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All Journal Jurnal Sains Farmasi dan Kesehatan Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan
Hariyadi Dharmawan Syahputra
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Health Professions Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Evaluasi Formulasi Sediaan Floating Mikroenkapsulasi yang Mengandung Ekstrak Etanol Daun Pepaya (Carica Papaya L.) Glory Stevi Natasia Saragih; Razoki Razoki; Muhammad Yunus; Hariyadi Dharmawan Syahputra
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 1 (2025): Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i1.7052

Abstract

Microencapsulation is a technology that uses controlled release of active ingredients to increase bioavailability and reduce gastrointestinal irritation. This study aims to evaluate the microencapsulation formulation of ethanol extract of papaya leaf (Carica papaya L.) by testing its stability, moisture content, and floating in the stomach and intestinal medium. Mardikasari et al (2020) showed the release of chitosan-alginate microencapsulation of 8,811 mg/L (acid) and 79,908 mg/L (base). Microencapsulation was performed by adding sodium alginate and chitosan as polymers, CaCl2 as a cross-linking, and three variations of extract concentration in F1 without extract, F2 of 0,25%, F3 of 0,5%, and F4 of 0,75%. The results showed that all formulas remained stable during the storage cycle in terms of color, aroma, taste, and texture. The average moisture content of the microencapsulated formulations was 24%, 20,5%, 28%, and 18,7%. The microencapsulated preparations were able to maintain their stability in the acidic conditions in the stomach, but showed a decrease in floating under acidic conditions in the intestine.
Evaluasi Formulasi Sediaan Floating Mikroenkapsulasi yang Mengandung Ekstrak Etanol Kunyit Putih (Curcuma Zedoaria Rosc.) Rika Mai Dinasari Br Sembiring; Razoki Razoki; Erida Novriani; Hariyadi Dharmawan Syahputra
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 1 (2025): Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i1.7054

Abstract

This test aims to evaluate the formulation of floating microcapsule preparations containing ethanol extract of white turmeric (Curcuma zedoaria Rosc.), using chitosan, sodium alginate, and calcium chloride polymers as crosslinking agents. The preparation was formulated using the crosslinking method and tested based on its physical properties, which include moisture content, physical stability through cycle tests, resistance to the gastric and intestinal mucosa. The results showed that the microcapsule formulation was able to maintain the color and texture during the storage period well. The microcapsule durability test showed that the particles could survive in the gastric and intestinal mucosa for two hours. In addition, the water content is within the range that is in accordance with the requirements, namely, at a concentration of 0.25% there is (22%), a concentration of 0.5% there is (38.75%), a concentration of 0.75% there is (22.5%), and the blank has 20.5% water content. Based on previous research by Mardikasari et al., (2020) which used chitosan and alginate polymers. Through this method, this formulation shows the possibility as a technology-based drug delivery system that survives effectively in increasing the bioavailability of active substances from white turmeric.
Uji Aktivitas Antioksidan Ekstrak Etanol Daun Salam (Syzygium Polyanthum (Wight) Walp.) Dengan Metode DPPH Wilson Kanggaran; Razoki, Razoki; Roy Indrianto Bangar Siagian; Hariyadi Dharmawan Syahputra
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.2927

Abstract

Bay leaf (Syzygium polyanthum (Wight) Walp.) is known to contain phenolic and flavonoid compounds with potential as natural antioxidants. This study aims to evaluate the antioxidant activity of ethanol extract of bay leaves using the DPPH method and to identify the bioactive compounds through phytochemical screening and simplicia characterization. Extraction was conducted using maceration with 80% ethanol as the solvent. Characterization result showed that the bay leaf simplicial met the standards of the Farmakope Herbal Indonesia. Phytochemical screening revealed positive results for alkaloids, flavonoids, saponins, tannins, and phenols. The antioxidant activity test showed that the ethanol extract of bay leaves had an IC50 value of 15,45 ppm, which falls into the very strong antioxidant category. These findings reinforce the potential of bay leaf as a natural antioxidant source that can be further developed in pharmaceutical and health applications.
Evaluasi Formulasi Sediaan Mikroenkapsulasi Ekstrak Etanol Herba Seledri (Apium graveolens L.) Najwa Aisyah; Razoki Razoki; Hariyadi Dharmawan Syahputra
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 5 No. 2 (2026): Mei: Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v5i2.6629

Abstract

Celery (Apium graveolens L.) is an herbal plant containing bioactive compounds such as flavonoids, alkaloids, tannins, saponins, and triterpenoids that have the potential to lower blood glucose levels. However, the stability and absorption of its active compounds still need to be developed. One effort to improve the stability and effectiveness of the extract is through microencapsulation technology. This study aims to formulate and evaluate the physical characteristics of microencapsulated preparations containing celery herb ethanol extract. The method used includes making the extract by maceration technique using 80% ethanol, then formulation using alginate and chitosan polymers with ionic gelation method using CaCl2 solution. Evaluation of the preparation includes stability test, water content and adhesion test on the gastric mucosa. The results showed that the microcapsules remained stable, there were no physical changes after six cycles. The adhesion test showed that the extract concentration of 0% (blank) had the highest adhesion ability and the lowest water content was 0.25%.
Evaluasi Formulasi Sediaan Floating Mikroenkapsulasi yang Mengandung Ekstrak Etanol Daun Salam (Syzygium Polyanthum) Rahma Yulina Al-Farini; Razoki Razoki; Muhammad Yunus; Hariyadi Dharmawan Syahputra
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 1 (2025): Januari : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i1.4894

Abstract

Ethanol extract of bay leaves is known to have pharmacological activities such as anti-inflammatory, antihypertensive, and antidiabetic. However, its stability and solubility are still challenges. Therefore, a microencapsulation-based delivery system with floating characteristics that can last longer in the stomach was developed. This study aims to evaluate floating microencapsulation preparations containing ethanol extract of bay leaves (Syzygium polyanthum) as an effort to increase the effectiveness and bioavailability of active substances orally. The results showed that microencapsulation had a total floating of more than 4 hours with a water content of 0.47% -2.14%. Stability tests showed no significant changes in physical and chemical characteristics after cycling tests.
Co-Authors Erida Novriani Glory Stevi Natasia Saragih Muhammad Yunus Najwa Aisyah Rahma Yulina Al-Farini Razoki Razoki Razoki, Razoki Rika Mai Dinasari Br Sembiring Roy Indrianto Bangar S Wilson Kanggaran