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All Journal Medical and Health Science Journal Community Development Journal: Jurnal Pengabdian Masyarakat International Islamic Medical Journal Prominentia Medical Journal
Rihhadatulays, Khuzaimah Nur Juhanifah
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Religion Humanities Dentistry Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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The Role Of Mitragyna speciosa (Korth) As An Anti-Inflammatory Agent In Wound Healing In Living Cells Ferdinan Hanafi, Eka Satria Akbar; Pramesti, Rosandhy Alfiyah; Jazuli, Muhammad Aqil Siroj; Rihhadatulays, Khuzaimah Nur Juhanifah; Salim, Hotimah Masdan; Savitri, Ardyarini Dyah
Jurnal Ilmu Kesehatan dan Kesehatan Vol 9 No 1 (2025): FEBRUARY : Fragmentation In Modern Healthcare Approaches Amid Rising Chronic And
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v9i1.7994

Abstract

Background: Wound is a condition in which the integrity of body tissue is disrupted, leading to the activation of a complex biological process known as wound healing. This process aims to restore the protective skin barrier, prevent infection, and minimize fluid loss. It involves sequential phases of hemostasis, inflammation, proliferation, and remodeling. While inflammation is essential for initiating repair, prolonged or excessive inflammation may delay the healing process. Mitragyna speciosa (Korth) is a medicinal plant traditionally used in various cultures and has been reported to exhibit multiple pharmacological properties, including anti-inflammatory, antioxidant, antibacterial, analgesic, and wound-healing activities. Methods: The present systematic review was conducted to identify and synthesize scientific evidence regarding the potential of Mitragyna speciosa extract as a therapeutic agent in wound healing through anti-inflammatory and other biological pathways. Literature searches were performed in ScienceDirect, PubMed, MDPI, DOAJ, and Google Scholar following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results :A total of 1,176 studies were screened, and five experimental studies fulfilled the inclusion criteria. The findings consistently demonstrated that Mitragyna speciosa extract suppressed pro-inflammatory mediators such as nitric oxide, reactive oxygen species, tumor necrosis factor-alpha, interleukin-6, and enzymatic pathways including cyclooxygenase-2 and 5-lipoxygenase. In addition, the extract stimulated cell migration, endothelial migration, and angiogenesis, thereby supporting tissue regeneration. Toxicity profiles suggest that the extract is safe at effective concentrations, although responses remain dose-dependent. Conclusions: Overall, Mitragyna speciosa shows promise as a plant-based therapeutic option for wound healing. Nevertheless, current evidence is limited and largely derived from in vitro studies, indicating the need for more extensive in vivo and clinical investigations.
Effects of Kratom (Mitragyna speciosa) Hydrogel Application on Pancreatic Histopathology in Type 2 Diabetic Mice Muhammad Aqil Siroj Jazuli; Ismail, Zainul Hadi Wildan; Rihhadatulays, Khuzaimah Nur Juhanifah; Hanafi, Eka Satria Akbar Ferdinan; Jinan, Puspita Rahmatul; Pramesti, Rosandhy Alifyah; Salim, Hotimah Masdan; Bintarti, Tri Wahyuni
Jurnal Ilmu Kesehatan dan Kesehatan Vol 9 No 2 (2025): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v9i2.8018

Abstract

Background: Type 2 diabetes mellitus is a metabolic disorder characterized by elevated blood glucose caused by insulin resistance and impaired insulin production by pancreatic β-cells due to oxidative stress. Kratom (Mitragyna speciosa) has been widely investigated for its antidiabetic, anti-inflammatory, and antioxidant effects, attributed to its alkaloid, flavonoid, phenolic, and saponin contents. This study aimed to evaluate the potential of topical kratom hydrogel as an innovative approach to improving pancreatic histology in type 2 diabetic mice, which has not been previously reported. Methods: Fifteen mice were divided into three groups: untreated diabetic group (DM), diabetic group treated with 5% kratom hydrogel (K5), and diabetic group treated with 15% kratom hydrogel (K15). Treatments were administered for two weeks. Parameters assessed included the percentage of healthy β-cells and acinar cells, as well as histological scoring of islet damage. Data were analyzed using parametric or non-parametric tests according to the normality distribution of each parameter. Results: Administration of 5% kratom hydrogel significantly increased the percentage of healthy β-cells (p<0.05) compared with 15% kratom hydrogel, which unexpectedly showed a lower proportion of healthy cells than the untreated group. Interestingly, the higher dose appeared to exert more toxic effects, whereas the lower dose provided better protective effects. No significant differences were observed in acinar cell parameters or islet damage scores, possibly due to the limited sample size. Conclusion: These findings provide preliminary evidence supporting the systemic therapeutic potential of topical kratom hydrogel, particularly in determining the effective dose and the need for larger sample sizes to obtain more consistent outcomes.
INISIASI PROGRAM REHABILITASI PSIKOSOSIAL BERBASIS RUMAH SAKIT UNTUK ORANG DENGAN GANGGUAN JIWA DAN ANAK BERKEBUTUHAN KHUSUS DI SURABAYA Algristian, Hafid; Delina, Lini; Fitriyah, Fifi Khoirul; Khamida, Khamida; S, Nur Azizah A.; Brylyani, Diyani Shafira; Chambali, Zafira Aliya Shafwa Putri; Rihhadatulays, Khuzaimah Nur Juhanifah; Bariyah, Khadijah Khairul
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 5 No. 6 (2024): Vol. 5 No. 6 Tahun 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v5i6.38790

Abstract

Orang dengan gangguan jiwa dan anak berkebutuhan khusus (ABK) membutuhkan perhatian khusus dalam penanganan psikososial. Keterbatasan fasilitas dan layanan khusus di rumah sakit mendorong perlunya inisiasi program rehabilitasi berbasis rumah sakit khususnya di Surabaya. Program ini bertujuan untuk memperkenalkan terapi perilaku sebagai bagian dari layanan untuk ABK dan gangguan jiwa di RSI Surabaya Jemursari—yang mana di tahun ini akan dimulai berfokus pada peyuluhan Terapi Perilaku untuk ABK. Program ini bertujuan untuk memulai kerjasama antara lembaga kesehatan dan komunitas dalam menyediakan layanan terapi perilaku bagi ABK, serta merekrut pasien melalui promosi sosial media dan webinar. Tahapan pelaksanaan dimulai dengan FGD antar tim pelaksana dan mitra seperti RSI Surabaya Jemursari. Dilanjutkan dengan penyuluhan terapi perilaku yang melibatkan masyarakat awam, guru, dan tenaga kesehatan. Seminar daring diadakan dengan Yayasan Peduli Kasih ABK dan AMSA UNAIR untuk audiensi masyarakat, dan seminar bagi tenaga kesehatan di RSI Jemursari untuk mengenalkan layanan terapi perilaku untuk ABK. Penyuluhan dan seminar berhasil diadakan, melibatkan berbagai pihak untuk mendukung program ini. Rekrutmen tenaga kesehatan seperti psikolog klinis dan terapis perilaku telah dimulai. Upaya untuk merekrut pasien dilakukan melalui promosi di media sosial dan webinar. Sehingga disimpulkan inisiasi program telah berjalan dengan baik. Keberlanjutan program inisiasi Terapi Perilaku untuk ABK akan difokuskan pada promosi di komunitas dan sekolah, serta standardisasi layanan melalui pembuatan SOP, pelatihan, dan sertifikasi terapis perilaku.
Effect of Kratom (Mitragyna speciosa) Hydrogel on Liver Function in Diabetic Burn Injury Pramesti, Rosandhy Alifyah Pramesti; Jazuli, Muhammad Aqil Siroj; Ismail, Zainul Hadi Wildan; Rihhadatulays, Khuzaimah Nur Juhanifah; Hanafi, Eka Satria Akbar Ferdinan; Jinan, Puspita Rahmatul; Salim, Hotimah Masdan; Bermawi, Bastiana
Jurnal Medis Islam Internasional Vol 7 No 2 (2025): December
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v7i2.8239

Abstract

Introduction: Burns are serious injuries that not only damage the skin but can also affect internal organs such as the liver. Severe inflammation following burn injury increases hepatocyte vulnerability, especially in diabetic conditions. Objective: This study aimed to evaluate the effect of topical kratom (Mitragyna speciosa) hydrogel on liver histopathology in streptozotocin-induced diabetic mice with burn injuries. Methods: An in vivo experimental study with a post-test-only control group design was conducted using 15 male musmusculus. Diabetes mellitus was induced prior to burn injury, and hyperglycemia was confirmed before further procedures. The diabetic mice were then randomly assigned into three groups: diabetic burn injury without hydrogel treatment (K), diabetic burn injury treated with 5% kratom hydrogel (T1), and diabetic burn injury treated with 15% kratom hydrogel (T2). The respective treatments were applied for four weeks. Following the intervention period, liver tissues were collected for histopathological analysis. Hepatocyte damage was quantitatively assessed and analyzed using one-way ANOVA followed by Dunnett’s post hoc test. Results: The diabetic burn injury control group exhibited the greatest extent of hepatocyte damage (66.5 ± 5.0%). Application of 5% kratom hydrogel (49.5 ± 4.0%) and 15% kratom hydrogel (52.5 ± 4.0%) resulted in a statistically significant reduction in hepatocyte injury compared with the diabetic control group (p = 0.0043 and p = 0.0131, respectively). Conclusions: Topical administration of kratom hydrogel significantly attenuated hepatocyte damage in diabetic mice subjected to burn injuries, suggesting a hepatoprotective effect and potential benefits for preserving liver function under diabetic burn conditions.
Efektivitas Penggunaan Hidrogel Kratom Terhadap Kadar Gula Darah Pada Ulkus Diabetikum Rihhadatulays, Khuzaimah Nur Juhanifah; Pramesti, Rosandhy Alifyah; Hanafi, Eka Satria Akbar Ferdinan; Jazuli, Muhammad Aqil Siroj; Salim, Hotimah Masdan; Amani, Fariska Zata; Aisyah, Aisyah
Bahasa Indonesia Vol 6 No 2 (2025): Prominentia Medical Journal
Publisher : Universitas Ciputra Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37715/pmj.v6i2.6076

Abstract

Type 2 diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia resulting from insulin resistance and pancreatic β-cell dysfunction. One of the most common complications is diabetic ulcers, which are often associated with vascular impairment, infection, and poor glucose stability. The search for alternative therapies continues to develop, including the use of Mitragyna speciosa (kratom) leaves, which contain mitragynine and flavonoids that have been shown to inhibit α-glucosidase and enhance antioxidant activity. This study aimed to evaluate the effect of kratom hydrogel on blood glucose levels in an animal model of diabetic ulcers. Using a posttest-only control group design, mice (Mus musculus) were induced with streptozotocin to establish a type 2 diabetes model. The animals were divided into three groups: positive control, 5% kratom hydrogel, and 15% kratom hydrogel. Blood glucose levels were measured weekly over a two-week period. Data were analyzed using the Kruskal–Wallis test followed by Dunn’s multiple comparison test. The results showed differences in blood glucose levels among all treatment groups. The 15% kratom hydrogel group demonstrated a significant reduction in blood glucose, approaching near-normal levels compared with the positive control (p < 0.05). Statistical analysis indicated a more dominant effect compared to the variation of treatment types. These findings suggest a synergistic mechanism through α-glucosidase inhibition and enhanced antioxidant activity. Therefore, kratom hydrogel has potential as a complementary therapy for glycemic control in patients with type 2 diabetes mellitus complicated by diabetic ulcers.
Co-Authors Aisyah Aisyah Algristian, Hafid Bariyah, Khadijah Khairul Bermawi, Bastiana Bintarti, Tri Wahyuni Brylyani, Diyani Shafira Chambali, Zafira Aliya Shafwa Putri Delina, Lini Fariska Zata Amani Ferdinan Hanafi, Eka Satria Akbar Fifi Khoirul Fitriyah Hanafi, Eka Satria Akbar Ferdinan Ismail, Zainul Hadi Wildan Jazuli, Muhammad Aqil Siroj Jinan, Puspita Rahmatul Khamida, Khamida Muhammad Aqil Siroj Jazuli Pramesti, Rosandhy Alfiyah Pramesti, Rosandhy Alifyah Pramesti, Rosandhy Alifyah Pramesti S, Nur Azizah A. Salim, Hotimah Masdan Savitri, Ardyarini Dyah