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All Journal Jurnal Ners al Kimiya : Jurnal Ilmu Kimia dan Terapan
Fajry, Zaidan Al
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Medicine & Pharmacology Nursing

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Biomass Contents Of Chlorella Pyrenoidosa Cultivated In Cobalt-Less Fertilizer-Enriched Saline Water Widyatama, Awang; Widyatama, Satria Aqilla; Fajry, Zaidan Al; Atmadi, Atmadi; Mulyawati, Ade Heri; Stiawan, Elva
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol. 12 No. 1 (2025): June 2025
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v12i1.39468

Abstract

This research aims to provide some information regarding the metabolite contents of the green microalgae Chlorella pyrenoidosa cultivated in designed saline water enriched with affordable commercial fertilizer products in Indonesia. Chlorella pyrenoidosa growth conditions and bioactive compounds were obtained through cultivation and extraction processes. The microalga growth in two different conditions   was analyzed based on growth curves between microalgae cultivated in a Guillard f/2 medium   and the Cobalt-less fertilizer-enriched saline water.   The biomass was profiled using UPLC-QToF-MS and DPPH assay. As a result, Chlorella pyrenoidosa cultures were normally grown on fertilizer-enriched saline water, but with a lower yield performance than those cultivated in the Guillard f/2 medium. The UPLC-QToF-MS result implies that several peptide and lipid derivatives were detected in the harvested microalgal biomass, with the peptide derivatives as the dominant compounds. The limited antioxidant performance was displayed by the untreated biomass extract. This finding implies that several optimizations are still required in the upstream and downstream stages in culturing Chlorella pyrenoidosa by using an uncommon growth medium.
Kajian Sistematis Potensi Interaksi Obat-Obat Herbal Terhadap Enzim Sitokrom P450 (Cyp450) Dan Implikasi Klinisnya pada Pasien Kanker yang Menjalani Kemoterapi Pamungkas, Bayu; Andriadi, Andhini Dwi; Fajry, Zaidan Al
Jurnal Ners Vol. 10 No. 1 (2026)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.51601

Abstract

Abstrak Latar belakang: Penggunaan obat herbal bersamaan dengan kemoterapi semakin meningkat di kalangan pasien kanker. Beberapa herbal diketahui memengaruhi aktivitas enzim sitokrom P450 (CYP450), yang berperan penting dalam metabolisme obat antikanker. Perubahan aktivitas enzim ini dapat menimbulkan interaksi farmakokinetik yang berdampak pada efektivitas maupun toksisitas terapi. Tujuan: Kajian sistematis ini bertujuan menilai potensi interaksi obat-herbal terhadap isoenzim CYP450 serta implikasi klinisnya pada pasien kanker. Metode: Penelusuran literatur dilakukan melalui ScienceDirect, MDPI, Frontiers, BMC, dan Nature dengan kata kunci “herbal-drug interaction”, “cytochrome P450”, dan “anticancer drugs”. Artikel yang disertakan mencakup studi in vitro, in vivo, observasional, dan laporan kasus yang meneliti efek herbal terhadap CYP1A2, CYP2C9, CYP2C19, CYP2D6, dan CYP3A4. Hasil: Sepuluh artikel memenuhi kriteria inklusi. Herbal seperti St. John’s wort, Ginkgo biloba, Panax ginseng, Curcuma longa, dan Allium sativum terbukti memengaruhi aktivitas CYP3A4 dan CYP2D6. Simpulan dan saran: Herbal dapat memodulasi aktivitas CYP450 sehingga memengaruhi efektivitas dan keamanan kemoterapi. Diperlukan skrining penggunaan herbal sebelum terapi serta penelitian klinis lanjutan untuk memperkuat bukti hubungan ini. Kata Kunci: interaksi obat-herbal, sitokrom P450, kemoterapi, pasien kanker, farmakokinetik.. Abstract Background: The concurrent use of herbal medicines and chemotherapy is increasingly common among cancer patients. Many herbs are known to affect cytochrome P450 (CYP450) enzyme activity, which plays a crucial role in the metabolism of anticancer drugs. Altered CYP450 activity may lead to pharmacokinetic interactions that impact drug efficacy and toxicity. Objective: This systematic review aims to evaluate the potential herb–drug interactions involving CYP450 isoenzymes and their clinical implications in cancer patients undergoing chemotherapy. Methods: Literature was retrieved from ScienceDirect, MDPI, Frontiers, BMC, and Nature using the keywords “herbal-drug interaction,” “cytochrome P450,” and “anticancer drugs.” Eligible studies included in vitro, in vivo, observational, and case reports investigating the effects of herbs on CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4. Results: Ten studies met the inclusion criteria. Herbs such as St. John’s wort, Ginkgo biloba, Panax ginseng, Curcuma longa, and Allium sativum were found to modulate CYP3A4 and CYP2D6 activity. Conclusion and recommendation: Herbal medicines can significantly alter CYP450-mediated drug metabolism, affecting chemotherapy safety and efficacy. Patient screening and further large-scale clinical trials are recommended. Keywords: herb–drug interaction, cytochrome P450, chemotherapy, cancer patients, pharmacokinetics
Efektivitas Terapi Metformin Terhadap Penurunan Skor Nafld pada Pasien Diabetes Melitus Tipe 2 dengan Hepatosteatosis Andriadi, Andhini Dwi; Pamungkas, Bayu; Fajry, Zaidan Al
Jurnal Ners Vol. 10 No. 1 (2026)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.51606

Abstract

Abstrak Latar belakang: Non-Alcoholic Fatty Liver Disease (NAFLD) merupakan komplikasi metabolik yang umum pada pasien diabetes melitus tipe 2 (DMT2), ditandai oleh akumulasi lemak hati akibat resistensi insulin yang dapat berkembang menjadi steatohepatitis dan fibrosis. Karena belum tersedia terapi farmakologis spesifik, metformin agen sensitisasi insulin golongan biguanid menjadi kandidat potensial untuk menurunkan aktivitas NAFLD melalui perbaikan metabolisme glukosa dan lipid. Tujuan: Menilai efektivitas metformin terhadap penurunan skor aktivitas NAFLD pada pasien DMT2 dengan hepatosteatosis. Metode: Kajian ini menggabungkan hasil uji klinis dan meta-analisis penggunaan metformin 1.500–2.000 mg/hari selama 6–12 bulan. Parameter yang dinilai mencakup kadar ALT, AST, HOMA-IR, trigliserida, serta perubahan NAFLD Activity Score (NAS) melalui temuan histologis atau MRI hati. Hasil: Metformin menurunkan kadar ALT/AST, meningkatkan sensitivitas insulin, dan menurunkan skor NAS rata-rata 2–3 poin. Mekanismenya melalui aktivasi AMPK, penurunan SREBP-1c dan ACC, serta peningkatan oksidasi asam lemak. Simpulan dan saran: Metformin efektif memperbaiki aktivitas NAFLD dan fungsi hati pada pasien DMT2; studi jangka panjang dibutuhkan untuk memastikan dampaknya terhadap fibrosis dan risiko hepatokarsinoma. Kata Kunci: Metformin; Diabetes Melitus Tipe 2; NAFLD; Hepatosteatosis. Abstract Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is a common metabolic complication in type 2 diabetes mellitus (T2DM), characterized by hepatic fat accumulation due to insulin resistance that may progress to steatohepatitis and fibrosis. Since no specific pharmacologic therapy exists, metformin—a biguanide insulin sensitizer emerges as a potential treatment due to its effects on hepatic glucose and lipid metabolism. Objective: To evaluate the efficacy of metformin in reducing NAFLD activity score among T2DM patients with hepatic steatosis. Methods: This review integrates clinical trials and meta-analyses assessing metformin 1,500–2,000 mg/day for 6–12 months. Parameters analyzed included ALT, AST, HOMA-IR, triglycerides, and changes in NAFLD Activity Score (NAS) based on histological or MRI findings. Results: Metformin significantly reduced ALT and AST levels, improved insulin sensitivity, and decreased NAS by an average of 2–3 points. The mechanism involves AMPK activation, downregulation of SREBP-1c and ACC, and enhanced hepatic fatty acid oxidation. Conclusion and recommendation: Metformin effectively improves NAFLD activity and liver function in T2DM patients; long-term studies are required to confirm its role in fibrosis prevention and hepatocarcinoma risk reduction. Keywords: Metformin; Type 2 Diabetes Mellitus; NAFLD; Hepatosteatosis.
Co-Authors Andriadi, Andhini Dwi Atmadi, Atmadi bayu pamungkas Elva Stiawan Mulyawati, Ade Heri Widyatama, Awang Widyatama, Satria Aqilla