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Daimah Wirdatus Sanaun Harahap
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Health Professions Public Health

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Uji Aktivitas Antioksidan Ekstrak Etanol Herba Sirih Cina (Peperomia pellucida L.) dengan Metode DPPH Jecika Stefany Br Tumanggor; Razoki Razoki; Muhammad Yunus; Daimah Wirdatus Sanaun Harahap
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 2 (2025): Juli: Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i2.6142

Abstract

Free radicals are reactive compounds that can cause damage to cells, enzymes, lipids, and even DNA, thus triggering various degenerative diseases. Antioxidants neutralize free radicals and prevent oxidative damage. Chinese betel herb (Peperomia pellucida L.) is known to contain phenol and flavonoid secondary metabolite compounds that act as natural antioxidants. This study aims to test the antioxidant activity of ethanol extract of Chinese betel herb with DPPH (2,2-diphenyl-1-picrylhydrazyl) method. Extraction was done by maceration method using 80% ethanol solvent. Antioxidant activity was tested by reacting the extract against DPPH solution and measuring the absorbance using UV-Vis spectrophotometry. The results showed an IC₅₀ value of 32.97 ppm, which is classified as very strong antioxidant activity. These results indicate that ethanol extract of Chinese betel herb has great potential as a source of natural antioxidants.  
Uji Aktivitas Antioksidan Ekstrak Etanol Daun Pepaya (Carica papaya L.) dengan Metode DPPH Anggun Pratiwi; Razoki Razoki; Muhammad Yunus; Daimah Wirdatus Sanaun Harahap
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 2 (2025): Juli: Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i2.6231

Abstract

Oxidative stress is a condition resulting from an imbalance between free radicals and the body's antioxidant system, which can damage cells and trigger degenerative diseases such as diabetes, cancer, atherosclerosis and heart disease. Antioxidants play an important role in neutralizing free radicals to prevent cell damage. Papaya leaves (Carica papaya L.) are known to contain bioactive compounds that have potential as a source of natural antioxidants. This study aims to test the antioxidant activity of papaya leaf ethanol extract using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method, with quercetin as a comparator. Extraction was done by maceration using 80% ethanol. Antioxidant activity was measured based on the decrease in absorbance of DPPH solution at a wavelength of 517 nm using UV-Vis spectrophotometer. The results showed that papaya leaf extract had strong antioxidant activity with IC₅₀ value of 21.35 ppm, while quercetin was 4.84 ppm. Thus, the ethanol extract of papaya leaves showed high potential as an effective natural antioxidant.  
Co-Authors Anggun Pratiwi Jecika Stefany Br Tumanggor Muhammad Yunus Razoki Razoki