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All Journal Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES)
Jihan Al Ihsani
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Health Professions Medicine & Pharmacology Nursing Public Health

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Studi Literatur : Analisis Efek Toksik pada Kasus Bunuh Diri Akibat Penggunaan Amfetamin Kanza Hanun Nafisah; Liska Virgiawari Aji Rabbani; Khaila Zaharani Riyanto; Ira Amelia Putri; Jihan Al Ihsani; Dwi Larasati Setyaningrum
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 4 No. 2 (2025): Agustus : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v4i2.5769

Abstract

This study aims to analyze the toxic effects brought about by amphetamine use and its association with suicides. Suicide is an act of ending one's own life that is often associated with mental health disorders and life pressures. Amphetamines are classified as Class II psychotropic drugs that have a strong stimulant effect on the central nervous system, causing changes in behavior and mental activity, including hallucinations, thought disorders, and emotional changes. This study was conducted based on a literature review, identifying and analyzing various suicide cases involving amphetamine use through relevant literature. The results of the literature analysis indicate that amphetamine use significantly increases the risk of suicidal behavior, which can affect neurotransmitters, potentially triggering psychosis, nerve damage, and cardiovascular issues. Chronic use leads to dependence, cognitive impairment.
Literature Review: Potensi Senyawa Bahan Alam sebagai Inhibitor HMG-CoA Reduktase untuk Terapi Kolesterol Khansa Aliifah; Hilma Marisa; Indah Lestari; Jelita Septiani; Jihan Al Ihsani; Muhamad Iqbal Rhamadianto
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 4 No. 2 (2025): Agustus : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v4i2.5991

Abstract

Hyperlipidemia is a condition in which lipid levels in the bloodstream (plasma) experience an imbalance in lipid levels, although it does not show severe symptoms but can trigger various serious diseases. Statins are used as the main therapy for antidyslipidemia, but with long-term use, statins cause various side effects such as muscle pain, muscle disorders and muscle discomfort. Indonesia has a variety of plants that have benefits for lowering blood cholesterol levels. To determine the potential of metabolite compounds contained in several plants as HMG-COA Reductase inhibitors, research can be carried out using molecular docking. The purpose of this literature study is to determine the comparison of compounds that have HMG-COA Reductase inhibitor inhibitor activity. The method used in compiling this literature study is from various national and international scientific articles published in the period 2020-2025. The natural compounds that have been studied have significant inhibitory activity against the HMG-CoA Reductase enzyme, namely from the 10 plants studied, Rhodomyrtus tomentosa has the best activity in inhibiting the HMG-CoA Reductase enzyme with an Affinity of the Binding value of -11.4 so that it has the potential to be further developed as a natural anti-cholesterol drug.
Co-Authors Dwi Larasati Setyaningrum Hilma Marisa Indah Lestari Ira Amelia Putri Jelita Septiani Kanza Hanun Nafisah Khaila Zaharani Riyanto Khansa Aliifah Liska Virgiawari Aji Rabbani Muhamad Iqbal Rhamadianto