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All Journal Acta Pharmaciae Indonesia : Acta Pharm Indo Greensphere: Journal of Environmental Chemistry
Cahyaningrum, Yanuar As'hari
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Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology

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Effectiveness analysis of single and combined antihypertensive in coronary heart disease patients at Madiun Hospital, East Java Cahyaningrum, Yanuar As'hari; Febriana, Laela; Putra, R.F.X. Premihadi
Acta Pharmaciae Indonesia Vol 12 No 2 (2024): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2024.12.2.13712

Abstract

Background: Coronary heart disease (CHD) patients frequently require antihypertensive therapy to achieve optimal blood pressure control and reduce cardiovascular complications. The comparative effectiveness of monotherapy versus combination antihypertensive regimens remains an important clinical consideration. Objective: To evaluate the effectiveness of monotherapy and combination antihypertensive treatments in achieving target blood pressure control among hospitalized CHD patients. Methods: This retrospective analysis examined medical records of 139 CHD patients hospitalized between April and June 2021 at a regional hospital in Madiun, East Java. Treatment effectiveness was defined as achieving blood pressure targets below 140/90 mmHg. Independent Sample T-tests compared treatment outcomes between groups. Results: Among 139 patients, 46 received monotherapy and 93 received combination therapy. Monotherapy effectiveness ranged from 80.0% to 88.8%, with calcium channel blockers achieving the highest success rate. Combination therapy demonstrated effectiveness rates between 76.9% and 91.8%, with angiotensin receptor blocker plus calcium channel blocker combinations showing optimal performance. Statistical analysis revealed significant differences in systolic blood pressure reduction between approaches (p=0.000), while diastolic outcomes showed no significant difference (p=0.632). Conclusion: Both treatment approaches demonstrate substantial effectiveness, with combination therapy providing particular advantages for systolic blood pressure management in coronary heart disease patients.
Kombucha Herbal Pegagan-Melinjo: Optimasi Formulasi, Metode Ekstraksi, dan Mekanisme Sinergis Antioksidan Kurniawati, Nurrizka; Cahyaningrum, Yanuar As'hari; Febriana, Laela; Kusuma, Ilham Budi; Mukharomah, Muhimmatul
Greensphere: Journal of Environmental Chemistry Vol 5, No 2 (2025): Volume 5 Nomor 2 Tahun 2025
Publisher : Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/gjec.2025.29573

Abstract

Penelitian ini bertujuan untuk mengoptimalkan formulasi kombucha herbal menggunakan daun pegagan (Centella asiatica L.) dan melinjo (Gnetum gnemon L.) serta mengevaluasi efek sinergisnya terhadap aktivitas antioksidan. Dua belas formulasi dikembangkan dengan variasi basis teh (teh hijau dan teh hitam), ekstraksi (infus dan maserasi), dan komposisi herbal (tunggal dan kombinasi). Proses fermentasi dilakukan selama 14 hari, dan aktivitas antioksidan diukur menggunakan metode DPPH. Hasilnya menunjukkan variasi aktivitas antioksidan yang signifikan di antara formulasi, dengan nilai IC50 berkisar antara 8,70 hingga 22,60 µg/mL. Kombinasi teh hijau dengan ekstrak daun pegagan dan melinjo (Formulasi FF) menunjukkan aktivitas antioksidan terkuat (IC50 8,70 µg/mL), yang 1,6 kali lebih kuat daripada asam askorbat (IC50 14,23 µg/mL) sebagai standar. Keempat formulasi teratas dengan aktivitas antioksidan tertinggi mengandung kombinasi kedua herbal tersebut menegaskan efek sinergis yang jernih. Metode maserasi secara konsisten menghasilkan aktivitas antioksidan yang lebih unggul dibandingkan dengan metode infus. Temuan ini menunjukkan bahwa formulasi kombucha herbal yang dioptimalkan memiliki potensi besar sebagai minuman fungsional berkadar antioksidan tinggi, dengan kombinasi pegagan dan daun melinjo yang menunjukkan peningkatan sinergis yang signifikan terhadap senyawa bioaktif. 
Co-Authors Febriana, Laela Kurniawati, Nurrizka Kusuma, Ilham Budi Mukharomah, Muhimmatul Putra, R.F.X. Premihadi