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All Journal Journal of Agromedicine and Medical Sciences Universa Medicina Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) Vision Science and Eye Health Journal
Hibatulloh, Muhammad Farhan
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Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Other

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Systematic review and meta-analysis of antibiotic strategies for survival in patients with drug-resistant Acinetobacter baumannii infection: does quantity matter? De Rorna, Masrahma Reinataya; Ramadhani, Alfiyah; Hibatulloh, Muhammad Farhan; Agustina, Dini
Universa Medicina Vol. 44 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.232-244

Abstract

Background Acinetobacter baumannii is an opportunistic pathogen frequently associated with severe hospital-acquired infections, particularly in intensive care units, and is characterized by high levels of antibiotic resistance, including to carbapenems. The rising prevalence of multidrug- and pan-drug-resistant strains poses significant therapeutic challenges and underscores the need for optimized treatment strategies to improve survival outcomes. This systematic review and meta-analysis evaluates the impact of different antibiotic treatment modalities (monotherapy versus combination) on the clinical outcome of patients with Acinetobacter baumannii infection. Methods This systematic review and meta-analysis followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. To find pertinent studies released up to 3 January 2025 a thorough search was done in electronic databases such as PubMed, Embase, ScienceDirect, Cochrane, EBSCOhost, Google Scholar, and Scopus.  Results This systematic review and meta-analysis identified 20 studies for inclusion. No statistically significant overall survival difference was found (Pooled OR = 0.83, 95% CI [0.66- 1.03], p = 0.09), but subgroup analyses indicated that combination therapy markedly enhanced survival rates in patients with carbapenem-resistant Acinetobacter baumannii  (CRAB) infection, APACHE II scores below 20, and bloodstream infections. Meta-regression suggested that age may adversely affect treatment efficacy.   A trend favoring combination therapy was consistent across subgroups, despite some results not reaching statistical significance. Conclusion This systematic review and meta-analysis highlights the treatment challenges of drug-resistant Acinetobacter baumannii, particularly MDRAB, XDRAB, and CRAB strains. Combination therapy offers potential benefits in CRAB and moderate-severity cases but is not universally superior to monotherapy. Treatment outcomes are influenced by patient-specific factors such as age, infection type, and disease severity.
Computational Insights into Leucaena leucocephala Extract Shampoo as a Malassezia furfur Anti-Dandruff Agent Hibatulloh, Muhammad Farhan; Nafisa, Tsabita; Afnan, Muhammad Syifaul; Andriani, Made Prasanti; Widanto, Cika Abadi Laily; Wisudanti, Desie Dwi
Journal of Agromedicine and Medical Sciences Vol. 11 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i2.24051

Abstract

Dandruff is a scalp condition characterized by excessive flaking resulting from colonization by the fungus Malassezia furfur. Chemical-based anti-dandruff shampoos frequently result in side effects, including irritation, resistance, and hair discoloration. This study investigates the efficacy of Leucaena leucocephala leaf extract as a natural treatment for dandruff using an in-silico methodology. This research employed molecular modeling and docking assays targeting the 14-alpha lanosterol demethylase enzyme (CYP51), the primary antifungal target in Malassezia furfur. The docking results indicated that the active compounds in Leucaena leucocephala leaves, namely squalene and lupeol, exhibit a competitive binding affinity for CYP51, similar to the mechanism of action of ketoconazole. Squalene engages in polar interactions akin to the natural ligands of CYP51, whereas lupeol demonstrates robust hydrophobic interactions, suggesting its potential as an enzyme inhibitor. The findings indicate that herbal compounds derived from Leucaena leucocephala may serve as a natural alternative for dandruff treatment, presenting a reduced risk of side effects relative to synthetic chemicals. Further in vivo studies are necessary to validate the effectiveness and safety of anti-dandruff topical formulations. Keywords: CYP51, Dandruff, Leucaena leucocephala, Malassezia furfur, Natural antifungal
Expanding the role of mobile apps in preventing hyperphosphatemia in patients undergoing haemodialysis: A systematic review and meta-analysis Hibatulloh, Muhammad Farhan; Amini, Stefia Aisyah; Putri, Dhiani Eka; Rachmawati, Dwita Aryadina
Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) VOLUME 12 ISSUE 5, 2024
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/ijnd.2024.12(5).319-329

Abstract

Background: Improper diets of patients with chronic kidney disease undergoing hemodialysis are likely to develop hyperphosphatemia, which can also result in other complications such as lacking of calcium and protein. Meanwhile, dietary management using Mobile Apps can provide specific diet programs for every patient to control nutrition.Objectives: This review aims to identify the effectiveness of Mobile App based self-management dietary program to control phosphate, calcium, and albumin level for patients with hemodialysis.Methods: This systematic review and meta-analysis follows PRISMA (Preferred Reporting Items for Systematic and Meta-Analysis) Guideline. Study selection was done using several electronic databases such as PubMed, Cochrane Library, ScienceDirect, Springer, EBSCO, EMBASE, Google Scholar, Proquest, SAGE, Taylor & Francis, and SCOPUS. Bias risk was analyzed with Cochrane Risk of Bias 2.0 Tool, then meta-analysis was made using Review Manager V5.4.Results:This study included 5 randomized controlled studies that were later interpreted with meta-analysis. Based on the result, there are significant effect for phosphate level reduction (pooled MD -0.63, 95% CI [-1.18,-0.08], p=0.02, I2=82%) and calcium level increase (pooled MD=-0.51, 95% CI [-0.77,-0.24], p=0.0002, I2=0%). Meanwhile, there is no significant change in albumin level (pooled MD=-0.09, 95% CI [-0.33,0.16], p=0.49, I2=0%).Conclusions: In conclusion, mobile App based self-management diet significantly reduces phosphate level and is likely to maintain albumin level for hemodialysis patients. This intervention also has the potential to increase calcium levels to prevent bone disease.
Global Trends and Local Gaps: A Bibliometric Analysis and Case Series of Neonatal Conjunctivitis in Southeast Asia Nurhidayat, Bimanda Rizki; Hibatulloh, Muhammad Farhan; Irwanda, Thalita Permata P.; Farhah, Anitya Izdihar; Devi, Rossi Silvia
Vision Science and Eye Health Journal Vol. 5 No. 3 (2026): Vision Science and Eye Health Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/vsehj.v5i3.2026.97-103

Abstract

Introduction: Neonatal conjunctivitis, or ophthalmia neonatorum, is a preventable disease but is frequently neglected, especially in developing regions such as Southeast Asia, due to limited data availability and public awareness. This study aims to investigate global research trends in neonatal conjunctivitis through bibliometric mapping while concurrently presenting clinical patterns through a localized case series from Indonesia. Case Presentation: A comprehensive bibliometric analysis was conducted using RStudio on 468 articles from the Web of Science database. Simultaneously, two clinically validated cases of neonatal conjunctivitis were documented to exemplify local diagnostic and management challenges. The bibliometric analysis indicated a substantial escalation in global research activity on neonatal conjunctivitis over the preceding two decades; however, it also revealed a pronounced underrepresentation from low- and middle-income nations. The case series provided insight into typical presentations of Neisseria gonorrhoeae (N. gonorrhoeae)-associated and empirically treated conjunctivitis, underscoring issues such as delayed diagnosis, inadequate prior treatment, and the critical significance of appropriate antibiotic administration and follow-up care. Conclusion: The uneven distribution of research efforts in high-income nations, coupled with enduring clinical deficiencies in Southeast Asia, underscores the urgent need to develop regionally tailored public health strategies. Enhanced antenatal screening, education for healthcare providers, and the establishment of standardized neonatal prophylactic protocols are essential to mitigate the incidence and long-term repercussions of neonatal conjunctivitis.
Co-Authors Afnan, Muhammad Syifaul Amini, Stefia Aisyah Andriani, Made Prasanti De Rorna, Masrahma Reinataya Desie Dwi Wisudanti Devi, Rossi Silvia Dini Agustina Dwita Aryadina Rachmawati Farhah, Anitya Izdihar Irwanda, Thalita Permata P. Nafisa, Tsabita Nurhidayat, Bimanda Rizki Putri, Dhiani Eka Ramadhani, Alfiyah Widanto, Cika Abadi Laily