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All Journal Majalah Patologi Indonesia Frontiers on Healthcare Research
Safnita, Dewi
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Health Professions Public Health

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And, The, Of, In SOX10 and The Tendency of Perineural Invasion in Salivary Gland Adenoid Cystic Carcinoma: SOX10 and The Tendency of Perineural Invasion Safnita, Dewi; Hilbertina, Noza; Mulyani, Henny; Tofrizal; Khambri, Daan; Yetti, Husna
Majalah Patologi Indonesia Vol. 34 No. 3 (2025): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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ABSTRACT Background Adenoid cystic carcinoma is a malignant salivary gland tumor with unique features, including slow growth, progressive, poor prognosis, recurrence propensity, and perineural invasion tendency. SOX10 is a transcription factor expressed in the majority of tumors. SOX10 overexpression was hypothesized to play an important role in tumor-stroma interactions, especially perineural invasion and histopathological patterns. Method A cross-sectional study was performed using 30 blocks of formalin-fixed embedded specimens previously diagnosed as salivary gland adenoid cystic carcinomas. Perineural invasion and histopathological patterns were evaluated followed by immunohistochemical staining to evaluate SOX10 expression. The staining intensity and proportion of positively stained cells in both tumor and stroma cells were grouped into high and low expression levels. Chi-square tests were used for statistical analysis. Result The cribriform pattern was the most common histopathological pattern in both high and low SOX10 expression. The majority of tumors with high SOX10 expression (66.67% in stroma cells and 73.33% in tumor cells) were found to have more perineural invasion. Conclusion There was a tendency for perineural invasion in tumors with high SOX10 expression, although this was not statistically significant. There was no significant association between SOX10 expression and histopathological pattern.
The Histological Features of Schwannoma in Frozen Section: A Case Report Safnita, Dewi; Mulyani, Henny
Frontiers on Healthcare Research Vol. 1 No. 1 (2024)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v1.n1.p24-30.2024

Abstract

Background: Intraoperative diagnosis by cytological and frozen section procedures is needed in some cases including peripheral nerve specimens. The results of the cytological evaluation and frozen sections can be relied upon to guide the surgeon in making intraoperative decisions. The pathologist provides information on gross and microscopic findings that correlate with the clinical, and radiological. Although the cytology and frozen section diagnosis approach has been carried out in a multidisciplinary manner, there are still limitations in the intraoperative diagnosis of peripheral nerve specimens. Limitations in this procedure can be overcome by understanding and analyzing possible errors and pitfalls during the procedure thereby increasing the accuracy of the diagnosis. Case report: Schwannoma is a nerve sheath tumor consisting of neoplastic cells with Schwann cell differentiation that generally originates from peripheral nerves in the skin and subcutaneous tissue of the head and neck or along the flexor surfaces of the extremities. More than 90% of schwannomas are solitary and sporadic lesions that can affect any age but with a peak incidence in the fourth to sixth decades of life and there is no racial or gender predisposition. Conclusion: Schwannomas often appear as asymptomatic masses or incidental findings. Intraoperative frozen section pathological diagnosis can be used in determining subsequent surgical management.
Co-Authors Daan Khambri henny Mulyani Husna Yetti Noza Hilbertina, Noza Tofrizal