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All Journal Jurnal Biologi Tropis JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Fadhila, Luthfiya Nur
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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CRISPR : ERA BARU TERAPI PENYAKIT PERNAPASAN: MENGATASI PENYAKIT PERNAPASAN DENGAN CRISPR-CAS9 Fadhila, Luthfiya Nur; Sanjaya, I Kadek Ari
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 10 No 3 (2024): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol. 10.3 2024
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v10i3.762

Abstract

Background: Respiratory diseases are a significant global health burden, affecting the quality of life of millions of people worldwide. Genetic therapy using CRISPR-Cas9 technology has become a paradigm shift in the treatment of respiratory diseases. This article presents a comprehensive literature review on the use of CRISPR-Cas9 in addressing respiratory diseases, including cystic fibrosis, chronic obstructive pulmonary disease (COPD), and SARS-CoV. This review includes an introduction that provides background on the importance of respiratory disease therapy and the potential of CRISPR-Cas9 in overcoming these challenges. Methods: The literature search method was conducted through scientific databases such as PubMed, Google Scholar, and Scopus. The results reveal that CRISPR-Cas9 can be used to edit genes related to respiratory diseases, reduce inflammation, excessive mucus production, and lung tissue damage, as well as detect the presence of these diseases. Discussion: The discussion highlights the effectiveness of CRISPR-Cas9 based on experimental studies on animal models and in vitro experiments. Challenges that need to be addressed include the efficiency and precision of the technology, long-term safety, and effective delivery. Conclusion: The potential of CRISPR-Cas9 as a therapy for respiratory diseases emphasizes the need for further research and technological development to optimize the effectiveness and safety of this therapy. Thus, breakthroughs in respiratory disease therapy with CRISPR-Cas9 have the potential to improve the health and well-being of the global population. Keywords: CRISPR-Cas9, gene editing, genetic therapy, respiratory diseases
Characteristics and Therapeutic Patterns of Hyperthyroidism in Eastern Indonesia: A Hospital-Based Study Rahmatullah, Alif Rizki; Fadhila, Luthfiya Nur; Mussyafa, Aulia Putri; Wulandari, Inayah; Tunairin, Siti Raodatul Jannah; Gunawan, Aulya Khalisha; Nurmawaddah, Intan; Ningrum, Sania Tresna; Rahadian A., M. Fathir; Kusuma P, I Putu Aryana; Rifki, Muhammad
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10431

Abstract

Hyperthyroidism, a condition of excessive thyroid hormone production, presents significant diagnostic and management challenges worldwide. Its clinical spectrum is broad, influenced by etiology, patient demographics, and regional factors. This study was conducted to provide a detailed description of the clinical characteristics, demographic profile, and management patterns of hyperthyroid patients at Dr. (H.C) Ir. Soekarno Regional General Hospital, a tertiary care center in Bangka Belitung Province. This research utilized a descriptive observational method with a cross-sectional design. Data were retrospectively collected from the medical records of 83 patients diagnosed with hyperthyroidism between January and December 2024. The collected variables included age, gender, clinical manifestations, laboratory findings, and prescribed therapeutic regimens. The analysis revealed a significant female predominance (86.7%) among patients, with the majority falling into the >35 years age group (56.6%), confirming established epidemiological trends. The most prevalent clinical findings were palpitations (90.4%), goiter (85.5%), and unexplained weight loss (78.3%). Graves' disease was identified as the primary etiology in 72.3% of cases. The mainstay of treatment was pharmacotherapy, with Methimazole being the most frequently prescribed antithyroid drug (81.9%), often supplemented with beta-blockers (74.7%) for symptomatic control. This study concludes that the clinical profile of hyperthyroidism at this tertiary hospital aligns with classical presentations, predominantly affecting adult women. The findings underscore the importance of recognizing key symptoms for early diagnosis and affirm that current management practices are consistent with established clinical guidelines.
Co-Authors Gunawan, Aulya Khalisha Kusuma P, I Putu Aryana Muhammad Rifki Mussyafa, Aulia Putri Ningrum, Sania Tresna Nurmawaddah, Intan Rahadian A., M. Fathir Rahmatullah, Alif Rizki Sanjaya, I Kadek Ari Tunairin, Siti Raodatul Jannah Wulandari, Inayah