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All Journal Jurnal Biologi Tropis Majalah Kedokteran Andalas Jurnal Kedokteran Meditek
Rasya, Salsabila Faiha Wiendra
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Differential Levels and Biological Roles of eNOS and SCUBE1 in Endothelial Dysfunction: A Systematic Review Siregar, Muhammad Abi Ghoffari; Ali, Hirowati; Rahmadian, Rizki; Rasya, Salsabila Faiha Wiendra
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10226

Abstract

Endothelial dysfunction (ED) is a systemic disorder marked by impaired nitric oxide (NO) availability, which is essential for maintaining vascular tone and managing oxidative stress. This dysfunction contributes to vascular pathologies such as atherosclerosis and coronary artery disease (CAD) by fostering vasoconstriction, increased permeability, and inflammatory responses, thereby highlighting the urgent need for biomarkers and interventions aimed at mitigating endothelial dysfunction and its associated risks. The relationship between eNOS and SCUBE1 relates to endothelial function and oxidative stress. This study seeks to clarify the benefits and drawbacks of each biomarker in its capacity as a preventive strategy against endothelial dysfunction. This systematic review, adhering to the PRISMA Checklist, examines evidence on the role of endothelial function and oxidative stress in endothelial dysfunction, with emphasis on the biomarkers eNOS and SCUBE1. Literature searches were conducted in PubMed, ScienceDirect, and Google Scholar, and study quality was appraised based on reported biomarker values and relevance. There were 8 articles with increased eNOS and decreased ROS in several treatments, associated with prevention of endothelial dysfunction. There were 6 articles with increased SCUBE1 in several diseases (breast cancer, STEMI, hashimoto's thyroiditis, peripheral ischemic, pulmonary arterial hypertension, atherosclerosis) being markers of endothelial dysfunction. Both biomarkers can work well according to their release pathways, they can be novel biomarkers of endothelial dysfunction in various diseases. Their main role is on endothelial function, SCUBE1 controls BMPR2 signaling (angiogenic, proliferation, apoptosis) and eNOS focuses on endothelial health through NO production (vasodilation, maintaining vascular tone).
Potensi Terapeutik Tanaman Andalas (Morus macroura Miq.) sebagai Sumber Antioksidan dan Antiinflamasi : Narrative Review Wulandari, Wulandari; Siregar, Muhammad Abi Ghoffari; Rasya, Salsabila Faiha Wiendra; Husna, Annisaul; Elliyanti, Aisyah
Majalah Kedokteran Andalas Vol. 48 No. 4 (2025): MKA October 2025
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v48.i4.p457-465.2025

Abstract

Latar Belakang: Tanaman Andalas (Morus macroura Miq.) merupakan salah satu tanaman asli Indonesia yang dianggap sebagai maskot Sumatera Barat. Tanaman herbal ini kaya akan senyawa bioaktif. Tujuan: Mengetahui potensi terapeutik dan preventif tanaman andalas sebagai sumber antioksidan dan antiinflamasi. Metode: Pendekatan narrative review, sumber literatur dari Pubmed, Google Scholar, dan Science Direct. Penulis menggunakan kata kunci Morus macroura Miq. atau andalas, potensi terapeutik, antioksidan, antiinflamasi. Kriteria inklusi berupa artikel sesuai dengan tema penelitian, artikel terindeks scopus, serta diterbitkan tahun 2019-2023. Kriteria eksklusi meliputi artikel yang tidak dapat diakses, tidak menjawab jenis review. Hasil: Tanaman andalas berpotensi sebagai antioksidan dengan cara mengurangi indeks stres oksidatif dan meningkatkan pertahanan antioksidan. Tanaman andalas juga berpotensi sebagai antiinflamasi dengan cara menurukan kadar biomarker peradangan dan meningkatkan ekspresi miRNA-223. Kesimpulan: Tanaman andalas berpotensi sebagai sumber antioksidan dan antiinflamasi serta agen terapeutik yang menjanjinkan dalam pengobatan penyakit terkait inflamasi dan stres oksidatif, seperti kolitis ulserativa, kanker, neurotoksisitas, dan lainnya yang memerlukan uji klinis lebih lanjut.
In Vitro Analysis of SCUBE1 Expression in Aortic Vascular Smooth Muscle Cells on Atherosclerosis Progression Rasya, Salsabila Faiha Wiendra; Ali, Hirowati; Yanni, Mefri; Rita , Rauza Sukma; Asri , Aswiyanti; Mahata , Liganda Endo; Putri , Biomechy Oktomalio; Yarni , Sisca Dwi
Jurnal Kedokteran Meditek Vol 32 No 3 (2026): MEI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v32i3.4015

Abstract

Background:  Signal peptide-CUB-EGF domain-containing protein-1 (SCUBE1) is a platelet–endothelial glycoprotein implicated in thrombosis and vascular inflammation, and has been detected within atherosclerotic lesions. Whether vascular smooth muscle cells (VSMCs) upregulate SCUBE1 under inflammatory stimuli remains unclear. Objective:  To quantify SCUBE1 mRNA expression in rat aortic VSMCs following lipopolysaccharide (LPS) exposure in an organ-culture model of atherogenesis. Methods: This study aimed to analyze SCUBE1 expression in aortic VSMCs in atherosclerosis using real-time PCR. This study was a true experimental-post test control group design using organ culture. The aorta from six wistar rats were divided into two groups, consisting of five samples that were not induced with LPS and five samples exposed to LPS at a concentration of 10 µg/mL for 48 hours. Expression of the SCUBE1 gene was then analyzed using real-time PCR. The data was then processed using the dependent T-Test. Results: The result showed LPS increased SCUBE1 transcript levels compared with control (mean ± SD: 0.78 ± 0.22 vs 0.44 ± 0.35), representing a non-significant trend toward induction (p=0.07). These preliminary data are consistent with SCUBE1’s inducibility in inflammatory states and its presence in atherosclerotic tissue. Conclusion: This study revealed increased SCUBE1 gene expression in aortic VSMCs in the LPS-treated group. These data suggest that SCUBE1 has the potential to be a marker of endothelial dysfunction in atherosclerosis.
Co-Authors Aisyah Elliyanti Asri , Aswiyanti Hirowati Ali, Hirowati Husna, Annisaul Mahata , Liganda Endo Muhammad Abi Ghoffari Siregar Putri , Biomechy Oktomalio Rahmadian, Rizki Rita , Rauza Sukma Wulandari Wulandari Yanni, Mefri Yarni , Sisca Dwi