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All Journal Pharmademica: Jurnal Kefarmasian dan Gizi Proceeding of International Conference Health, Science And Technology (ICOHETECH) Prosiding Seminar Informasi Kesehatan Nasional
Khusain, Muhammad Fuad Zidane
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Health Professions Industrial & Manufacturing Engineering Medicine & Pharmacology Nursing Public Health

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ANALISIS EFEKTIVITAS BIAYA TERAPI ANTIKOAGULAN PADA PASIEN STROKE ISKEMIK DENGAN ATRIAL FIBRILASI DI RUMAH SAKIT UMUM DAERAH (RSUD) Dr. MOEWARDI Khusain, Muhammad Fuad Zidane; Luthfiyanti, Niken; Wardani, Tatiana Siska
Prosiding Seminar Informasi Kesehatan Nasional 2025: SIKesNas 2025
Publisher : Fakultas Ilmu Kesehatan Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/nqca8689

Abstract

Stroke iskemik merupakan jenis stroke yang paling banyak terjadi dan seringkali disertai dengan komplikasi atrial fibrilasi, yang meningkatkan risiko stroke berulang. Penggunaan terapi antikoagulan menjadi tatalaksana penting, namun perlu dipertimbangkan tidak hanya dari segi efektivitas klinis tetapi juga efektivitas biayanya. Penelitian ini bertujuan untuk mengetahui efektivitas biaya terapi antikoagulan serta menilai cost-effectiveness berdasarkan perhitungan ACER. Penelitian ini merupakan penelitian observasional dengan pendekatan retrospektif dan metode analisis kuantitatif. Data diperoleh dari rekam medis pasien dan data pembayaran pasien selama dirawat di RSUD Dr. Moewardi Surakarta dalam periode 2025. Analisis data mencakup efektivitas terapi berdasarkan kejadian stroke berulang dengan parameter INR (International Normalized Ratio) dimana dikatakan bebas stroke berulang mendapat angka 2-3, serta analisis biaya medis langsung dari persepektif rumah sakit. Hasil penelitian menunjukkan bahwa warfarin merupakan antikoagulan yang paling sering digunakan (77,8%) dengan efektivitas 35%, lebih tinggi dari heparin (18%). Namun hasil uji Chi-Square menunjukkan nilai p= 0,112 (>0,05), yang berarti tidak terdapat perbedaan signifikan secara statistik antara efektivitas kedua terapi. Dari sisi biaya, warfari memiliki total biaya lebih rendah dibandingkan dengan heparin. Analisis ACER menunjukkan bahwa warfarin lebih cost-effective. Uji sensitivitas juga mendukung stabilitas hasil tersebut.
Hormonal Therapy Treatment Pattern For Breast Cancer Patients At Dr. Moewardi Hospital, Surakarta Luthfiyanti, Niken; Rohmana, Vivin Marwiyati; Khusain, Muhammad Fuad Zidane
Proceeding of the International Conference Health, Science And Technology (ICOHETECH) 2025: Proceeding of the 6th International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/bfz6xt62

Abstract

Breast cancer is a cancer with a high prevalence and mortality rate in women. One of the main therapies for hormone receptor-positive patients isAdjuvant Endocrine Therapy (AET) in the form of tamoxifen, either alone or in combination. The study aims to determine patient characteristics and patterns of hormonal therapy use.breast cancer patients at Dr. Moewardi Regional Hospital, Surakarta. The study used a randomized controlled study design.cross sectional with technique purposive samplingThe study subjects were 64 breast cancer patients undergoing tamoxifen therapy for at least one month. Data were obtained from medical records and questionnaires, then tested using Chi-Square see the relationship between variables. The results of the study showed that the majority of patients were aged <50 years (60.9%) and were in advanced stages (III–IV) at 57.8%. The most common type of therapy was a combination of chemotherapy and hormones (51.6%), while single hormonal therapy was used in 48.4% of patients. The most frequently used chemotherapy regimen was a combination of Cyclophosphamide & Epirubicin, while the most common hormonal therapy was Tamoxifen + Zoladex. Bivariate analysis showed a significant relationship between age and type of therapy and stage and type of therapy (p<0.05).
A Pola Pengobatan dan Efek Samping Terapi Hormonal pada Pasien Kanker Payudara di RSUD Dr. Moewardi Surakarta Luthfiyanti, Niken; Rohmana, Vivin Marwiyati; Khusain, Muhammad Fuad Zidane
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 5 No 2 (2026): Oktober - Maret
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v5i2.137

Abstract

Breast cancer is one of the most prevalent malignancies in women and remains a leading cause of cancer-related mortality. One of the main treatment modalities for hormone receptor–positive breast cancer is Adjuvant Endocrine Therapy (AET), particularly tamoxifen, either as monotherapy or in combination. This study aimed to evaluate patient characteristics, treatment patterns of hormonal and chemotherapy regimens, as well as adverse drug reactions (ADRs) among breast cancer patients at Dr. Moewardi General Hospital, Surakarta. This study employed a cross-sectional design with purposive sampling. A total of 64 breast cancer patients who had received tamoxifen therapy for at least one month were included. Data were collected from medical records and questionnaires, and analyzed using the Chi-Square test to determine associations between variables. The results showed that most patients were <50 years old (60.9%) and diagnosed at advanced stages (III–IV, 57.8%). The most frequent treatment was a combination of chemotherapy and hormonal therapy (51.6%), while hormonal therapy alone was administered in 48.4% of patients. The most commonly prescribed chemotherapy regimen was Cyclophosphamide & Epirubicin, whereas the most frequent hormonal regimen was Tamoxifen + Zoladex. Bivariate analysis indicated significant associations between age and treatment type, as well as between cancer stage and treatment type (p<0,05). However, no significant associations were found between age, stage, or type of therapy and ADRs (p>0.05). The most commonly reported adverse effects were fatigue, hot flushes, nausea, and bone/joint pain, with a small proportion reporting endometrial cancer.
Co-Authors Luthfiyanti, Niken Rohmana, Vivin Marwiyati Wardani, Tatiana Siska