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All Journal Media Dermato-Venereologica Indonesiana Indonesian Journal of Biomedicine and Clinical Sciences
Andayani, Raden Roro Rini
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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Penile squamous cell carcinoma related to high risk HPV infection Harsono, Erliana Tantri; Siswati, Agnes Sri; Diovani, Sonia; Andayani, Raden Roro Rini; Dyah Ayu Mira Oktarina
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 2 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i2.17119

Abstract

Penile cancer is an uncommon form of malignancy, with squamous cell carcinoma (SCC) being the most common subtype. Human papillomavirus (HPV) infection is strongly associated with the development of penile SCC, particularly strains 16 and 18. This report presents two cases of penile SCC related to HPV type 18 infection and discusses the diagnosis and role of HPV in penile cancer. It aims to illustrate the clinical presentation and diagnostic challenges of penile SCC, with emphasis on the role of HPV infection. Case 1 involves a 41 yo man with a verrucous mass on the glans penis, diagnosed as well-differentiated SCC, with HPV type 18 detected. Case 2 is a 54 yo man presenting with multiple ulcerative plaques on the distal glans, also diagnosed as SCC with HPV type 18. Penile SCC can be classified into HPV-associated and non-HPV-associated subtypes. The HPV-associated SCC, more commonly seen in younger patients, is driven by viral oncogenes E6 and E7, which disrupt tumor suppressor proteins. The pathogenesis is similar to that seen in cervical cancer. Diagnosis is confirmed through histopathology and genotyping, while treatment involves surgical excision, with possible radiotherapy and chemotherapy depending on lymph node involvement. Early detection and diagnosis of penile SCC are critical for effective treatment. The HPV infection plays a significant role in the pathogenesis of penile SCC, highlighting the importance of HPV vaccination in prevention. Multidisciplinary management is essential for improving patient outcomes
ONSET KEKAMBUHAN PADA PASIEN PSORIASIS VULGARIS PASKA TERAPI INJEKSI KE-8 SECUKINUMAB DI RSUP DR. SARDJITO YOGYAKARTA PERIODE 2022-2024 Harsono, Erliana Tantri; Waskito, Fajar; Siswati, Agnes Sri; Andayani, Raden Roro Rini; Khalidah, Miya
Media Dermato-Venereologica Indonesiana Vol 52 No 2 (2025): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v52i2.528

Abstract

   Pendahuluan: Psoriasis merupakan penyakit autoimun kulit inflamasi kronis yang ditandai oleh hiperproliferasi epidermis. Terapi agen biologis seperti secukinumab digunakan untuk psoriasis derajat berat dan sekitar 4,6% pasien psoriasis vulgaris di RSUP Dr. Sardjito mendapat terapi secukinumab. Terkait asuransi kesehatan nasional, pemberian injeksi subkutan Secukinumab diberikan sebanyak 8 kali untuk satu pasien. Setelah penghentian terapi agen biologis seringkali psoriasis mengalami kekambuhan. Mengetahui awitan kekambuhan pasien psoriasis pasca terapi injeksi ke-8 secukinumab 300 mg di RSUP Dr. Sardjito serta faktor yang mempengaruhi kekambuhan sehingga dapat menjadi data pendukung penelitian lebih lanjut. Metode: Rancangan penelitian adalah deskriptif. Data diperoleh dari catatan medik elektronik pasien dengan diagnosis psoriasis vulgaris yang telah selesai terapi secukinumab 300 mg sebanyak 8 kali injeksi di Poliklinik Kulit dan Kelamin RSUP Dr. Sardjito periode 2022-2024. Hasil: Total subyek pada studi ini adalah 12. Awitan kambuh ≤ 6 bulan paska terapi secukinumab didapatkan pada 8 pasien (66,7%). Pasien dengan awitan kambuh ≤ 6 bulan paska terapi secukinumab yang memiliki indeks massa tubuh ≥ 25 sebanyak 8 pasien (66,7%). Pasien dengan awitan kambuh ≤ 6 bulan paska terapi secukinumab dengan awitan terdiagnosis psoriasis dini < 40 tahun sebanyak 7 pasien (58,3%). Kesimpulan: Kekambuhan psoriasis paska terapi secukinumab dengan awitan kambuh ≤ 6 bulan lebih banyak terjadi dengan rerata awitan kekambuhan adalah 18 minggu. Awitan kambuh ≤ 6 bulan lebih banyak terjadi pada pasien dengan awitan dini psoriasis dan obesitas. Diperlukan penelitian lebih lanjut terkait faktor risiko kekambuhan dan mekanisme terjadinya kekambuhan paska terapi secukinumab atau agen biologis. 
A rare case of syringocystadenoma papilliferum: clinical and histopathological insights Andayani, Raden Roro Rini; Pudjiati, Satiti Retno; Harsono, Erliana Tantri; Rizkiani, Dwinanda Almira; Hanggoro Tri Rinonce; Rita Cempaka; Indra Wahono; Siti Isya Wahdini; Dyah Ayu Mira Oktarina
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 3 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i3.17146

Abstract

Syringocystadenoma papilliferum (SCAP) is a rare benign adnexal neoplasm originating from apocrine or eccrine sweat glands, first reported by Stokes in 1917. Clinically, SCAP manifests in various forms such as nodules, plaques, or warts, predominantly affecting the scalp in adolescents or children. Histopathologically, it is characterized by papillary and ductal invaginations lined with a two-layered epithelium. This condition can be present at birth or emerge during puberty. We present a 19-year-old female with a congenital, pinkish-brown, wart-like lesion on her scalp that progressively enlarged and spread to the face. Physical examination revealed a verrucous plaque with central erosion, extending from the temporal scalp to the lateral face. Dermoscopy showed papillary structures with defined lesion borders, while histopathological findings confirmed SCAP. The patient underwent surgical excision, and no new lesions were detected during a 3 mo follow-up. Syringocystadenoma papilliferum is often confused with other neoplasms such as sebaceous nevus or verruca vulgaris, but its definitive diagnosis relies on histopathology. The tumor’s characteristic features include cystic invaginations into the dermis with a two-layered epithelium, differentiating it from other conditions. Surgical excision remains the treatment of choice to prevent potential malignant transformation and improve cosmetic outcomes. Syringocystadenoma papilliferum, though rare, can be effectively managed through timely diagnosis and surgical excision. In this case, the patient’s postoperative outcome was favorable, with no recurrence of the lesion. Histopathological evaluation is crucial for accurate diagnosis and guiding treatment strategies.
Histopathology as a key to identify Sezary syndrome in patient with clinical erythroderma Diovani, Sonia; Irianiwati; Febriana, Sri Awalia; Waskito, Fajar; Rizkiani, Dwinanda Almira; Andayani, Raden Roro Rini; Rifko, Ani
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 3 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i3.17293

Abstract

Sezary syndrome (SS) is a rare and aggressive variant of cutaneous T-cell lymphoma (CTCL), characterized by clonal proliferation of malignant T lymphocytes with skin erythroderma. The incidence of CTCL in the United States from 2000 to 2010 reached 10 cases per million people per year, accounts for only 3% of all cases of cutaneous lymphoma. In Indonesia, lymphoma ranks sixth in terms of malignancies, alongside Hodgkin lymphoma and leukemia. We reported a case of 56 y.o. woman presented with blistering lesions that turned into wounds all over her body. Skin biopsy examination revealed characteristic histopathological features, including basket weave-type orthokeratosis, focal parakeratosis, focal acanthosis, and epidermotropism of atypical lymphoid cells with cerebriform nuclei (Sezary cells). Immunohistochemical examination using CD3, CD4, and CD8 showed positive staining in the membrane and cytoplasm of tumor cells within the dermis and epidermis. Sezary syndrome is characterized by clonal expansion of T-helper memory cells in the skin. Histopathology and immunohistochemistry could not differentiate SS from mycosis fungoides. However, histopathological examination could distinguish SS from other differential diagnoses. The diagnosis of SS can be established based on the triad of 1) generalized exfoliative dermatitis involving more than 80% of the body surface area, 2) lymphadenopathy, and 3) the presence of 5% or more malignant T-cells with cerebriform nuclei (Sezary or Lutzner cells) in peripheral blood lymphocytes. In conclusion, we present a case of SS, diagnosed based on the patient's history, physical examination, peripheral blood examination, histopathology, and immunohistochemistry.
Co-Authors Agnes Sri Siswati Diovani, Sonia Fajar Waskito Febriana, Sri Awalia Hanggoro Tri Rinonce Harsono, Erliana Tantri Indra Wahono Irianiwati Khalidah, Miya Oktarina, Dyah Ayu Mira Rifko, Ani Rita Cempaka Rizkiani, Dwinanda Almira Satiti Retno Pudjiati Satiti Retno Pudjiati Siti Isya Wahdini