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All Journal Jurnal Kesehatan Andalas Jurnal Biologi Tropis Majalah Kedokteran Andalas Health and Medical Journal PREPOTIF : Jurnal Kesehatan Masyarakat Journal Orthopaedi and Traumatology Surabaya (JOINTS) Indonesian Journal of Multidisciplinary Science Frontiers on Healthcare Research
Rahmadian, Rizki
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Public Health Social Sciences

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Profile of Lumbar Spinal Stenosis Patients at Dr. M. Djamil Central Public Hospital from 2018-2022 Akbar, Inasa Faiza; Sahputra, Roni Eka; Elfi, Eka Fithra; Rahmadian, Rizki; Rusjdi, Dina Arfiani; Silvia, Nelmi
(JOINTS) Journal Orthopaedi and Traumatology Surabaya Vol. 13 No. 2 (2024): October 2024
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v13i2.2024.52-60

Abstract

Background: Lumbar Spinal Stenosis (LSS) is a pathological condition characterized by narrowing of the spinal canal in the lower back. In Indonesia, comprehensive data on LSS is currently unavailable. This study aimed to determine the profile of LSS patients at Dr. M. Djamil Central Public Hospital. Methods: This descriptive cross-sectional study utilized medical record data from 122 LSS patients at Dr. M. Djamil Central Public Hospital between 2018 and 2022, selected via consecutive sampling. Inclusion criteria included age over 18 years and a confirmed LSS diagnosis. Exclusion criteria included incomplete medical records, lack of MRI results, and follow-up visits without treatment. Univariate analysis was performed using SPSS 25.0 to describe patient characteristics, causative factors, symptoms, location of stenosis, and management type. Results: In this study, 122 samples met the inclusion and exclusion criteria. LSS was mainly found in patients aged 60-69 years (33.6%) and in women (59%). Most LSS patients had obesity (BMI category I, 32%). Many LSS patients were housewives (42.62%) and reported light work activity (63.1%). The most common cause of LSS was degenerative factors (59%). The main symptom experienced by LSS patients was lower back pain (94.3%), frequently accompanied by radicular pain (79.5%). The most common location of stenosis was L4-L5 (43.4%). Most LSS patients in this study were managed both conservatively and operatively (70.5%). Conclusion: These findings contribute to a better understanding of LSS prevalence and distribution among patients. Further multicenter studies are needed to establish a comprehensive national LSS profile.
Characteristics of Patients with Thoracolumbar Fractures at Dr. M. Djamil Padang Central General Hospital in 2018-2022 Shafira, Zahra; Sahputra, Roni Eka; Noer, Mustafa; Rahmadian, Rizki; Burhan, Ida Rahmah; Irawati, Lili
(JOINTS) Journal Orthopaedi and Traumatology Surabaya Vol. 14 No. 1 (2025): April 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v14i1.2025.1-9

Abstract

Background: Vertebral fracture is one of the traumas that results in the highest rates of disability and death. Vertebral fractures can occur in various regions, but more than 50% of cases occur in the thoracolumbar region T10-L2. This can be caused by several factors, such as age, gender, and BMI. More than 30% of patients have symptoms of chronic back pain accompanied by neurological deficits. This study discussed the characteristics of patients with thoracolumbar fractures at Dr. M. Djamil Padang Central General Hospital. Methods: This research is an observational descriptive study with a cross-sectional design. Research data were obtained from patient medical records, and the total inclusion sample is 139 patients with thoracolumbar fracture at Dr. M. Djamil Padang Central General Hospital in the 2018-2022 period. The data were processed and displayed as frequency distributions. Results: This research showed that the incidence of thoracolumbar fractures is found in 72 patients, with 72 being women. Mainly occurred between 15-64 years of age (73.4%), with 61.2% of cases caused by low energy trauma. As many as 62.6% of the patients received conservative management accompanied by surgery. Conclusion: This study concluded that thoracolumbar fractures often occur in women of reproductive age. The most common etiology is a fall from a height of less than three meters.
Functional Outcome of Post Anterior Cruciate Ligament Reconstruction Patients in Dr. M. Djamil Central General Hospital Padang 2020-2022 Rinaldiansyah; Rahmadian, Rizki; Fortuna, Fory; Eka Sahputra, Roni; Ramda Ilhami, Yose; Renita Rusjdi, Selfi
(JOINTS) Journal Orthopaedi and Traumatology Surabaya Vol. 14 No. 1 (2025): April 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v14i1.2025.10-18

Abstract

Background: The anterior cruciate ligament (ACL) is the main stabilizer of the knee joint. The incidence of ACL injuries is quite high, especially in individuals who participate in sports. ACL injuries result in knee instability, hindering daily activities and sports participation. This study aimed to determine the functional outcomes of patients who have undergone ACL reconstruction. Methods: This study was descriptive, with a cross-sectional approach, and used medical record data from Dr. M. Djamil Central General Hospital Padang. The total sampling technique was used from patients after ACL reconstruction in 2020-2022. Patients with bilateral knee injuries, multiple ligament injuries, or revision reconstruction were excluded from the study. The samples were contacted to determine their functional outcome by filling out the Lysholm Knee Score. Results: This study analyzed 27 patients, with 77.8% in the 19-44 age group, and no patients were over 60 years old. This study identified 85.2% of male patients with sports-related injuries being the most common (70.4%). The non-dominant knee was injured more frequently (51.9%). Functional outcomes, as assessed by the Lysholm Knee Score, showed excellent, good, and moderate results in 37 %, 29.6%, and 33.3% of patients, respectively. Conclusions: ACL reconstruction was most frequently performed in the adult population aged 19–44 years, predominantly in males. Sports-related injuries were the primary cause, with the majority of reconstructions involving the non-dominant knee. The average patient achieved good functional outcomes after ACL reconstruction.
Perbedaan Derajat Adhesi Peritendinous Setelah Pemberian Platelet Rich Plasma (PRP) Terhadap Penyembuhan Ruptur Tendon Achilles Tikus Wistar Ananda, Gita Putri; Rahmadian, Rizki; Intan, Shinta Ayu; Rikarni, Rikarni; Rusjdi, Selfi Renita
Jurnal Kesehatan Andalas Vol. 14 No. 1 (2025): March 2025
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Platelet-rich plasma (PRP) has been identified as a potential agent to enhance the tendon healing process and prevent complications such as adhesion and tendon displacement after surgery. Objective: To determined the difference in the degree of peritendinous adhesion after administration of platelet-rich plasma (PRP) on the healing of Achilles tendon rupture in Wistar rats. Methods: This study used a post-test only control group experimental design. Tendons in the control group were treated without PRP, while the treatment group received PRP before care. After one week, the degree of peritendinous adhesion was evaluated microscopically using the Tang scoring system. Results: The mean degree of adhesion in the control group was 3.38, and in the treatment group it was 3.83. The independent t-test yielded a non-significant value of 0.411 (p > 0.05). Conclusion: There was no significant difference in the degree of peritendinous adhesion in Achilles tendon rupture healing of Wistar rats between the group given PRP and the group not given PRP. Keywords: peritendinous adhesion, PRP, tendon rupture, Tang score
Efek Pemberian Ekstrak Daun Sungkai (Peronema canescens Jack) Terhadap Proliferasi dan Migrasi Sel Kanker Serviks HeLa Rahmawati, Meilisa; Arisanty, Dessy; Rahmadian, Rizki; Yerizel, Eti; Rusjdi, Dina Arfiani; Rahmatini, Rahmatini
Majalah Kedokteran Andalas Vol. 47 No. 4 (2024): MKA October 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v47.i4.p383-398.2024

Abstract

Tujuan: mengetahui pengaruh pemberian ekstrak daun sungkai dalam menghambat proliferasi dan migrasi sel HeLa. Metode: Penelitian ini merupakan penelitian eksperimental yang menggunakan 24 disk kultur sel HeLa yang konfluens. Sampel dibagi menjadi 4 kelompok (K,P1,P2 dan P3). Kelompok perlakuan diberikan ekstrak daun sungkai dengan konsentrasi IC25, IC50, dan IC75 yang diinkubasi selama 72 jam. Analisis data menggunakan uji One Way ANOVA dan Post Hoc Bonferroni. Hasil: Rerata jumlah sel proliferatif yang didapatkan pada kelompok K, P1, P2, dan P3 berturut-turut adalah 12,1 x 105, 8,94 x 105, 6,14 x 105 dan 5,04 x 105. Rerata migrasi jumlah sel yang berkumpul pada zona scratch pada kelompok K, P1, P2, dan P3 berturut-turut adalah 49,.0, 237,8, 210,5, dan 100,7. Didapatkan perbedaan yang bermakna tiap kelompok pada uji proliferasi dan migrasi dengan nilai p = 0,000 (p < 0,05). Kesimpulan: Terdapat pengaruh pemberian ekstrak daun sungkai terhadap proliferasi dan migrasi sel HeLa. Perbedaan bermakna ditemukan pada kelompok kontrol dan kelompok perlakuan dengan konsentrasi ekstrak IC25, IC50, dan IC75.
Differential Levels and Biological Roles of eNOS and SCUBE1 in Endothelial Dysfunction: A Systematic Review Siregar, Muhammad Abi Ghoffari; Ali, Hirowati; Rahmadian, Rizki; Rasya, Salsabila Faiha Wiendra
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10226

Abstract

Endothelial dysfunction (ED) is a systemic disorder marked by impaired nitric oxide (NO) availability, which is essential for maintaining vascular tone and managing oxidative stress. This dysfunction contributes to vascular pathologies such as atherosclerosis and coronary artery disease (CAD) by fostering vasoconstriction, increased permeability, and inflammatory responses, thereby highlighting the urgent need for biomarkers and interventions aimed at mitigating endothelial dysfunction and its associated risks. The relationship between eNOS and SCUBE1 relates to endothelial function and oxidative stress. This study seeks to clarify the benefits and drawbacks of each biomarker in its capacity as a preventive strategy against endothelial dysfunction. This systematic review, adhering to the PRISMA Checklist, examines evidence on the role of endothelial function and oxidative stress in endothelial dysfunction, with emphasis on the biomarkers eNOS and SCUBE1. Literature searches were conducted in PubMed, ScienceDirect, and Google Scholar, and study quality was appraised based on reported biomarker values and relevance. There were 8 articles with increased eNOS and decreased ROS in several treatments, associated with prevention of endothelial dysfunction. There were 6 articles with increased SCUBE1 in several diseases (breast cancer, STEMI, hashimoto's thyroiditis, peripheral ischemic, pulmonary arterial hypertension, atherosclerosis) being markers of endothelial dysfunction. Both biomarkers can work well according to their release pathways, they can be novel biomarkers of endothelial dysfunction in various diseases. Their main role is on endothelial function, SCUBE1 controls BMPR2 signaling (angiogenic, proliferation, apoptosis) and eNOS focuses on endothelial health through NO production (vasodilation, maintaining vascular tone).
Pengaruh Video Animasi terhadap Perilaku Pencegahan COVID-19 pada Anak Sekolah Dasar Yanti, Farah Sevnell; Hanum, Fathiya Juwita; Firdawati, Firdawati; Rahmadian, Rizki; Amir, Arni; Nurhajjah, Siti
Health and Medical Journal Vol 5, No 2 (2023): HEME May 2023
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v5i2.1289

Abstract

Pendahuluan: Coronavirus Disease (COVID-19) merupakan penyakit infeksi virus SARS-CoV-2 yang menyerang sistem pernapasan manusia. Penyakit ini memiliki tingkat penularan yang tinggi sehingga diperlukan upaya pencegahan untuk menghambat penularannya. Anak sekolah dasar termasuk kelompok yang berisiko menjadi carrier dan menularkan virus ini kepada orang lain meskipun tidak bergejala. Promosi kesehatan pada kelompok ini penting dilakukan melalui media penyampaian informasi yang menarik agar mereka menyadari pentingnya melakukan upaya pencegahan penyakit COVID-19. Tujuan penelitian: Untuk melihat pengaruh video animasi tentang pencegahan COVID-19 terhadap pengetahuan, sikap, dan tindakan siswa sekolah dasar kelas 3-5 SDN 10 Lambung Bukit Padang. Metode: Ini adalah penelitian analitik menggunakan pre experimental design dengan one-group pretest-posttest design. Terdapat sebanyak 52 sampel siswa SDN 10 Lambung Bukit Padang. Data diambil menggunakan kuesioner dan dianalisis dengan uji wilcoxon signed rank test. Hasil: Sebelum dilakukan intervensi mayoritas sampel memiliki tingkat pengetahuan yang kurang (48,1%), sikap yang baik (61,5%) dan tindakan yang baik (75,0%). Setelah diberikan intervensi, mayoritas memiliki tingkat pengetahuan yang cukup (57,7%), sikap yang baik (84,6%) dan tindakan yang baik (84,6%). Hasil analisis bivariat pre dan post intervensi menggunakan Uji Wilcoxon mendapatkan nilai p-value < 0,05 untuk variabel pengetahuan, sikap, dan tindakan. Hal ini menunjukkan setelah dilakukan intervensi terdapat perubahan yang bermakna (signifikan) dari  pengetahuan, sikap, dan tindakan responden tentang pencegahan COVID-19. Kesimpulan: Terdapat pengaruh video animasi tentang pencegahan COVID-19 terhadap pengetahuan, sikap, dan tindakan siswa sekolah dasar kelas 3-5 SDN 10 Lambung Bukit.
PENGARUH PEMBERIAN KRIM SEKRETOM3 TERHADAP EKSPRESI GEN CARTILLAGE OLIGOMERIC MATRIX PROTEIN PADA TIKUS OSTEOARTHRITIS SECARA IN VIVO Meksiko, Riki; Marlina; Rahmadian, Rizki
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 2 (2024): AGUSTUS 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i2.27772

Abstract

Tujuan penelitian ini adalah untuk menganalisis Pengaruh pemberian krim sekretom Terhadap Ekspresi Gen Cartillage Oligomeric Matrix Protein Pada Tikus Osteoarthritis Secara In Vivo yang terdiri dari kelompok kontrol positif, dosis 5%, dosis 10% dan dosis 15% dengan menggunakan metode realtime-pcr. Penelitian ini menggunakan sel punca MSC dari jaringan adiposa yang diproses hingga fase keempat (P4) dan dibuat menjadi krim MSC-CM dengan emulgator Olivem® 1000. Model osteoartritis dibuat pada tikus menggunakan Monosodium Iodoasetat (MIA), dan kerusakan sendi dianalisis secara histopatologi. Krim sekretom diterapkan pada tikus selama 2 minggu. Data dianalisis dengan uji Shapiro-Wilk, Levene, dan SPSS Ver 18 untuk mengevaluasi ekspresi gen COMP.  Hasil penelitian ini melibatkan penggunaan sel punca MSC dari jaringan adiposa yang telah disubkultur untuk menyiapkan media kultur dan krim MSC-CM. Sel-sel yang telah memasuki fase keempat (P4) diproses dan disimpan untuk digunakan dalam pembuatan krim yang mengandung faktor pertumbuhan sel punca. Krim MSC-CM diformulasikan dengan emulgator Olivem® 1000 dan minyak jeruk untuk meningkatkan penetrasi dan stabilitas. Penelitian juga mengevaluasi efek krim pada tikus dengan osteoartritis, mengamati peningkatan ekspresi gen Cartilage Oligomeric Matrix Protein (COMP) setelah pemberian krim. Hasil menunjukkan bahwa krim sekretom dapat meningkatkan ekspresi COMP dan menunjukkan potensi perbaikan tulang rawan, meskipun tidak signifikan secara statistik.
The Efficacy of Application of Oral Antibiotic Loaded Polymethyl Methacrylate Against Staphylococcus aureus Rahmadian, Rizki; Edison, Ebill Fuji; Kaharudin, Kaharudin; Irrahmah, Miftah; Putra, Andani Eka
Indonesian Journal of Multidisciplinary Science Vol. 2 No. 9 (2023): Indonesian Journal of Multidisciplinary Science
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/ijoms.v2i9.543

Abstract

Chronic osteomyelitis is still common in the developing world and presents a continuing therapeutic challenge. Local antibiotic therapy is performed as the first stage treatment algorithm for 4 to 8 weeks. Given the high patient morbidity, mortality, and economic burden caused by osteomyelitis and its treatment, it is important to find another effective and efficient treatment.  Intravenous antibiotics and polymethylmethacrylate (PMMA) combination have shown effectiveness, but the potential of oral antibiotics and PMMA combination is still rare and is debatable. It aimed to compare efficacy among oral antibiotic-loaded PMMA in many concentrations (5%, 10%, 20%) and controls (0%) against Staphylococcus aureus. This experimental study was conducted in the Microbiology Department of Andalas University. The object was S. aureus. We used ten oral antibiotics and compared among its many concentrations (5%, 10%, 20%) and controls (0%).  Data were analyzed by analysis of variance (ANOVA) test. The lowest counts of S. aureus were found in ciprofloxacin 20%, followed by tetracycline 10%, erythromycin 5%, rifampicin 10%, ofloxacin 20%, clindamycin 20%, amoxiclav 20%, cefixime 5%, cotrimoxazole 20%, and chloramphenicol 20% consecutively. All oral antibiotics loaded PMMA in each concentration might reduce the number of colonies up to 90%. A study in 2013 revealed that a combination of several antibiotics and PMMA was proven to be effective. The oral antibiotics loaded PMMA in various concentrations have a significant bactericidal effect on the growth of S. aureus and able to reduce the number of S. aureus.
Unlocking the Potential: A Review of Stem Cell Applications in Regenerative Medicine Musyarifah, Zulda; Rahmadian, Rizki
Frontiers on Healthcare Research Vol. 1 No. 1 (2024)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v1.n1.p31-38.2024

Abstract

Background : Regenerative medicine stands at the forefront of transformative healthcare, offering innovative approaches to address tissue damage and degenerative conditions. Central to this paradigm is the profound impact of stem cell therapy, a dynamic and promising avenue within regenerative medicine. As we navigate the complexities of this evolving field, our systematic literature review seeks to unravel the diverse applications, breakthroughs, and challenges inherent in utilizing stem cells for regenerative purposes Methods : We searched in Science direct, Pubmed, NIH and another e-library with keyword stem cell, application and regenerative medicine. Our review aims to contribute to the ongoing narrative of stem cell therapy in regenerative medicine. Through this exploration, we aspire not only to enhance our understanding but also to guide future research endeavors and clinical applications in this dynamic and promising field. Result : We reviewed the article  with the theme article is stem cell and regenerative medicine. Stem cell therapy consistently demonstrated remarkable efficacy in promoting tissue regeneration. Across applications, stem cells showcased a remarkable versatility in enhancing tissue-specific cell behavior and activating regenerative pathways. his versatility positions stem cells as a promising tool with broad applications in regenerative medicine. Conclusion : This review emphasize the versatility and efficacy of stem cells in diverse regenerative scenarios. Evaluating methodological quality and comparing studies reveal nuanced insights, guiding future research directions. This review provides a comprehensive understanding of the current landscape, paving the way for innovative approaches in regenerative medicine.
Co-Authors Akbar, Inasa Faiza Ananda, Gita Putri Andani Eka Putra Arni Amir Dessy Arisanty Dina Arfiani Rusjdi Edison, Ebill Fuji Eka Fithra Elfi, Eka Fithra Eka Sahputra, Roni Eti Yerizel Fadila, Srigunda Arisya Firdawati, Firdawati Fortuna, Fory Hanum, Fathiya Juwita Hirowati Ali, Hirowati Ida Rahmah Burhan Intan, Shinta Ayu Irrahmah, Miftah Kaharudin Kaharudin Lili Irawati Marlina Meksiko, Riki Mustafa Noer Musyarifah, Zulda Nelmi Silvia Rahmatini . Rahmawati, Meilisa Ramda Ilhami, Yose Rasya, Salsabila Faiha Wiendra Raymond, Benni Rikarni Rikarni Rinaldiansyah Sahputra, Roni Eka Selfi Renita Rusjdi Selfi Renita Rusjdi, Selfi Shafira, Zahra Siregar, Muhammad Abi Ghoffari Siti Nurhajjah, Siti Tofrizal Yanti, Farah Sevnell