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All Journal PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Nightingale: Journal of Nursing
Edwin Lewis
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Medicine & Pharmacology Nursing

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Journal : PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA

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Aktivitas Anti Helmintik Infusa Biji Pepaya (Carica papaya L.) terhadap Cacing Ascaris Suum (Studi in Vitro) Edwin Lewis; Hafiz Muchti Kurniawan; Dhanny Jovindho; Andre Budi
PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Vol. 2 No. 2 (2023): PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA
Publisher : Program Studi Farmasi UNAJA

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Abstract

Ascaris suum infection remains a significant problem in both veterinary and human health, particularly in areas with poor sanitation. The use of synthetic anthelmintics faces challenges such as resistance and adverse side effects, prompting the search for alternative treatments from natural sources. This study aimed to evaluate the anthelmintic activity of papaya (Carica papaya L.) seed infusion against Ascaris suum through an in vitro approach. Papaya seeds were dried, ground, and extracted using hot water infusion at 90°C. The assay involved immersing A. suum worms in various infusion concentrations (10%, 20%, 30%, and 40%) and observing them at 1, 3, and 6-hour intervals to determine paralysis and mortality times. The results showed that papaya seed infusion exhibited significant concentration- and time-dependent anthelmintic activity. The 40% concentration produced the strongest effect, causing paralysis within 1 hour and mortality within 3 hours. This activity is likely due to the presence of alkaloids, carpaine, flavonoids, and tannins in papaya seeds, which are toxic to the neuromuscular system of the worms. It can be concluded that Carica papaya seed infusion has potential as a natural anthelmintic agent against Ascaris suum.
Pengaruh Ekstrak Daun Teh terhadap Kualitas Motilitas Spermatozoa Mencit Jantan yang Diberi Paparan Asap Rokok Meki Karolina; Edwin Lewis; Evelyn Angie; Sondang, Silitonga
PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Vol. 2 No. 2 (2023): PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA
Publisher : Program Studi Farmasi UNAJA

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Abstract

Background: Cigarette smoke exposure is a major contributor to male infertility due to its oxidative stress effects on spermatozoa. Tea leaf extract is known to contain high levels of antioxidants that may counteract these effects. Objective: To determine the effect of tea leaf extract on sperm motility quality in male mice exposed to cigarette smoke. Method: This experimental study used 24 male mice divided into four groups: negative control, cigarette smoke exposure, and two treatment groups receiving cigarette smoke exposure along with 200 mg/kg BW and 400 mg/kg BW of tea leaf extract. Sperm motility was assessed using microscopic examination after 14 days of treatment. Results: The group exposed to cigarette smoke alone showed significantly decreased sperm motility. Administration of tea leaf extract at both doses improved sperm motility, with the 400 mg/kg BW group showing a motility value close to the negative control. Conclusion: Tea leaf extract significantly improves sperm motility in mice exposed to cigarette smoke, likely due to its antioxidant content.
Co-Authors Andre Budi Dhanny Jovindho Evelyn Angie Hafiz Muchti Kurniawan Meki Karolina Sondang, Silitonga Zaimah Hilal