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All Journal Jurnal Kesehatan Andalas Jurnal Biologi Tropis Majalah Kedokteran Andalas Journal Orthopaedi and Traumatology Surabaya (JOINTS)
Rahmadian, Rizki
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Profile of Lumbar Spinal Stenosis Patients at Dr. M. Djamil Central Public Hospital from 2018-2022 Akbar, Inasa Faiza; Sahputra, Roni Eka; Elfi, Eka Fithra; Rahmadian, Rizki; Rusjdi, Dina Arfiani; Silvia, Nelmi
Journal Orthopaedi and Traumatology Surabaya Vol. 13 No. 2 (2024): October 2024
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v13i2.2024.52-60

Abstract

Background: Lumbar Spinal Stenosis (LSS) is a pathological condition characterized by narrowing of the spinal canal in the lower back. In Indonesia, comprehensive data on LSS is currently unavailable. This study aimed to determine the profile of LSS patients at Dr. M. Djamil Central Public Hospital. Methods: This descriptive cross-sectional study utilized medical record data from 122 LSS patients at Dr. M. Djamil Central Public Hospital between 2018 and 2022, selected via consecutive sampling. Inclusion criteria included age over 18 years and a confirmed LSS diagnosis. Exclusion criteria included incomplete medical records, lack of MRI results, and follow-up visits without treatment. Univariate analysis was performed using SPSS 25.0 to describe patient characteristics, causative factors, symptoms, location of stenosis, and management type. Results: In this study, 122 samples met the inclusion and exclusion criteria. LSS was mainly found in patients aged 60-69 years (33.6%) and in women (59%). Most LSS patients had obesity (BMI category I, 32%). Many LSS patients were housewives (42.62%) and reported light work activity (63.1%). The most common cause of LSS was degenerative factors (59%). The main symptom experienced by LSS patients was lower back pain (94.3%), frequently accompanied by radicular pain (79.5%). The most common location of stenosis was L4-L5 (43.4%). Most LSS patients in this study were managed both conservatively and operatively (70.5%). Conclusion: These findings contribute to a better understanding of LSS prevalence and distribution among patients. Further multicenter studies are needed to establish a comprehensive national LSS profile.
Characteristics of Patients with Thoracolumbar Fractures at Dr. M. Djamil Padang Central General Hospital in 2018-2022 Shafira, Zahra; Sahputra, Roni Eka; Noer, Mustafa; Rahmadian, Rizki; Burhan, Ida Rahmah; Irawati, Lili
(JOINTS) Journal Orthopaedi and Traumatology Surabaya Vol. 14 No. 1 (2025): April 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v14i1.2025.1-9

Abstract

Background: Vertebral fracture is one of the traumas that results in the highest rates of disability and death. Vertebral fractures can occur in various regions, but more than 50% of cases occur in the thoracolumbar region T10-L2. This can be caused by several factors, such as age, gender, and BMI. More than 30% of patients have symptoms of chronic back pain accompanied by neurological deficits. This study discussed the characteristics of patients with thoracolumbar fractures at Dr. M. Djamil Padang Central General Hospital. Methods: This research is an observational descriptive study with a cross-sectional design. Research data were obtained from patient medical records, and the total inclusion sample is 139 patients with thoracolumbar fracture at Dr. M. Djamil Padang Central General Hospital in the 2018-2022 period. The data were processed and displayed as frequency distributions. Results: This research showed that the incidence of thoracolumbar fractures is found in 72 patients, with 72 being women. Mainly occurred between 15-64 years of age (73.4%), with 61.2% of cases caused by low energy trauma. As many as 62.6% of the patients received conservative management accompanied by surgery. Conclusion: This study concluded that thoracolumbar fractures often occur in women of reproductive age. The most common etiology is a fall from a height of less than three meters.
Functional Outcome of Post Anterior Cruciate Ligament Reconstruction Patients in Dr. M. Djamil Central General Hospital Padang 2020-2022 Rinaldiansyah; Rahmadian, Rizki; Fortuna, Fory; Eka Sahputra, Roni; Ramda Ilhami, Yose; Renita Rusjdi, Selfi
(JOINTS) Journal Orthopaedi and Traumatology Surabaya Vol. 14 No. 1 (2025): April 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v14i1.2025.10-18

Abstract

Background: The anterior cruciate ligament (ACL) is the main stabilizer of the knee joint. The incidence of ACL injuries is quite high, especially in individuals who participate in sports. ACL injuries result in knee instability, hindering daily activities and sports participation. This study aimed to determine the functional outcomes of patients who have undergone ACL reconstruction. Methods: This study was descriptive, with a cross-sectional approach, and used medical record data from Dr. M. Djamil Central General Hospital Padang. The total sampling technique was used from patients after ACL reconstruction in 2020-2022. Patients with bilateral knee injuries, multiple ligament injuries, or revision reconstruction were excluded from the study. The samples were contacted to determine their functional outcome by filling out the Lysholm Knee Score. Results: This study analyzed 27 patients, with 77.8% in the 19-44 age group, and no patients were over 60 years old. This study identified 85.2% of male patients with sports-related injuries being the most common (70.4%). The non-dominant knee was injured more frequently (51.9%). Functional outcomes, as assessed by the Lysholm Knee Score, showed excellent, good, and moderate results in 37 %, 29.6%, and 33.3% of patients, respectively. Conclusions: ACL reconstruction was most frequently performed in the adult population aged 19–44 years, predominantly in males. Sports-related injuries were the primary cause, with the majority of reconstructions involving the non-dominant knee. The average patient achieved good functional outcomes after ACL reconstruction.
Perbedaan Derajat Adhesi Peritendinous Setelah Pemberian Platelet Rich Plasma (PRP) Terhadap Penyembuhan Ruptur Tendon Achilles Tikus Wistar Ananda, Gita Putri; Rahmadian, Rizki; Intan, Shinta Ayu; Rikarni, Rikarni; Rusjdi, Selfi Renita
Jurnal Kesehatan Andalas Vol. 14 No. 1 (2025): March 2025
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Platelet-rich plasma (PRP) has been identified as a potential agent to enhance the tendon healing process and prevent complications such as adhesion and tendon displacement after surgery. Objective: To determined the difference in the degree of peritendinous adhesion after administration of platelet-rich plasma (PRP) on the healing of Achilles tendon rupture in Wistar rats. Methods: This study used a post-test only control group experimental design. Tendons in the control group were treated without PRP, while the treatment group received PRP before care. After one week, the degree of peritendinous adhesion was evaluated microscopically using the Tang scoring system. Results: The mean degree of adhesion in the control group was 3.38, and in the treatment group it was 3.83. The independent t-test yielded a non-significant value of 0.411 (p > 0.05). Conclusion: There was no significant difference in the degree of peritendinous adhesion in Achilles tendon rupture healing of Wistar rats between the group given PRP and the group not given PRP. Keywords: peritendinous adhesion, PRP, tendon rupture, Tang score
Efek Pemberian Ekstrak Daun Sungkai (Peronema canescens Jack) Terhadap Proliferasi dan Migrasi Sel Kanker Serviks HeLa Rahmawati, Meilisa; Arisanty, Dessy; Rahmadian, Rizki; Yerizel, Eti; Rusjdi, Dina Arfiani; Rahmatini, Rahmatini
Majalah Kedokteran Andalas Vol. 47 No. 4 (2024): MKA October 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i10.p1545-1561.2024

Abstract

Tujuan: mengetahui pengaruh pemberian ekstrak daun sungkai dalam menghambat proliferasi dan migrasi sel HeLa.Metode: Penelitian ini merupakan penelitian eksperimental yang menggunakan 24 disk kultur sel HeLa yang konfluens. Sampel dibagi menjadi 4 kelompok (K,P1,P2 dan P3). Kelompok perlakuan diberikan ekstrak daun sungkai dengan konsentrasi IC25, IC50, dan IC75 yang diinkubasi selama 72 jam. Analisis data menggunakan uji One Way ANOVA dan Post Hoc Bonferroni. Hasil: Rerata jumlah sel proliferatif yang didapatkan pada kelompok K, P1, P2, dan P3 berturut-turut adalah 12,1 x 105, 8,94 x 105, 6,14 x 105 dan 5,04 x 105. Rerata migrasi jumlah sel yang berkumpul pada zona scratch pada kelompok K, P1, P2, dan P3 berturut-turut adalah 49,.0, 237,8, 210,5, dan 100,7. Didapatkan perbedaan yang bermakna tiap kelompok pada uji proliferasi dan migrasi dengan nilai p = 0,000 (p < 0,05).Kesimpulan: Terdapat pengaruh pemberian ekstrak daun sungkai terhadap proliferasi dan migrasi sel HeLa. Perbedaan bermakna ditemukan pada kelompok kontrol dan kelompok perlakuan dengan konsentrasi ekstrak IC25, IC50, dan IC75.
Differential Levels and Biological Roles of eNOS and SCUBE1 in Endothelial Dysfunction: A Systematic Review Siregar, Muhammad Abi Ghoffari; Ali, Hirowati; Rahmadian, Rizki; Rasya, Salsabila Faiha Wiendra
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): in Progress
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10226

Abstract

Endothelial dysfunction (ED) is a systemic disorder marked by impaired nitric oxide (NO) availability, which is essential for maintaining vascular tone and managing oxidative stress. This dysfunction contributes to vascular pathologies such as atherosclerosis and coronary artery disease (CAD) by fostering vasoconstriction, increased permeability, and inflammatory responses, thereby highlighting the urgent need for biomarkers and interventions aimed at mitigating endothelial dysfunction and its associated risks. The relationship between eNOS and SCUBE1 relates to endothelial function and oxidative stress. This study seeks to clarify the benefits and drawbacks of each biomarker in its capacity as a preventive strategy against endothelial dysfunction. This systematic review, adhering to the PRISMA Checklist, examines evidence on the role of endothelial function and oxidative stress in endothelial dysfunction, with emphasis on the biomarkers eNOS and SCUBE1. Literature searches were conducted in PubMed, ScienceDirect, and Google Scholar, and study quality was appraised based on reported biomarker values and relevance. There were 8 articles with increased eNOS and decreased ROS in several treatments, associated with prevention of endothelial dysfunction. There were 6 articles with increased SCUBE1 in several diseases (breast cancer, STEMI, hashimoto's thyroiditis, peripheral ischemic, pulmonary arterial hypertension, atherosclerosis) being markers of endothelial dysfunction. Both biomarkers can work well according to their release pathways, they can be novel biomarkers of endothelial dysfunction in various diseases. Their main role is on endothelial function, SCUBE1 controls BMPR2 signaling (angiogenic, proliferation, apoptosis) and eNOS focuses on endothelial health through NO production (vasodilation, maintaining vascular tone).
Co-Authors Akbar, Inasa Faiza Ananda, Gita Putri Burhan, Ida Rahmah Dessy Arisanty Dina Arfiani Rusjdi Eka Fithra Elfi, Eka Fithra Eka Sahputra, Roni Eti Yerizel Fortuna, Fory Hirowati Ali, Hirowati Intan, Shinta Ayu Lili Irawati Mustafa Noer Rahmatini . Rahmawati, Meilisa Ramda Ilhami, Yose Rasya, Salsabila Faiha Wiendra Rikarni Rikarni Rinaldiansyah Sahputra, Roni Eka Selfi Renita Rusjdi Selfi Renita Rusjdi, Selfi Shafira, Zahra Silvia, Nelmi Siregar, Muhammad Abi Ghoffari