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All Journal Jurnal Biologi Tropis JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Siregar, Muhammad Abi Ghoffari
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Potensi Pemanfaatan Serum Mir 122-5p Sebagai Biomarker Dalam Deteksi Dini Infark Miokard Akut Pada Pasien Lanjut Usia Siregar, Muhammad Abi Ghoffari; Hidayat, Fariz; Rayhansyah, Vito
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 10 No 2 (2024): JIMKI (Jurnal Ilmiah Mahasiswa Kedokteran Indonesia) Volume 10 Nomor 2 Periode O
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v10i2.529

Abstract

Acute myocardial infarction is the first manifestation of CAD which is the leading cause of death worldwide. The increasing incidence is often associated with increasing age where eldery are mostly affected with this disease. Although there are several biomarkers such as troponin I and T in detecting the risk of developing AMI, it has been found that populations over 70 years have elevated troponin I levels and increased troponin T levels in non-AMI cases. Because of that, a specific biomarker that can specifically detect AMI is needed. This literature review is aimed to discuss the possibility by using miR-122-5p serum for specific biomarker in detecting AMI in eldery population. The literature search was conducted based on journal searching related to the topic such as, PubMed, Science Direct, and Google Scholar. Based on the literature research we have done and our topic, we have obtained the results as follows. Pathogenesis of AMI, the underlying mechanism of miR-122-5p in association with AMI, the specificity of miR-122-5p for AMI, and the comparison of miR-122-5p with other AMI biomarkers. From the pathogenesis of AMI, we have obtained the basis of the disease, the underlying mechanism explains the potential relation to AMI and the detection, through the specificity we can see how it may be effective as a biomarker, and the comparison may reveal it’s potential and how it compares to other biomarkers.
Differential Levels and Biological Roles of eNOS and SCUBE1 in Endothelial Dysfunction: A Systematic Review Siregar, Muhammad Abi Ghoffari; Ali, Hirowati; Rahmadian, Rizki; Rasya, Salsabila Faiha Wiendra
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): in Progress
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10226

Abstract

Endothelial dysfunction (ED) is a systemic disorder marked by impaired nitric oxide (NO) availability, which is essential for maintaining vascular tone and managing oxidative stress. This dysfunction contributes to vascular pathologies such as atherosclerosis and coronary artery disease (CAD) by fostering vasoconstriction, increased permeability, and inflammatory responses, thereby highlighting the urgent need for biomarkers and interventions aimed at mitigating endothelial dysfunction and its associated risks. The relationship between eNOS and SCUBE1 relates to endothelial function and oxidative stress. This study seeks to clarify the benefits and drawbacks of each biomarker in its capacity as a preventive strategy against endothelial dysfunction. This systematic review, adhering to the PRISMA Checklist, examines evidence on the role of endothelial function and oxidative stress in endothelial dysfunction, with emphasis on the biomarkers eNOS and SCUBE1. Literature searches were conducted in PubMed, ScienceDirect, and Google Scholar, and study quality was appraised based on reported biomarker values and relevance. There were 8 articles with increased eNOS and decreased ROS in several treatments, associated with prevention of endothelial dysfunction. There were 6 articles with increased SCUBE1 in several diseases (breast cancer, STEMI, hashimoto's thyroiditis, peripheral ischemic, pulmonary arterial hypertension, atherosclerosis) being markers of endothelial dysfunction. Both biomarkers can work well according to their release pathways, they can be novel biomarkers of endothelial dysfunction in various diseases. Their main role is on endothelial function, SCUBE1 controls BMPR2 signaling (angiogenic, proliferation, apoptosis) and eNOS focuses on endothelial health through NO production (vasodilation, maintaining vascular tone).
Co-Authors Fariz Hidayat, Fariz Hirowati Ali, Hirowati Rahmadian, Rizki Rasya, Salsabila Faiha Wiendra Rayhansyah, Vito