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Ningrum, Sania Tresna
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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Literature Study: Primary Immunodeficiency Rahmadinna, Sandia Anggun; Yuar, Alana Akmal; Musyafa, Aulia Putri; Hardiant, Excell Defry; Putri, Baiq Ghefira Rojwani; Muliana, Atriska Citra; Salsabila, Septy Rianty Putri; Ningrum, Sania Tresna; Narendra, Ahmad Wahyu; Ramadhania, Yasmine Najla; Habib, Philip
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10168

Abstract

Abnormalities in immune system development and function result in increased susceptibility to infection and reactivation of latent infections. Other immunodeficiencies can result in mild infections and may first be detected in adulthood. This literature review aims to discuss primary immunodeficiencies, including their definition, causes, treatment, and examples of the diseases they cause. This literature review was compiled through a literature search method by reviewing various scientific journals obtained from databases such as PubMed, Google Scholar, and ScienceDirect. The results Primary immunodeficiency disease (PID) results from immune system defects caused by mutations in the genetic code that codes for components of the body's immune system. PID is broadly classified as either a disorder of adaptive immunity (T-cell, B-cell, or combined immune deficiencies) or innate immunity (phagocyte and complement deficiencies). Patients with PID may experience a variety of lung problems, including recurrent lower respiratory tract infections, lung parenchymal abnormalities, asthma, ventilation abnormalities, and bronchiectasis (BE). In conclusion, primary immunodeficiency disease (PID) refers to a large, heterogeneous group of disorders characterized by abnormalities in the development and/or function of the immune system. These conditions result from immune system defects caused by mutations in the genetic code that codes for components of the body's immune system.
A Literature Review: Acute Pharyngitis and Laryngitis Ningrum, Sania Tresna; Hardian, Excell Defry; Fawaiz, Afdhila Anugerah; Ramdhini, Tisya Nasywa
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10215

Abstract

Acute pharyngitis and laryngitis refer to inflammation of the pharynx and larynx. These illnesses are typically brought on by bacterial or viral infections. Reflux, cancer, allergies, trauma, and poisoning are other less frequent causes. The literature review aims to obtain information related to acute pharyngitis and laryngitis. The method used is systematic literature. The results of the literature review obtained that the pathogen most often causing acute pharyngitis is beta-hemolytic Streptococcus group A. Common symptoms of pharyngitis are a sore or painful throat, an itchy throat, and fever. Acute laryngitis is inflammation that occurs in the larynx area, and its etiology can be divided into two: infectious and non-infectious. The most common pathogens causing acute laryngitis are rhinovirus, parainfluenza virus, Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. These pathogens cause symptoms of acute laryngitis such as difficulty swallowing, persistent fever, severe sore throat, coughing up blood, and difficulty breathing. Since the majority of cases have a bacterial origin, the use of antibiotics is the basic management in cases of acute pharyngitis and laryngitis.
Characteristics and Therapeutic Patterns of Hyperthyroidism in Eastern Indonesia: A Hospital-Based Study Rahmatullah, Alif Rizki; Fadhila, Luthfiya Nur; Mussyafa, Aulia Putri; Wulandari, Inayah; Tunairin, Siti Raodatul Jannah; Gunawan, Aulya Khalisha; Nurmawaddah, Intan; Ningrum, Sania Tresna; Rahadian A., M. Fathir; Kusuma P, I Putu Aryana; Rifki, Muhammad
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10431

Abstract

Hyperthyroidism, a condition of excessive thyroid hormone production, presents significant diagnostic and management challenges worldwide. Its clinical spectrum is broad, influenced by etiology, patient demographics, and regional factors. This study was conducted to provide a detailed description of the clinical characteristics, demographic profile, and management patterns of hyperthyroid patients at Dr. (H.C) Ir. Soekarno Regional General Hospital, a tertiary care center in Bangka Belitung Province. This research utilized a descriptive observational method with a cross-sectional design. Data were retrospectively collected from the medical records of 83 patients diagnosed with hyperthyroidism between January and December 2024. The collected variables included age, gender, clinical manifestations, laboratory findings, and prescribed therapeutic regimens. The analysis revealed a significant female predominance (86.7%) among patients, with the majority falling into the >35 years age group (56.6%), confirming established epidemiological trends. The most prevalent clinical findings were palpitations (90.4%), goiter (85.5%), and unexplained weight loss (78.3%). Graves' disease was identified as the primary etiology in 72.3% of cases. The mainstay of treatment was pharmacotherapy, with Methimazole being the most frequently prescribed antithyroid drug (81.9%), often supplemented with beta-blockers (74.7%) for symptomatic control. This study concludes that the clinical profile of hyperthyroidism at this tertiary hospital aligns with classical presentations, predominantly affecting adult women. The findings underscore the importance of recognizing key symptoms for early diagnosis and affirm that current management practices are consistent with established clinical guidelines.
Co-Authors Fadhila, Luthfiya Nur Fawaiz, Afdhila Anugerah Gunawan, Aulya Khalisha Habib, Philip Hardian, Excell Defry Hardiant, Excell Defry Kusuma P, I Putu Aryana Muhammad Rifki Muliana, Atriska Citra Mussyafa, Aulia Putri Musyafa, Aulia Putri Narendra, Ahmad Wahyu Nurmawaddah, Intan Putri, Baiq Ghefira Rojwani Rahadian A., M. Fathir Rahmadinna, Sandia Anggun Rahmatullah, Alif Rizki Ramadhania, Yasmine Najla Ramdhini, Tisya Nasywa Salsabila, Septy Rianty Putri Tunairin, Siti Raodatul Jannah Wulandari, Inayah Yuar, Alana Akmal