ati, Nanik
Sari Pediatri Vol 26, No 1 (2024)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp26.1.2024.16-22

Abstract

Latar belakang. Gangguan perkembangan interaksi sosial dan motorik pada anak dengan autisme akan mengganggu pada aktivitas sehari-hari, hubungan interpersonal, dan kehidupan di masa dewasa. Terdapat aspek yang memengaruhi perkembangan anak yang dibagi menjadi dua faktor, yaitu genetik dan lingkungan. Faktor lingkungan meliputi pola asuh dan karakteristik keluarga.Tujuan. Mengetahui hubungan pendidikan, pekerjaan, pola asuh orang tua terhadap perkembangan motorik kasar dan personal sosial anak dengan autis.Metode. Penelitian dengan metode potong lintang pada anak diagnosa autisme yang tergabung di Terapi Taman Bintang dan Sekolah Inklusi Kristha Pertiwi beserta ibu periode Maret-April 2023 dengan total sampling. Analisis bivariat menggunakan uji chi-square dan multivariat dengan regresi logistic.Hasil. Berdasarkan analisis bivariat pendidikan (p=0,355) dan pekerjaan (p=0,399) orang tua tidak berhubungan terhadap perkembangan motorik kasar. Pendidikan (p=0,336) dan pekerjaan (p=0,247) orang tua juga tidak berhubungan terhadap perkembangan personal sosial. Pola asuh orang tua berhubungan terhadap motorik kasar (p=0,042) dan personal sosial (p=0,017) anak autisme. Hasil analisis multivariat pola asuh merupakan faktor yang paling signifikan terhadap mototik kasar anak autisme (p=0,026; OR;16,371 IK95% 1,51-177,24).Kesimpulan. Pola pengasuhan orang tua berpengaruh signifikan terhadap motorik kasar dan personal sosial anak autisme. Sementara tidak terdapat hubungan antara pekerjaan dan pendidikan orang tua terhadap motorik kasar dan personal sosial anak autis.
A COMPARISON OF NEUTROPHIL LYMPHOCYTE RATIO (NLR) BEFORE AND AFTER ANTI TUBERCULOSIS TREATMENT BASED ON AGE AND SEX CHARACTERISTICS Azmi, Annisa Nurul; Hediningsih, Yekti; Marfu’ati, Nanik
Mandala Of Health Vol 16 No 2 (2023): Mandala of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2023.16.2.8181

Abstract

Indonesia is ranked third in the world with the most Tuberculosis (TB) cases. TB is an infection caused by bacteria thus can cause an inflammatory response then affects Neutrophil Lymphocyte Ratio (NLR). Anti-tuberculosis treatment with bactericidal and sterilization principles is expected to kill TB germs and reduce NLR values. The aim of this study was to analyze the NLR values in tuberculosis patients before and after anti-tuberculosis treatment based on age and sex characteristics. This is an analytic observational study using retrospective cohort approach in patients diagnosed with TB at the Muhammadiyah Kendal Hospital during January - August 2022. 70 samples were obtained through a purposive sampling method. This research used secondary data laboratory results consist of identity and NLR values before and after anti-tuberculosis treatment then analyzed with SPSS. Research data distribution wasn't normal. Results showed there was a significant comparison which was lower NLR values after treatment (p <0.001) and a significant conversion of NLR values from abnormal to normal (p <0.001). There was no significant difference based on sex before (p = 0.758) and after (p = 0.115) treatment. No significant difference was found by age category before (p = 0.174) and after (p = 0.284) treatment. Comparison of NLR values before and after anti-tuberculosis treatment found that there was a decrease in NLR values and most of the conversions were from abnormal to normal, but there were no differences based on age or sex characteristics.
Edukasi Pengetahuan Infeksi Jamur Superfisial dan Potensi Penggunaan Tanaman Obat sebagai Terapi Antijamur Ratnaningrum, Kanti; Rakhmawatie, Maya Dian; Marfu’ati, Nanik
JURNAL INOVASI DAN PENGABDIAN MASYARAKAT INDONESIA Vol 2 No 1 (2023): Januari
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jipmi.v2i1.69

Abstract

Latar belakang: Infeksi jamur superfisial masih menjadi masalah kesehatan di Indonesia. Indonesia merupakan daerah tropis dengan tingkat kelembaban tinggi. Hal ini merupakan kondisi yang baik untuk pertumbuhan jamur. Sebagian penderita infeksi jamur superfisialis masih memilih menggunakan obat yang dijual bebas tanpa resep dokter. Penggunaan obat tanpa resep dokter meningkatkan potensi resistensi obat. Indonesia memiliki variasi tumbuhan yang dapat digunakan sebagai alternatif pengobatan termasuk sebagai antijamur. Tujuan: Meningkatkan pengetahuan infeksi jamur superfisialis dan potensi tanaman obat yang digunakan sebagai terapi antijamur. Metode: Edukasi berbentuk kegiatan edukasi dengan materi infeksi jamur superfisial dan potensi penggunaan tanaman obat sebagai terapi antijamur. Kegiatan dilakukan di laboratorium Biomedik Fakultas Kedokteran Universitas Muhammadiyah Semarang menggunakan media power point. Evaluasi dilakukan menggunakan analisis kuantitatif hasil pre-test dan post-test. Hasil: Terdapat peningkatan signifikan pengetahuan peserta edukasi dengan rerata 24,6 poin (p=0,005). Kesimpulan: Terdapat peningkatan pengetahuan perihal infeksi jamur superfisial dan potensi penggunaan tanaman obat sebagai terapi antijamur. Kata Kunci: antijamur, dermatofitosis, infeksi jamur, tanaman obat ________________________________________________________________________________________ Abstract Background: Superficial fungal infection is still a health problem in Indonesia. Indonesia is a tropical area with high humidity levels. These are favorable conditions for fungal growth. Some people with superficial fungal infections still choose to use over-the-counter drugs without a doctor's prescription. The use of drugs without a doctor's prescription increases the potential for drug resistance. Indonesia has a variety of plants that can be used as traditional drugs, including antifungals. Objective: Increase knowledge of superficial fungal infections and the potency of medicinal plants used as antifungal therapy. Method: This activity is outreach with material on superficial fungal infections and the potential use of medicinal plants as antifungal therapy. The activity was carried out in the Biomedical Laboratory of the Faculty of Medicine Universitas Muhammadiyah Semarang using PowerPoint media. Result: There is a significant increase in the knowledge of participants, with an average increase of 24.6 points (p-value 0,005). Conclusion: There is an increase in knowledge about superficial fungal infections and the potential use of medicinal plants as antifungal therapy.   Keywords: antifungal, dermatophytosis, fungal infection, medicinal plant
KARAKTERISTIK PASIEN EPILEPSI Izzah, Vina Shofiyatul; Murwani Yekti; Marfu’ati, Nanik
Jurnal Bidan Pintar Vol. 6 No. 2 (2025): November 2025
Publisher : Universitas Kadiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30737/jubitar.v7i1.7077

Abstract

ABSTRAK   Epilepsi adalah penyakit kronik pada otak yang mempengaruhi sekitar lima puluh juta orang di dunia. Menurut Epilepsi Foundation tahun 2017, di dunia terdapat penderita epilepsi hingga 65 juta jiwa. Penelitian ini bertujuan untuk mengetahui karakteristik pasien epilepsi di RSUD Tugurejo Semarang Bulan Oktober 2021 – Oktober 2022. Penelitian ini bersifat kuantitatif, observasional deskriptif dengan pendekatan cross-sectional. Pengambilan data menggunakan data sekunder berupa rekam medis penderita epilepsi. Diperoleh data yang memenuhi kriteria inklusi sebesar 107. Data dianalisa menggunakan program komputer SPSS secara deskriptif. Sebagian besar pasien mengalami bangkitan pertama kali pada usia ≤ 5 tahun (25,2%). Sebagian besar pasien adalah laki-laki (56,1%). Jenis kejang yang sering dialami pasien adalah kejang umum (81,3%). Jenis terapi OAE yang sering diberikan adalah monoterapi (63,6%). Durasi konsumsi obat lebih banyak dilakukan selama ≤ 2 tahun (59,8%). Usia bangkitan pertama kali paling sering pada usia ≤5 tahun, sering terjadi pada jenis kelamin laki-laki, kejang yang sering terjadi adalah kejang umum, paling banyak menggunakan monoterapi, serta durasi konsumsi obat ≤ 2 tahun.    Kata Kunci    : epilepsi, karakterteristik, obat anti-epilepsi
Co-Authors AD, Noor Yazid Azmi, Annisa Nurul Baihaqi, Achmad Alfan Faroch, Indah Ainun Galuh Ramaningrum, Galuh Hediningsih, Yekti Izzah, Vina Shofiyatul Kanti Ratnaningrum Maya Dian Rakhmawatie Murwani Yekti Noor Yazid Salsabila, Shofa