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All Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY
Ulhaq, Renata Alya
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Health Professions Medicine & Pharmacology Public Health Social Sciences

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The Antibiotic Prescribing Practices of Gynecologists in Abdominal Hysterectomy Tjokroprawiro, Brahmana Askandar; Khoirunnisa Novitasari; Ulhaq, Renata Alya; Aldika Akbar, Muhammad Ilham
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 3 Jully 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i3.1954

Abstract

Objective: To evaluate the pattern of antibiotics used for abdominal hysterectomy by gynecologists in infected and non-infected cases. Methods: Data was collected through an online survey of gynecologists in Surabaya, Indonesia. Results: A total of 200 gynecologists were involved in this study. All of them used prophylactic antibiotics in all cases of abdominal hysterectomy, and the most commonly used was cefazoline (70.5%), followed by ceftriaxone (15.5%) and cefotaxime (9%). Most gynecologists (68%) gave 2 grams of prophylactic antibiotic, and 79,5% of antibiotics were administered within 30 minutes before surgery. Additional antibiotics during surgery were given in prolonged surgery (79.01%) and intraoperative bleeding > 1500 mL (48.14%). The most common additional dosage used was 1 gram (72.9%), and most gynecologists (37.2%) continued antibiotics for one day ahead. The type of therapeutic antibiotics used for infected cases was varied, consisting of ceftriaxone (50.5%), metronidazole (42%), cefotaxime (17%), cefazoline (15.5%), gentamicin (12%), ampicillin-sulbactam (4%), and amoxicillin-clavulanic acid (3.5%). Most gynecologists (43.7%) gave these antibiotics for three days. Conclusion: The majority of gynecologists in Surabaya already use prophylactic antibiotics for abdominal hysterectomy and therapeutic antibiotics for infected cases following the existing guidelines
Effect of Bay Leaf (Syzygium polyanthum) Extract on Antioxidant Activity, MDA Levels, and Liver Histopathology Feature of Ethambutol Induced Wistar Rats Suwito, Bambang Edi; Shanty, Lea Maera; Gumilang, Retna; Handayani, Handayani; Ulhaq, Renata Alya
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 4 No 2 (2022): Enhanced knowledge of laboratory medicine's role in healthcare
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v4i2.2471

Abstract

Bay leaf extract (Syzygiun polianthum) is one herbal elemnt that may be used to lessen liver function issues, lessen symptops of nausea, vomiting, discomfort and improve adherence and the effectiveness of tuberculossi treatment. The objective of this study was to determine the effect of bay leaf (Syzygium polyanthum) extract on antioxidant activity, Malondialdehyde (MDA) levels, and liver histopathology of ethambutol-induced Wistar rats. This research is a laboratory experiment. Antioxidant activity of Bay Leaf Extract was evaluated by comparing vitamin C with spectrophotometry methods. White Wistar rats were separated into 6 groups and uset to test the lebel of MDA and livers histopathology. Group 1 serves as the control group and received DMSO (placebo); Group 2 was received ethambutol 50mg/kg BW; Group 3 was received ethambutol and silymarine with dose 50mh/kg BW. Group 4-6 had been given ethambutol and extra ethanol extract of bay leaves of 75,150, dan 300mg/kg BW, respectively. The results of the spectrophotometry showed that the Bay Leaf Extract had antioxidant activity comparable to that of vitamin C, with an IC50 of 11.4 g ± (4.4%). One-Way ANOVA test results obtained p = 0.002 (p<0.05) while the Kruskal-Wallis test results obtained the Asymp. Sig value 0.105> 0.05. There was a significance difference in each group’s MDA levels (p=0.002). Although there was no significant difference in the liver histopathology of treated rats (p>0.05). While bay leaf extract significantly lowers MDA levels in ethambutol-induced Wistar rats, it has no discernible impact on the liver histopathology of ethambutol-induced Wistar rats. Bay leaf extract possesses antioxidant activity comparable to vitamin C.
Co-Authors Aldika Akbar, Muhammad Ilham Askandar Tjokroprawiro Bambang Edi Suwito Gumilang, Retna Handayani Handayani Khoirunnisa Novitasari Shanty, Lea Maera