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All Journal International Journal of Public Health Science (IJPHS) Jurnal Penelitian Sains Oto Rhino Laryngologica Indonesiana Majalah Patologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Science Midwifery
henny Mulyani
Fakultas Ilmu Komunikasi
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Correlation of physical activity with cognition and mental health in medical students Riskawati, Yhusi Karina; Rastramadhani, Faresa Aulia; Mulyani, Henny; Rindradi, Ridha Saniyyah; Mahendra, Muhammad Isa; Indradmojo, Christyaji; Nur, Aswaty
International Journal of Public Health Science (IJPHS) Vol 13, No 4: December 2024
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v13i4.23150

Abstract

Low physical activity increases the number of non-communicable diseases. This phenomenon occurs in medical students. This study aimed to determine the correlation between sedentary behavior and physical activity on cognition, mental health, cortisol, and brain derived neurotropic factor (BDNF). Using a cross-sectional design of observational study, eighty-six medical students were involved in this study. The subjects were interviewed to assess cognitive function and depression levels. Saliva was taken to measure cortisol and BDNF level. Bivariate analysis was performed using the Spearman test. Depression is the only variable that correlates significantly with habitual physical activity (p=0.025, r=-0.214). Sedentary behavior has a weak correlation with cognitive failure, anxiety, and depression ([p=0.046, r=0.216]; [p=0.039, r=0.223]; [p=0.011, r=0.273]). The results found that high physical activity improves mental health and cognition. This study suggested that physical activity can alleviate symptoms of depression and anxiety among medical students.
Clinical characteristics of maxillofacial fracture patients in Dr. M. Djamil General Hospital Padang Hafiz, Al; Maidatuz Zahra, Agnesia; Mulyani, Henny; Huriyati, Effy; Revilla, Gusti; Zhuhra, Rahma Tsania
Oto Rhino Laryngologica Indonesiana Vol. 54 No. 2 (2024): VOLUME 54, NO. 2 JULY - DECEMBER 2024
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v54i2.661

Abstract

Background: Maxillofacial fracture consists of several types of fractures depending on their location. Traffic accidents are the most common cause of these cases. The choice of management given in maxillofacial fractures is divided into immediate and planned delayed management, depending on the condition of the injured tissue. Purpose: To describe the clinical characteristics of maxillofacial fracture in the Department of Otorhinolaryngology Faculty of Medicine Universitas Andalas/Dr. M. Djamil General Hospital Padang, in 2020 to 2022. Method: A descriptive study with retrospective approach. The study was conducted by collecting data from the medical record section by using a total sampling technique (59 patients) from 2020 to 2022. Result: The highest cause was traffic accidents (49.2%), the most common findings were nasal bone fracture (44.1%), with operative management (82.4%). Conclusion: Maxillofacial fractures were most commonly experienced by the young age group and caused by traffic accidents, therefore driving safety and driver compliance should be more emphasized. Keywords: maxillofacial fracture, ORIF (Open Reduction Internal Fixation), septorhinoplasty, septoplasty, rhinoplasty ABSTRAK Latar belakang: Fraktur maksilofasial terdiri dari beberapa jenis fraktur tergantung lokasinya. Kecelakaan lalu lintas menjadi penyebab tersering dari kasus ini. Pemilihan tatalaksana yang diberikan pada fraktur maksilofasial dibagi menjadi tatalaksana segera dan tatalaksana lanjutan terencana, tergantung dari kondisi jaringan yang terluka. Tujuan: Untuk mengetahui karakteristik klinis pasien fraktur maksilofasial di Departemen THT-BKL FK Unand/RSUP Dr. M. Djamil Padang, dari 2020 sampai 2022. Metode: Penelitian ini bersifat deskriptif dengan pendekatan retrospektif. Penelitian dilakukan dengan pengambilan data di bagian rekam medik dengan teknik total sampling dan didapatkan sampel sebanyak 59 pasien pada tahun 2020 sampai 2022. Hasil: kelompok usia paling sering adalah 16-30 tahun (54.2%), dengan jenis kelamin terbanyak adalah laki-laki (76.3%), penyebab tersering adalah kecelakaan lalu lintas (4.2%), jenis fraktur tersering adalah fraktur tulang hidung (44.1%), dan tatalaksana paling sering adalah tatalaksana operatif (82.4%) Kesimpulan: Fraktur maksilofasial paling sering dialami oleh kelompok usia remaja dan disebabkan kecelakaan lalu lintas, oleh karena itu keselamatan dan kepatuhan berkendara perlu lebih diperhatikan dan ditingkatkan. Kata kunci: fraktur maksilofasial, ORIF (Open Reduction Internal Fixation), septorinoplasti, septoplasti, rinoplasti
Programmed Death-Ligand 1 (PD-L1) and Ki-67 Labeling Index: Correlation with Tumor Grade and Recurrence Wildanur, Sri; Yenita; Mulyani, Henny
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 1 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i1.1165

Abstract

Background: Meningiomas are common primary brain tumors with variable clinical behavior. While most are benign, a subset exhibits aggressive characteristics and a high recurrence rate. This study aimed to investigate the association of Programmed Death-Ligand 1 (PD-L1) and Ki-67 labeling index with histopathological grade and recurrence in meningioma. Methods: A retrospective study was conducted on 139 cases of meningioma diagnosed between January 2020 and December 2023. PD-L1 expression was evaluated using immunohistochemistry (IHC) and scored using the combined positive score (CPS). Ki-67 labeling index was determined as the percentage of tumor cells with positive nuclear staining. The association of PD-L1 and Ki-67 with histopathological grade and recurrence was analyzed. Results: PD-L1 expression was positive in 66.7% of cases and was significantly associated with recurrence (p = 0.006). A higher Ki-67 labeling index (>4%) was observed in 68.9% of cases and was also significantly associated with recurrence (p = 0.013). No significant association was found between PD-L1 expression or Ki-67 labeling index and histopathological grade. Conclusion: PD-L1 expression and Ki-67 labeling index may serve as potential prognostic markers for predicting recurrence in meningioma. Further studies are needed to validate these findings and explore their potential therapeutic implications.
Challenges in diagnosing schwannoma mimicking thyroid neoplasms on frozen section Ramadhani, Rahmi; Mayorita, Pamelia; Asri, Aswiyanti; Mulyani, Henny; Novianti, Hera
Science Midwifery Vol 13 No 2 (2025): June: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i2.1977

Abstract

Schwannoma is a benign soft tissue tumor of the nerve sheath, composed of neoplastic cells with Schwann cell differentiation. It predominantly arises from peripheral nerves in the head, neck, and extremities, with a peak incidence in the fourth to sixth decades. Schwannoma is typically a solitary and sporadic lesion, affecting individuals of all ages, with an incidence rate of 4.4-5.23 cases per 100,000 people. The prevalence is around 7% of all primary nervous system tumors, often occurring in the head and neck (20-50%) and affecting cranial nerves such as N. Vagus and N. Sympathetic. This case report involves a 50-year-old female patient presenting with a right neck lump that had been present for 23 years, initially small but growing rapidly in the last 10 years with occasional pain. Initial imaging suggested a thyroid complex cyst, but further investigation, including a CT scan and intraoperative frozen section examination, raised suspicion for a malignant thyroid tumor. However, histopathological analysis confirmed the diagnosis of Schwannoma, distinguishing it from other potential malignant lesions, such as Anaplastic Thyroid Carcinoma (ATC). This case highlights the importance of intraoperative cytology and frozen section techniques for diagnosing Schwannoma. Although Schwannomas share morphological similarities with other tumors, particularly in the thyroid region, a multidisciplinary approach combining clinical, radiological, and histopathological findings is essential for an accurate diagnosis. This case also underscores the need for careful differential diagnosis in nerve sheath tumors located in the neck.
Analisis Karakteristik Klinikopatologi Kanker Kolorektal di Laboratorium Patologi Anatomi RSUP Dr. M. Djamil 2020-2022 Aden, Kuntum Annisa Tiara; Mulyani, Henny; Suchitra, Avit; Hilbertina, Noza; Nurhayati, Nurhayati
Jurnal Penelitian Sains Vol 27, No 1 (2025)
Publisher : Faculty of Mathtmatics and Natural Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56064/jps.v27i1.1181

Abstract

 Kanker kolorektal adalah kanker yang tumbuh di kolon (usus besar) dengan kejadian yang terus meningkat setiap tahun. Faktor yang menentukan prognosis kanker kolorektal adalah usia, jenis kelamin, jenis keganasan, topografi, dan histopatologi. Penelitian ini bertujuan untuk mengenali jenis – jenis kanker kolorketal dan bagaimana karakteristik klinikopatologinya di Laboratorium Patologi Anatomi RSUP Dr. M. Djamil Padang tahun 2020 - 2022. Penelitian dilakukan dengan metode deskriptif observasional dengan teknik total sampling dari rekam medis. Kriteria inklusi sampel adalah seluruh pasien kanker kolorektal yang menjalani reseksi tahun 2020 - 2022 dengan diagnosis pertama kali dengan jumlah sampel 196 sampel. Hasil penelitian menunjukkan bahwa kanker kolorektal paling banyak terjadi pada pasien pada usia lebih dari 50 tahun (63,3%), jenis kelamin perempuan (51%), dan lokasi kanker kolorektal yang paling banyak dijumpai di rektum (44,9%), dengan ukuran tumor berkisar dari 4 sampai 6 cm (34,7%). Jenis keganasan yang paling sering ditemukan adalah Adenocarcinoma NOS di rektum. Kesimpulan penelitian ini adalah bahwa dalam rentang tahun 2020 – 2022, insiden kanker kolorektal terbanyak di Laboratorium Patologi Anatomi RSUP Dr. M. Djamil Padang adalah perempuan usia di atas 50 tahun dengan jenis keganasan berupa Adenocarcinoma NOS di rektum.
And, The, Of, In SOX10 and The Tendency of Perineural Invasion in Salivary Gland Adenoid Cystic Carcinoma: SOX10 and The Tendency of Perineural Invasion Safnita, Dewi; Hilbertina, Noza; Mulyani, Henny; Tofrizal; Khambri, Daan; Yetti, Husna
Majalah Patologi Indonesia Vol. 34 No. 3 (2025): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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Abstract

ABSTRACT Background Adenoid cystic carcinoma is a malignant salivary gland tumor with unique features, including slow growth, progressive, poor prognosis, recurrence propensity, and perineural invasion tendency. SOX10 is a transcription factor expressed in the majority of tumors. SOX10 overexpression was hypothesized to play an important role in tumor-stroma interactions, especially perineural invasion and histopathological patterns. Method A cross-sectional study was performed using 30 blocks of formalin-fixed embedded specimens previously diagnosed as salivary gland adenoid cystic carcinomas. Perineural invasion and histopathological patterns were evaluated followed by immunohistochemical staining to evaluate SOX10 expression. The staining intensity and proportion of positively stained cells in both tumor and stroma cells were grouped into high and low expression levels. Chi-square tests were used for statistical analysis. Result The cribriform pattern was the most common histopathological pattern in both high and low SOX10 expression. The majority of tumors with high SOX10 expression (66.67% in stroma cells and 73.33% in tumor cells) were found to have more perineural invasion. Conclusion There was a tendency for perineural invasion in tumors with high SOX10 expression, although this was not statistically significant. There was no significant association between SOX10 expression and histopathological pattern.
Co-Authors Aden, Kuntum Annisa Tiara Al Hafiz Aswiyanti Asri Daan Khambri Effy Huriyati Gusti Revilla Husna Yetti Indradmojo, Christyaji Mahendra, Muhammad Isa Maidatuz Zahra, Agnesia Mayorita, Pamelia Novianti, Hera Noza Hilbertina, Noza Nur, Aswaty Nurhayati Nurhayati Rahmi Ramadhani Rastramadhani, Faresa Aulia Rindradi, Ridha Saniyyah Riskawati, Yhusi Karina Safnita, Dewi Suchitra, Avit Tofrizal Wildanur, Sri Yenita . Zhuhra, Rahma Tsania