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All Journal Jurnal Kesehatan dan Kedokteran Jurnal Penelitian Sains dan Kesehatan Avicenna Sinergi : Jurnal Ilmiah Multidisiplin Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Daimah Wirdatus Sanaun Harahap
Unknown Affiliation
Aerospace Engineering Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Nursing Physics Public Health Social Sciences

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Uji Aktivitas Antioksidan Ekstrak Etanol Herba Sirih Cina (Peperomia pellucida L.) dengan Metode DPPH Jecika Stefany Br Tumanggor; Razoki Razoki; Muhammad Yunus; Daimah Wirdatus Sanaun Harahap
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 2 (2025): Juli: Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i2.6142

Abstract

Free radicals are reactive compounds that can cause damage to cells, enzymes, lipids, and even DNA, thus triggering various degenerative diseases. Antioxidants neutralize free radicals and prevent oxidative damage. Chinese betel herb (Peperomia pellucida L.) is known to contain phenol and flavonoid secondary metabolite compounds that act as natural antioxidants. This study aims to test the antioxidant activity of ethanol extract of Chinese betel herb with DPPH (2,2-diphenyl-1-picrylhydrazyl) method. Extraction was done by maceration method using 80% ethanol solvent. Antioxidant activity was tested by reacting the extract against DPPH solution and measuring the absorbance using UV-Vis spectrophotometry. The results showed an IC₅₀ value of 32.97 ppm, which is classified as very strong antioxidant activity. These results indicate that ethanol extract of Chinese betel herb has great potential as a source of natural antioxidants.  
Uji Aktivitas Antioksidan Ekstrak Etanol Daun Pepaya (Carica papaya L.) dengan Metode DPPH Anggun Pratiwi; Razoki Razoki; Muhammad Yunus; Daimah Wirdatus Sanaun Harahap
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 2 (2025): Juli: Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i2.6231

Abstract

Oxidative stress is a condition resulting from an imbalance between free radicals and the body's antioxidant system, which can damage cells and trigger degenerative diseases such as diabetes, cancer, atherosclerosis and heart disease. Antioxidants play an important role in neutralizing free radicals to prevent cell damage. Papaya leaves (Carica papaya L.) are known to contain bioactive compounds that have potential as a source of natural antioxidants. This study aims to test the antioxidant activity of papaya leaf ethanol extract using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method, with quercetin as a comparator. Extraction was done by maceration using 80% ethanol. Antioxidant activity was measured based on the decrease in absorbance of DPPH solution at a wavelength of 517 nm using UV-Vis spectrophotometer. The results showed that papaya leaf extract had strong antioxidant activity with IC₅₀ value of 21.35 ppm, while quercetin was 4.84 ppm. Thus, the ethanol extract of papaya leaves showed high potential as an effective natural antioxidant.  
Antidiabetic Effectiveness of Ethanol Extract from Sweet Mango Leaves (Mangifera indica L. var. Arum Manis) on Blood Glucose Levels in Streptozotocin-Induced Male Mice (Mus musculus L.) Marisha, Rara Widiya; Astriani Natalia Br Ginting; Daimah Wirdatus Sanaun Harahap
Jurnal Kesehatan dan Kedokteran Vol. 5 No. 1 (2026): Februari: Jurnal Kesehatan dan Kedokteran
Publisher : Asosiasi Dosen Muda Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56127/jukeke.v5i1.2467

Abstract

Diabetes mellitus (DM) is a growing public health concern worldwide, particularly in Indonesia, where its prevalence continues to rise, causing significant health and economic burdens. The need for effective, accessible, and safe therapies is critical, as current treatments often come with side effects and limitations. Alternative natural treatments, such as herbal remedies, are being explored for their potential to offer safer and more sustainable options for managing DM. Objective: This study aims to evaluate the antidiabetic effectiveness of ethanol extract of sweet mango leaves (Mangifera indica L. var. sweet mango) on reducing blood glucose levels in streptozotocin (STZ)-induced diabetic mice. Methodology: A true experimental post-test only control group design was employed using mice (Mus musculus) divided into six groups: normal control, negative control (STZ), positive control (glibenclamide), and three treatment groups of mango leaf extract with doses of 50, 100, and 150 mg/kgBW. The extraction was carried out using the maceration method with 70% ethanol, and the antidiabetic activity was tested over a 15-day period. Results: The results showed that administration of ethanol extract of sweet mango leaves significantly reduced blood glucose levels (p < 0.001) compared to the negative control. A dose-response pattern was observed, with a dose of 150 mg/kgBW providing the most significant blood glucose lowering effect, closely approaching the effectiveness of glibenclamide. Discussion: The antidiabetic activity of the extract is thought to be related to its bioactive compounds, such as flavonoids, phenolics, and mangiferin, which are believed to enhance insulin sensitivity, inhibit gluconeogenesis, and protect pancreatic β cells from oxidative stress. Originality and Contribution: This study provides new insights into the antidiabetic potential of the ethanol extract of sweet mango leaves (Mangifera indica var. Arum Manis), a variety not extensively studied for its effects on diabetes. The research contributes to the growing body of knowledge on natural-based therapies for DM, offering an alternative to conventional treatments with potentially fewer side effects and wider accessibility. The findings support the further development of mango leaf extract as a natural candidate for diabetes management.
Uji Aktivitas Antibakteri Ekstrak Daun Sirsak (Annona muricata L.) terhadap Pseudomonas aeruginosa secara In Vitro Pratiwi, Lulu; Muhammad Yunus; Daimah Wirdatus Sanaun Harahap
Sinergi : Jurnal Ilmiah Multidisiplin Vol. 2 No. 1 (2026): Sinergi: Jurnal Ilmiah Multidisiplin
Publisher : PT. AHLAL PUBLISHER NUSANTARA

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Bacterial infection in chronic wounds, particularly diabetic foot ulcers in patients with diabetes mellitus, remains a serious health problem due to their susceptibility to pathogenic bacteria such as Pseudomonas aeruginosa. Soursop leaves (Annona muricata L.) are rich in bioactive compounds with potential antibacterial properties, and several previous studies have reported their antibacterial activity. Therefore, this study aimed to evaluate the antibacterial activity of soursop leaf extract against these two bacteria in vitro using the disc diffusion method, with inhibition zone diameter as an indicator. This experimental study focused on assessing the interaction of 96% ethanolic soursop leaf extract obtained by maceration against Pseudomonas aeruginosa at various concentrations. The results demonstrated concentration-dependent antibacterial activity, in which increasing extract concentration led to larger inhibition zones. However, the antibacterial effect of the extract was lower than that of the positive control (gentamicin), which may be attributed to the use of crude secondary metabolites and the limitation of the disc diffusion method as a preliminary screening tool with restricted quantitative accuracy. Keywords: soursop leaves (annona muricata L.), antibacterial activity, pseudomonas aeruginosa, disc diffusion method, ethanol extract   Abstrak Infeksi bakteri pada luka kronik, terutama ulkus diabetikum pada penderita diabetes melitus, tetap menjadi masalah kesehatan serius karena kerentanan terhadap bakteri patogen seperti Pseudomonas aeruginosa. Daun sirsak (Annona muricata L.) kaya akan senyawa bioaktif yang berpotensi sebagai antibakteri alami, dan beberapa studi sebelumnya telah menunjukkan aktivitasnya. Oleh karena itu, penelitian ini bertujuan menguji aktivitas antibakteri ekstrak daun sirsak terhadap kedua bakteri tersebut secara in vitro menggunakan metode difusi cakram, dengan mengukur zona hambat sebagai indikator. Penelitian ini bersifat eksperimental, fokus pada pengujian interaksi ekstrak etanol 96% daun sirsak yang diperoleh melalui maserasi terhadap Pseudomonas aeruginosa dengan variasi konsentrasi. Hasilnya menunjukkan aktivitas antibakteri yang bergantung pada konsentrasi, di mana peningkatan konsentrasi ekstrak meningkatkan diameter zona hambat. Namun, daya hambat ekstrak ini masih lebih rendah dibandingkan kontrol positif gentamisin, hal ini dikarenakan ekstrak daun sirsak (Annona Muricata L.) masi merupakan metabolit sekunder, dan metode difusi cakram hanya cocok sebagai skrining awal dengan keterbatasan dalam akurasi. Kata kunci: daun sirsak (annona muricata l.), aktivitas antibakteri, pseudomonas aeruginosa, metode difusi cakram, ekstrak etanol
Evaluasi Penggunaan Obat Diare pada Pasien Balita di Instalasi Rawat Inap Rumah Sakit Royal Prima Tahun 2022 – 2025 panjaitan, gusti nurmawan; Daimah Wirdatus Sanaun Harahap; Astriani Natalia Br Ginting
Jurnal Penelitian Sains dan Kesehatan Avicenna Vol 5 No 2 (2026): Jurnal Penelitian Sains dan Kesehatan Avicenna
Publisher : Lembaga Penelitian Dan Pengabdian Kepada Masyarakat (LPPM), Institut Teknologi Dan Kesehatan (ITK) Avicenna

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69677/avicenna.v5i2.304

Abstract

balita di Indonesia. Evaluasi penggunaan obat secara berkala sangat diperlukan untuk menjamin ketepatan terapi dan mencegah risiko efek samping serta resistensi obat pada pasien pediatrik. Tujuan: Penelitian ini bertujuan untuk mengevaluasi ketepatan penggunaan obat pada pasien balita dengan diare di Instalasi Rawat Inap Rumah Sakit Royal Prima tahun 2022-2025. Metode: Data diambil dari rekam medis pasien balita dengan diagnosa diare yang menjalani rawat inap selama periode 2022–2025. Teknik pengambilan sampel menggunakan purposive sampling. Analisis data dilakukan secara univariat untuk melihat distribusi frekuensi karakteristik pasien dan ketepatan penggunaan obat berdasarkan parameter tepat pasien, tepat indikasi, tepat obat, dan tepat dosis mengacu pada Pedoman Pengendalian Penyakit Diare. Hasil: Hasil penelitian menunjukkan bahwa mayoritas pasien diare balita berjenis kelamin laki-laki, yaitu sebanyak 59%. Sebagian besar pasien berada pada rentang usia 1–5 tahun (76%). Terapi farmakologis yang paling banyak digunakan adalah probiotik (51%) dan zinc (43%). Evaluasi ketepatan penggunaan obat menunjukkan hasil tepat indikasi (100%), tepat obat (100%), tepat pasien (100%), tepat rute pemberian obat (45%), serta ketepatan peresepan berdasarkan panduan Lintas Diare dari Kementerian Kesehatan Republik Indonesia sebesar 100%. Kesimpulan: penggunaan obat diare pada pasien balita di Instalasi Rawat Inap Rumah Sakit Royal Prima tahun 2022-2025 secara umum telah sesuai dengan pedoman pengobatan yang berlaku. Namun, masih diperlukan peningkatan dalam aspek ketepatan rute pemberian obat guna mendukung penerapan penggunaan obat yang lebih rasional dan optimal.
Co-Authors Anggun Pratiwi Astriani Natalia Br Ginting Jecika Stefany Br Tumanggor Marisha, Rara Widiya Muhammad Yunus panjaitan, gusti nurmawan Pratiwi, Lulu Razoki Razoki