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All Journal JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Indonesian Journal of Biomedicine and Clinical Sciences
Irianiwati
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Histopathology as a key to identify Sezary syndrome in patient with clinical erythroderma Diovani, Sonia; Irianiwati; Febriana, Sri Awalia; Waskito, Fajar; Rizkiani, Dwinanda Almira; Andayani, Raden Roro Rini; Rifko, Ani
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 3 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i3.17293

Abstract

Sezary syndrome (SS) is a rare and aggressive variant of cutaneous T-cell lymphoma (CTCL), characterized by clonal proliferation of malignant T lymphocytes with skin erythroderma. The incidence of CTCL in the United States from 2000 to 2010 reached 10 cases per million people per year, accounts for only 3% of all cases of cutaneous lymphoma. In Indonesia, lymphoma ranks sixth in terms of malignancies, alongside Hodgkin lymphoma and leukemia. We reported a case of 56 y.o. woman presented with blistering lesions that turned into wounds all over her body. Skin biopsy examination revealed characteristic histopathological features, including basket weave-type orthokeratosis, focal parakeratosis, focal acanthosis, and epidermotropism of atypical lymphoid cells with cerebriform nuclei (Sezary cells). Immunohistochemical examination using CD3, CD4, and CD8 showed positive staining in the membrane and cytoplasm of tumor cells within the dermis and epidermis. Sezary syndrome is characterized by clonal expansion of T-helper memory cells in the skin. Histopathology and immunohistochemistry could not differentiate SS from mycosis fungoides. However, histopathological examination could distinguish SS from other differential diagnoses. The diagnosis of SS can be established based on the triad of 1) generalized exfoliative dermatitis involving more than 80% of the body surface area, 2) lymphadenopathy, and 3) the presence of 5% or more malignant T-cells with cerebriform nuclei (Sezary or Lutzner cells) in peripheral blood lymphocytes. In conclusion, we present a case of SS, diagnosed based on the patient's history, physical examination, peripheral blood examination, histopathology, and immunohistochemistry.
Histopathological damage and TNF alpha expression of ileal mucosa in intra-abdominal hypertension rat models Cahyono, Roby; Suhariyanto, Indra Wahono; Sofii, Imam; Irianiwati
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 17, No 2, (2026)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol17.Iss2.art11

Abstract

Background: Intra-abdominal hypertension is a common underestimated clinical condition that can lead to morbidity and mortality. One of the potential complications is ileal mucosa damage and the increase of TNF alpha expression, while early decompression treatment has shown potential benefit to reduce ileal damage. Objectives: To determine the difference in ileal mucosa histopathological damage and TNF alpha expression in intra-abdominal hypertension between non-decompression and decompression conditions.Methods: This study employed experimental design using a post-test only control group. Thirty Wistar albino rats were divided equally into 3 groups according to treatment: a healthy control group (K), an intra-abdominal hypertension group without decompression (P1), and an intra-abdominal hypertension group with decompression treatment (P2). Intra-abdominal hypertension was induced by mechanical obstruction of the anal canal. After intra-abdominal hypertension was induced and treatment was completed, ileal mucosa erosion or ulceration, villous shortening, and TNF alpha expression were observed as parameters of ileal mucosa damage.Results: Ileal mucosa damage and TNF alpha expression are the most frequently observed in the intra-abdominal hypertension group (P1), followed by the decompression treatment group (P2), then the healthy control group (K). Post hoc pairwise comparisons using Fisher's exact tests with Bonferroni correction (α = 0.0167) shows that the decompression treatment group (P2) has lower levels of mucosa erosion or ulceration (p = 0.37) and villous shortening (p = 0.628) compared to the intra-abdominal hypertension group (P1), but neither is statistically significant. Similarly, ordinal logistic regression shows that the decompression treatment group (P2) has no difference in levels of TNF alpha expression compared to the intra-abdominal hypertension group (P1) [OR = 1.38, 95% CI: 0.25–7.65, p = 0.716].Conclusion: There is no difference in ileal mucosa histopathological damage and TNF-alpha expression in intra-abdominal hypertension between non-decompression and decompression conditions.
Co-Authors Andayani, Raden Roro Rini Cahyono, Roby Diovani, Sonia Fajar Waskito Febriana, Sri Awalia Rifko, Ani Rizkiani, Dwinanda Almira Sofii, Imam Suhariyanto, Indra Wahono