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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Berkala Ilmu Kesehatan Kulit dan Kelamin Media Dermato-Venereologica Indonesiana Journal of General Procedural Dermatology and Venereology Indonesia Indonesian Journal of Biomedicine and Clinical Sciences
Febriana, Sri Awalia
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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Allergen profile of facial ACD to cosmetics among patients at Tertiary Referral Hospital in Yogyakarta Alfieri, Alessandro; Indrastuti, Niken; Febriana, Sri Awalia; Pudjiati, Satiti Retno; Waskito, Fajar
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 6, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Cosmetics are a part of life for most of the population and may cause allergic contact dermatitis (ACD), especially on the face, as the primary exposure of cosmetics is on the face area.Methods: This research was conducted retrospectively using secondary data. The research subjects and demographic data were taken from the registered list of patients at Dermatology and Venereology Outpatient Clinic Dr. Sardjito General Hospital with a clinical picture of facial ACD due to cosmetics. Patch tests were carried out from January 2017 to December 2020.Results: From three years period, 26 patients were diagnosed with suspected facial ACD due to cosmetics and underwent patch tests. Of the total 26 patients, 3 patients did not show any reaction to the patch test. On the 23 patients who had reactions on the patch test, there were 66 points on the skin that showed a reaction to allergens. Of the 66 points, 37 points gave a positive reaction picture, with the most common allergen causing the reaction being cobalt(II) chloride hexahydrate (n=4, 10.8%). Then, from 29 points that gave doubtful reactions, the allergen that caused the most reactions was potassium dichromate 0.5% (n=4, 13,8%).Conclusion: The allergens that most often give a positive or doubtful reaction on the patch test of this study are metal compounds (cobalt and potassium dichromate). This study only looks at the patch test that gives a reaction without looking at the clinical relevance related to cosmetics use.
Anti-Retroviral Treatment in dr. Sardjito Central General Hospital Yogyakarta Aquaira, Labitta Pachira; Febriana, Sri Awalia; Rusetiyanti, Nurwestu
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 36 No. 3 (2024): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V36.3.2024.162-167

Abstract

Background: Adverse cutaneous drug reactions (ACDRs) affect 2-3% of hospitalized patients globally, wherein approximately 2% (1 in 1,000 cases) accounted for a severe form of cutaneous drug reactions. Out of all dermatologic diagnoses recorded by HIV patients, eight-point twenty-five percent of patients feature ACDRs, indicating that these patients are 100 times more inclined to develop unfortunate, severe reactions to anti-retroviral treatment. Therefore, there is an urgency in identifying the prevalence of ACDRs in HIV patients taking anti-retroviral treatment. Purpose: The aim of this study is to calculate the prevalence of anti-retroviral drug-induced ACDRs in HIV-positive patients in Central General Hospital, in the time period of January 2015 to December 2017. Methods: This study analyzed inpatient and outpatient medical records from January 2015 to December 2017 in the Dermatology and Venereology Department of dr. Sardjito Central General Hospital, which recorded ART-induced ACDRs manifestations. Result: This study revealed a prevalence of 0.095% of ACDRs as a result of ART administration, with 1.5% HIV-positive patients affected by ACDRs in response to ART medication. A m sex ratio of 2:1 with an average age of 30.4 ± 5.94 years old was found. The most predominant type of ACDR found in HIV-positive patients receiving ART was maculopapular rash (46.7%), while the most common type of drug within the ART regimen to cause such ACDR was Nevirapine (25.8%). Discussion: Nevirapine was the most common type of causative drug, for monotherapy (22.6%) and polytherapy (25.8%).
KOMBINASI FRACTIONAL CO2 DAN PLATELET-RICH FIBRIN SEBAGAI TERAPI SKAR AKNE ATROFI: LAPORAN KASUS Diovani, Sonia; Winarni, Dwi Retno Adi; Febriana, Sri Awalia; Khalidah, Miya; Anggatama, Marcella
Media Dermato-Venereologica Indonesiana Vol 52 No 2 (2025): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v52i2.530

Abstract

   Pendahuluan: Skar akne adalah komplikasi kronis yang sering muncul setelah episode akne inflamasi, yang dapat memberikan dampak psikososial negatif dan sulit diobati. Skar terbentuk akibat kerusakan pada folikel pilosebasea yang disebabkan oleh inflamasi, diikuti dengan penyembuhan jaringan yang tidak sempurna. Oleh karena itu, penting untuk menentukan terapi yang efektif bagi skar akne atrofi. Tujuan laporan kasus ini adalah untuk memberikan gambaran modalitas terapi untuk skar akne atrofi. Kasus: Wanita berusia 32 tahun, mengalami bekas jerawat di wajah, yang mengganggu penampilannya. Pasien ini memiliki riwayat jerawat sejak usia 17 tahun, dengan pemeriksaan dermatologis yang menunjukkan pada wajah tampak skar atrofi tipe ice pick, rolling, dan boxcar, multipel, tanpa akne aktif. Pasien ini diterapi dengan laser fraksional CO2 sebanyak tiga kali dan penggunaan topikal platelet-rich fibrin (PRF) pada malam hari. Hasil terapi menunjukkan perbaikan skar dari derajat sedang menjadi ringan dengan grading Goodman and Baron. Diskusi: Skar atrofi adalah penipisan kulit akibat kurangnya kolagen dan elastin pasca penyembuhan luka, sering terlihat cekung dan umum terjadi setelah jerawat dengan tiga jenis utama: icepick, boxcar, dan rolling. Penanganannya harus disesuaikan dengan jenis skar, seperti penggunaan laser fraksional CO2 yang efektif untuk tipe boxcar dan rolling karena kemampuannya merangsang remodeling kolagen. Kombinasi dengan Platelet-Rich Fibrin (PRF), yang kaya faktor pertumbuhan, dapat mempercepat regenerasi jaringan dan meningkatkan produksi kolagen untuk hasil yang optimal. Kesimpulan: Penanganan skar akne perlu disesuaikan dengan jenis skar dan harapan pasien. Terapi kombinasi dengan laser fraksional CO2 dan PRF memberikan hasil yang memuaskan pada skar akne atrofi derajat sedang.
Histopathology as a key to identify Sezary syndrome in patient with clinical erythroderma Diovani, Sonia; Irianiwati; Febriana, Sri Awalia; Waskito, Fajar; Rizkiani, Dwinanda Almira; Andayani, Raden Roro Rini; Rifko, Ani
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 3 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i3.17293

Abstract

Sezary syndrome (SS) is a rare and aggressive variant of cutaneous T-cell lymphoma (CTCL), characterized by clonal proliferation of malignant T lymphocytes with skin erythroderma. The incidence of CTCL in the United States from 2000 to 2010 reached 10 cases per million people per year, accounts for only 3% of all cases of cutaneous lymphoma. In Indonesia, lymphoma ranks sixth in terms of malignancies, alongside Hodgkin lymphoma and leukemia. We reported a case of 56 y.o. woman presented with blistering lesions that turned into wounds all over her body. Skin biopsy examination revealed characteristic histopathological features, including basket weave-type orthokeratosis, focal parakeratosis, focal acanthosis, and epidermotropism of atypical lymphoid cells with cerebriform nuclei (Sezary cells). Immunohistochemical examination using CD3, CD4, and CD8 showed positive staining in the membrane and cytoplasm of tumor cells within the dermis and epidermis. Sezary syndrome is characterized by clonal expansion of T-helper memory cells in the skin. Histopathology and immunohistochemistry could not differentiate SS from mycosis fungoides. However, histopathological examination could distinguish SS from other differential diagnoses. The diagnosis of SS can be established based on the triad of 1) generalized exfoliative dermatitis involving more than 80% of the body surface area, 2) lymphadenopathy, and 3) the presence of 5% or more malignant T-cells with cerebriform nuclei (Sezary or Lutzner cells) in peripheral blood lymphocytes. In conclusion, we present a case of SS, diagnosed based on the patient's history, physical examination, peripheral blood examination, histopathology, and immunohistochemistry.
ANALISIS COST OF ILLNESS DAN LAMA RAWAT INAP PADA PASIEN STEVENS JOHNSON SYNDROME DAN TOXIC EPIDERMAL NECROLYSIS DARI PERSPEKTIF RUMAH SAKIT DI RSUP DR. SARDJITO YOGYAKARTA Darwis, Darwis; Perwitasari, Dyah Aryani; Febriana, Sri Awalia
Media Farmasi: Jurnal Ilmu Farmasi Vol. 16 No. 2: September 2019
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v16i1.14642

Abstract

Stevens-Johnson Syndrom (SJS) dan Toxic Epidermal Necrolysis (TEN) merupakan suatu reaksi hipesensitivitas akut ditandai dengan nekrosis kutaneus dan masuk 10 besar efek samping terbanyak yang dilaporkan di Indonesia sebesar 3%. Banyaknya terapi dan lama perawatan diRumah sakit berdampak pada meningkatnya morbiditas, mortalitas dan biaya kesehatan. Tujuan dari penelitian inia adalah mengetahui cost of illness dan perbandingan lama rawat inap pada pasien SJS dan TEN akibat penggunaan obat dari perspektif rumah sakit. Design penelitian iniadalah cross sectional study dengan pengambilan data retrospektif. Data yang diambil adalah pasien yang terdiagnosa SJS dan TEN akibat penggunaan obat dan menjalani rawat inap di RSUP Dr. Sardjito Yogyakarta selama periode tahun 2014-2018 sesuai kreteria inklusi daneksklusi. Sebanyak 48 pasien dilibatkan dengan diagnosa SJS sebanyak 41 pasien dan TEN sebanyak 7 pasien. Rata-rata total biaya pasien SJS sebesar Rp. 16.546.233,0224±16.091.819,01889, sedangkan untuk pasien TEN sebesar 14.356.586,2086 ± 6.645.740,75924. Rata-rata lama rawat inap pasien SJS (12,66±5,77 hari) dan TEN (13,29±3,03 hari). Tidak terdapat perbedaan signifikan rata-rata total biaya dan lama rawat inap antar pasien SJS dan TEN dimana nilai p > 0,05. SJS dan TEN tidak terdapat perbedaaan signifikan tetapi dapat menjadi beban biaya cukup tinggi dan peningkatan durasi lama rawat inap bagi pasien.
ANALISIS BIAYA SAKIT PERSPEKTIF MASYARAKAT PADA PENDERITA DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) DI RSUP Dr. SARDJITO YOGYAKARTA Fatkhiya, Musa Fitri; Perwitasari, Dyah Aryani; Febriana, Sri Awalia
Media Farmasi: Jurnal Ilmu Farmasi Vol. 17 No. 1: Maret 2020
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v17i1.15928

Abstract

Penyakit akibat induksi obat merupakan suatu efek yang tidak diinginkan  yang dapat menyebabkan mortalitas maupun morbiditas. Reaksi pada kulit yang mungkin muncul dapat berupa efek ringan hingga berat seperti Severe Cutaneous Adverse Reaction (SCAR) sehingga memerlukan perhatian khusus. SCAR bukan hanya masalah kesehatan tetapi juga menjadi beban keuangan yang signifikan untuk individu yang terkena dampak. Salah satu variasi SCAR yang memiliki periode latensi yang panjang adalah DRESS (Drug Reaction With Eosinophilia and Systemic Symptom). Penelitian ini bertujuan untuk mengetahui rata-rata biaya medis langsung, biaya non medis langsung dan biaya tidak langsung pada pasien DRESS. Pengambilan data dalam penelitian ini secara cohort retrospective di RSUP Dr. Sardjito Yogyakarta tahun 2015-2018 pada pasien DRESS akibat induksi NSAID, antibiotik, antikonvulsan, antiretroviral, antituberkulosis berdasarkan data rekam medis, data akuntansi serta CRF. Hasil data dianalisis secara deskriptif dengan Microsoft office excel. Rata-rata biaya medis langsung rawat inap sebesar Rp. 11.643.405 dengan komponen biaya tertinggi adalah biaya obat (31%),  biaya tindakan medis (27%), biaya laboratorium (24%), biaya akomodasi (15%) dan biaya lainnya (3%). Biaya rawat jalan  sebesar Rp. 1.027.894 dengan komponen tertinggi yaitu biaya tindakan medis (39%), biaya laboratorium (36%), biaya obat (14%), biaya lainnya (6%) dan terendah adalah biaya transportasi (5%). Rata-rata biaya non medis langsung sebesar Rp 491.035 dan biaya tidak langsung adalah sebesar Rp. 1.675.369 yang merupakan biaya loss income. Biaya medis langsung merupakan biaya tertinggi dibandingkan biaya non medis langsung dan biaya tidak langsung.
Validity and Reliability of the Indonesian Version of Nordic Occupational Skin Questionnaire 2002 (NOSQ-2002) Paramita, Listya; Waskito, Fajar; Prawiratama, Dikky; Indrastuti, Niken; Rayinda, Tuntas; Febriana, Sri Awalia
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 9, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Epidemiological data on occupational hand eczema in Indonesia is still limited, partly because there are no valid and reliable instruments in the Indonesian language as a means of survey. This study aims to translate the Nordic Occupational Skin Questionnaire 2002 (NOSQ-2002) into the Indonesian language and assess the validity and reliability of the Indonesian NOSQ-2002 as an instrument for epidemiological surveys and screening of occupational hand eczema. Methods: The original English version of NOSQ-2002 was translated into the Indonesian language following the standard procedure of translation. The Indonesian NOSQ-2002 version, which had been collectively approved, was subsequently completed by a group of 194 textile employees from PT. Panca Persada Mulia-PANDATEX in Magelang, Central Java, Indonesia. Validity was assessed using Pearson correlation for each question with the total score. Reliability was evaluated using Cronbach's alpha values. The sensitivity and specificity of the Indonesian NOSQ-2002 screening were determined by comparing results with those of examination by the examining physician as the gold standard. Results: Pearson correlation values for each question range from 0.252 to 0.905, all surpassing the r table value, indicating questions in NOSQ-2002 are valid. Reliability NOSQ-2002 rated good (reliable), with a Cronbach's alpha of 0.933. The Indonesian NOSQ-2002 version demonstrates a sensitivity of 93.3% and specificity of 98.8% for screening occupational hand eczema. Conclusion: The Indonesian version of NOSQ-2002 is a valid and reliable instrument for use in epidemiological surveys and screening of occupational hand eczema.
Co-Authors Alfieri, Alessandro Andayani, Raden Roro Rini Anggatama, Marcella Aquaira, Labitta Pachira darwis darwis, darwis Diovani, Sonia Dyah Aryani Perwitasari Fajar Waskito Fatkhiya, Musa Fitri Irianiwati Khalidah, Miya Niken Indrastuti Paramita, Listya Prawiratama, Dikky Rayinda, Tuntas Rifko, Ani Rizkiani, Dwinanda Almira Rusetiyanti, Nurwestu Satiti Retno Pudjiati Satiti Retno Pudjiati Winarni, Dwi Retno Adi