Wangidjaja, Olivia
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Probiotics for Preventing Relapse in Ulcerative Colitis: A Systematic Review and Bayesian Network Meta-Analysis Alvianto, Steven; Muzellina, Virly Nanda; Widjanarko, Nicolas Daniel; Lee, Yeong Yeh; Wangidjaja, Olivia
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 2 (2025): VOLUME 26, NUMBER 2, August, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2622025130-142

Abstract

Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by periods of relapse and remission. Preventing relapse is critical to improving long-term outcomes. This study aimed to compare the efficacy of probiotics, 5-aminosalicylic acid (5-ASA), probiotics combined with 5-ASA, and placebo in preventing relapse in UC.Methods: A comprehensive search from PubMed, Cochrane Library, MEDLINE, ProQuest, ScienceDirect, Clinical Trials. gov and Google Scholar databases were conducted. The primary outcome was clinical relapse. A Bayesian random-effects model calculated pooled odds ratios (ORs) with 95% CIs and treatment ranks were assessed using the surface under the cumulative ranking curve (SUCRA).Results: Of total 552 initial papers, 37 extracted, and 26 were removed due to exclusion criteria. Eleven RCTs involving 1,099 participants were eventually included for analysis. Probiotics combined with 5-ASA had the highest efficacy (OR = 0.23, 95% CI: 0.027–1.09; SUCRA = 71.43), followed by 5-ASA alone (OR = 0.25, 95% CI: 0.035–0.95; SUCRA = 66.90) and probiotics alone (OR = 0.275, 95% CI: 0.059–0.724; SUCRA = 59.69). Placebo ranked lowest (SUCRA = 1.98). The most commonly used probiotics included E. coli Nissle 1917, Lactobacillus GG, and Bifidobacterium species. The most frequently used 5-ASA preparation was mesalazine. Interventions were generally well-tolerated, with no significant adverse events reported. Conclusion: With the Bayesian NMA, Probiotics plus 5-ASA demonstrates the highest efficacy in preventing relapses in UC. Further research is needed to standardize probiotic regimens and to assess long-term outcomes with the combination approach.
Patient Satisfaction Among Noncommunicable Disease Patients in Klinik K Wangidjaja, Olivia; Tan, Jacob Donald
Indonesian of Health Information Management Journal (INOHIM) Vol 13, No 2 (2025): INOHIM
Publisher : Lembaga Penerbitan Universitas Esa Unggul

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47007/inohim.v13i2.659

Abstract

Abstract Noncommunicable diseases (NCDs) are a leading cause of global mortality, and patient satisfaction serves as a critical indicator of healthcare quality, especially in primary healthcare settings where long-term management is essential. This study aims to explore the level of patient satisfaction and identify key contributing factors among NCDs patients at Klinik K, a facility with a high volume of BPJS Kesehatan users and regular chronic care visits. The methodology includes semi-structured interviews with nine informants selected through purposive sampling, complemented by field notes and observations.The findings reveal that patients were positively satisfied when they received consistent health control, health education, and patient care center. However, patient satisfaction was negatively impacted by the lack of facility environment, service accessibility timing, medication stock availability, digital health accessibility, and diagnostic test availability These insights may facilitate better communication between patients and clinic management, leading to improvements in the delivery of NCDs care at Klinik K. Keyword: noncommunicable diseases; patient satisfaction; healthcare service; primary healthcare; case study Abstrak Penyakit Tidak Menular (PTM) merupakan penyebab utama kematian secara global, dan kepuasan pasien menjadi indikator penting dalam menilai kualitas layanan kesehatan, terutama di fasilitas layanan kesehatan primer yang berperan dalam pengelolaan jangka panjang. Penelitian ini bertujuan untuk mengeksplorasi tingkat kepuasan pasien serta mengidentifikasi faktor-faktor utama yang berkontribusi terhadap kepuasan pasien PTM di Klinik K, sebuah fasilitas yang melayani banyak pengguna BPJS Kesehatan dan kunjungan rutin untuk perawatan penyakit kronis. Metodologi penelitian mencakup wawancara semi-terstruktur terhadap sembilan informan yang dipilih melalui teknik purposive sampling, serta dilengkapi dengan catatan lapangan dan observasi. Hasil penelitian menunjukkan bahwa pasien merasa puas ketika mereka menerima pelayanan kontrol kesehatan, edukasi kesehatan, dan layanan yang berpusat pada pasien. Namun, kepuasan pasien menurun akibat kurangnya kenyamanan lingkungan fasilitas, keterbatasan waktu akses layanan, ketersediaan stok obat yang tidak memadai, aksesibilitas layanan digital yang rendah, serta keterbatasan dalam ketersediaan tes diagnostik. Temuan ini diharapkan dapat menjadi dasar untuk meningkatkan komunikasi antara pasien dan pihak manajemen klinik guna memperbaiki kualitas layanan kesehatan bagi pasien PTM di Klinik K. Kata Kunci: penyakit tidak menular; kepuasan pasien; pelayanan kesehatan; layanan kesehatan primer; studi kasus
Tinjauan atas Epilepsi Pasca-Trauma Kapitis Wangidjaja, Olivia; Wreksoatmodjo, Budi Riyanto
Cermin Dunia Kedokteran Vol 49 No 11 (2022): Neurologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i11.314

Abstract

Epilepsi pasca-trauma kapitis merupakan salah satu disabilitas akibat cedera kepala; yaitu bangkitan epileptik yang terjadi setelah 7 hari sampai bertahun-tahun pasca-trauma kapitis. Epilepsi pasca-trauma kapitis lebih sering ditemukan pada laki-laki, terutama di kelompok usia 0-12 tahun dan 15-27 tahun. Beberapa mekanisme perubahan aktivitas otak yang memicu bangkitan setelah cedera kepala, antara lain peningkatan penanda inflamasi dan sitokin serta perubahan sawar darah-otak; perubahan tersebut berperan penting dalam patogenesis kejang pasca-trauma. Pengobatan anti-konvulsan (OAE) jangka panjang direkomendasikan untuk pasien epilepsi pasca-trauma kapitis. Tingkat remisi epilepsi pasca-trauma kapitis adalah sekitar 25% - 40% dengan pengobatan awal yang dilakukan. Post-traumatic epilepsy, one of the disabilities due to head injury, is epileptic seizures that occur after 7 days to years after head injury. It is more common in males and peaks in the 0-12 year and 15-27 year age groups. Several mechanisms may trigger changes in brain activity after head injury; including increased inflammatory markers and cytokines, and changes in the blood-brain barrier; those changes may play an important role in the pathogenesis of posttraumatic seizures. Long-term anticonvulsant treatment (OAE) is recommended for patients with posttraumatic epilepsy. The remission rate of post-traumatic epilepsy is 25%-40% with early initial treatment.