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All Journal MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Jurnal Ilmu Kedokteran dan Kesehatan
Indrasari, Setyarina
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Acethylcholinesterase Levels of Aedes aegypti Larvae after Exposure to The Pandanus amaryllifolius Leaf Extracts Anin, Lidya; Adrianto, Hebert; Silitonga, Hanna Tabita Hasianna; Indrasari, Setyarina; Sari, Kartika Buana
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 12, No 1 (2025): FEBRUARY
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.12.1.2025.31-39

Abstract

Background:  Dengue fever is a disease transmitted by Ae. aegypti. Controlling mosquitoes can use temephos. Temephos larvicides act primarily on the enzyme acetylcholinesterase (AChE) by inhibiting this enzyme. Temephos has drawbacks due to its high risk of resistance, so larvicides from natural ingredients such as pandan leaf extract (P. amaryllifolius) can be an alternative. The mechanism of action of P. amaryllifolius larvicide is still unclear.Objective: This study aims to ascertain how LC85 pandan leaf methanol extract affects AChE levels in Ae. aegypti.Methods: This is an actual experiment design with only a post-test control group research design. Tests were conducted by treating mosquito larvae with P. amaryllifolius LC85 extract, aquades, and temephos for 24 hours and measuring AChE levels with an ELISA Reader.Results: The results showed that the AChE enzyme levels of P. amaryllifolius LC85 extract had an average AChE enzyme level of 147.19 + 70.87 units/l. The AChE enzyme levels of larvae exposed to P. amaryllifolius LC85, aquades, and temephos significantly differed (p <0.05).Conclusion: P. amaryllifolius has potential as a larvicidal, with a mechanism of action as a neurotoxin.
Keberadaan Toxoplasma gondii Dalam Daging Kambing Yang Dijual Di Pasar Surabaya Barat Berdasarkan Gen Bag-1 Tandean, Victor Setiawan; Adrianto, Hebert; Messakh, Billy Daniel; Yuwono, Victor Kurniawan; Juliasih, Ni Njoman; Santoso, Jemima Lewi; Putri, Firda Aulia; Indrasari, Setyarina
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 10 (2025): Volume 12 Nomor 10
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i10.20687

Abstract

Toksoplasmosis adalah penyakit zoonosis yang disebabkan oleh parasit protozoa Toxoplasma gondii. Parasit dapat menginfeksi manusia dan semua hewan berdarah panas. Manifestasi parah berupa komplikasi yang berpotensi mengakibatkan kebutaan, yaitu Ocular toxoplasmosis (OT). T. gondii dapat ditularkan melalui konsumsi daging yang dimasak kurang matang. Tujuan penelitian adalah mendeteksi T. gondii di dalam daging kambing yang dijual di Surabaya Barat berdasarkan PCR gen BAG1. Penelitian ini adalah penelitian observasional deskriptif. 20 sampel daging kambing diambil dari beberapa pasar di Surabaya Barat dengan kuota sampling. Daging kambing diekstraksi, diamplifikasi PCR dengan gen BAG-1, dan dielektroforesis. Data hasil positif dan negatif dikelompokkan dan dianalisis secara deskriptif. Hasil pemeriksaan didapatkan 10% positif T. gondii dalam daging kambing berukuran 470 bp. Tidak mengkonsumsi daging kambing setengah matang dan memasak daging kambing dengan suhu tinggi dapat mencegah penularan T. gondii.
Co-Authors Anin, Lidya Billy Daniel Messakh Hanna Tabita Hasianna Silitonga Hebert Adrianto Jemima Lewi Santoso Ni Njoman Juliasih Putri, Firda Aulia Sari, Kartika Buana Victor Kurniawan Yuwono Victor Setiawan Tandean