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Hanafi, Eka Satria Akbar Ferdinan
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Effects of Kratom (Mitragyna speciosa) Hydrogel Application on Pancreatic Histopathology in Type 2 Diabetic Mice Muhammad Aqil Siroj Jazuli; Ismail, Zainul Hadi Wildan; Rihhadatulays, Khuzaimah Nur Juhanifah; Hanafi, Eka Satria Akbar Ferdinan; Jinan, Puspita Rahmatul; Pramesti, Rosandhy Alifyah; Salim, Hotimah Masdan; Bintarti, Tri Wahyuni
Jurnal Ilmu Kesehatan dan Kesehatan Vol 9 No 2 (2025): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v9i2.8018

Abstract

Background: Type 2 diabetes mellitus is a metabolic disorder characterized by elevated blood glucose caused by insulin resistance and impaired insulin production by pancreatic β-cells due to oxidative stress. Kratom (Mitragyna speciosa) has been widely investigated for its antidiabetic, anti-inflammatory, and antioxidant effects, attributed to its alkaloid, flavonoid, phenolic, and saponin contents. This study aimed to evaluate the potential of topical kratom hydrogel as an innovative approach to improving pancreatic histology in type 2 diabetic mice, which has not been previously reported. Methods: Fifteen mice were divided into three groups: untreated diabetic group (DM), diabetic group treated with 5% kratom hydrogel (K5), and diabetic group treated with 15% kratom hydrogel (K15). Treatments were administered for two weeks. Parameters assessed included the percentage of healthy β-cells and acinar cells, as well as histological scoring of islet damage. Data were analyzed using parametric or non-parametric tests according to the normality distribution of each parameter. Results: Administration of 5% kratom hydrogel significantly increased the percentage of healthy β-cells (p<0.05) compared with 15% kratom hydrogel, which unexpectedly showed a lower proportion of healthy cells than the untreated group. Interestingly, the higher dose appeared to exert more toxic effects, whereas the lower dose provided better protective effects. No significant differences were observed in acinar cell parameters or islet damage scores, possibly due to the limited sample size. Conclusion: These findings provide preliminary evidence supporting the systemic therapeutic potential of topical kratom hydrogel, particularly in determining the effective dose and the need for larger sample sizes to obtain more consistent outcomes.
Effect of Kratom (Mitragyna speciosa) Hydrogel on Liver Function in Diabetic Burn Injury Pramesti, Rosandhy Alifyah Pramesti; Jazuli, Muhammad Aqil Siroj; Ismail, Zainul Hadi Wildan; Rihhadatulays, Khuzaimah Nur Juhanifah; Hanafi, Eka Satria Akbar Ferdinan; Jinan, Puspita Rahmatul; Salim, Hotimah Masdan; Bermawi, Bastiana
Jurnal Medis Islam Internasional Vol 7 No 2 (2025): December
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v7i2.8239

Abstract

Introduction: Burns are serious injuries that not only damage the skin but can also affect internal organs such as the liver. Severe inflammation following burn injury increases hepatocyte vulnerability, especially in diabetic conditions. Objective: This study aimed to evaluate the effect of topical kratom (Mitragyna speciosa) hydrogel on liver histopathology in streptozotocin-induced diabetic mice with burn injuries. Methods: An in vivo experimental study with a post-test-only control group design was conducted using 15 male musmusculus. Diabetes mellitus was induced prior to burn injury, and hyperglycemia was confirmed before further procedures. The diabetic mice were then randomly assigned into three groups: diabetic burn injury without hydrogel treatment (K), diabetic burn injury treated with 5% kratom hydrogel (T1), and diabetic burn injury treated with 15% kratom hydrogel (T2). The respective treatments were applied for four weeks. Following the intervention period, liver tissues were collected for histopathological analysis. Hepatocyte damage was quantitatively assessed and analyzed using one-way ANOVA followed by Dunnett’s post hoc test. Results: The diabetic burn injury control group exhibited the greatest extent of hepatocyte damage (66.5 ± 5.0%). Application of 5% kratom hydrogel (49.5 ± 4.0%) and 15% kratom hydrogel (52.5 ± 4.0%) resulted in a statistically significant reduction in hepatocyte injury compared with the diabetic control group (p = 0.0043 and p = 0.0131, respectively). Conclusions: Topical administration of kratom hydrogel significantly attenuated hepatocyte damage in diabetic mice subjected to burn injuries, suggesting a hepatoprotective effect and potential benefits for preserving liver function under diabetic burn conditions.
Efektivitas Penggunaan Hidrogel Kratom Terhadap Kadar Gula Darah Pada Ulkus Diabetikum Rihhadatulays, Khuzaimah Nur Juhanifah; Pramesti, Rosandhy Alifyah; Hanafi, Eka Satria Akbar Ferdinan; Jazuli, Muhammad Aqil Siroj; Salim, Hotimah Masdan; Amani, Fariska Zata; Aisyah, Aisyah
Bahasa Indonesia Vol 6 No 2 (2025): Prominentia Medical Journal
Publisher : Universitas Ciputra Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37715/pmj.v6i2.6076

Abstract

Type 2 diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia resulting from insulin resistance and pancreatic β-cell dysfunction. One of the most common complications is diabetic ulcers, which are often associated with vascular impairment, infection, and poor glucose stability. The search for alternative therapies continues to develop, including the use of Mitragyna speciosa (kratom) leaves, which contain mitragynine and flavonoids that have been shown to inhibit α-glucosidase and enhance antioxidant activity. This study aimed to evaluate the effect of kratom hydrogel on blood glucose levels in an animal model of diabetic ulcers. Using a posttest-only control group design, mice (Mus musculus) were induced with streptozotocin to establish a type 2 diabetes model. The animals were divided into three groups: positive control, 5% kratom hydrogel, and 15% kratom hydrogel. Blood glucose levels were measured weekly over a two-week period. Data were analyzed using the Kruskal–Wallis test followed by Dunn’s multiple comparison test. The results showed differences in blood glucose levels among all treatment groups. The 15% kratom hydrogel group demonstrated a significant reduction in blood glucose, approaching near-normal levels compared with the positive control (p < 0.05). Statistical analysis indicated a more dominant effect compared to the variation of treatment types. These findings suggest a synergistic mechanism through α-glucosidase inhibition and enhanced antioxidant activity. Therefore, kratom hydrogel has potential as a complementary therapy for glycemic control in patients with type 2 diabetes mellitus complicated by diabetic ulcers.
Co-Authors Aisyah Aisyah Bermawi, Bastiana Bintarti, Tri Wahyuni Fariska Zata Amani Ismail, Zainul Hadi Wildan Jazuli, Muhammad Aqil Siroj Jinan, Puspita Rahmatul Muhammad Aqil Siroj Jazuli Pramesti, Rosandhy Alifyah Pramesti, Rosandhy Alifyah Pramesti Rihhadatulays, Khuzaimah Nur Juhanifah Salim, Hotimah Masdan