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All Journal Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES) Nusantara Scientific Medical Research Journal Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran Jurnal Sains Farmasi dan Kesehatan Galen: Jurnal Ilmu Farmasi dan Kesehatan
Erida Novriani
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Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Analisis Faktor-Faktor yang Mempengaruhi Pengobatan Pasien TB di Puskesmas PB Selayang II Kota Medan Monica Silviyana Simbolon; Erida Novriani; Razoki
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.2642

Abstract

Tuberculosis (TB) is an infectious disease that is one of the leading causes of death in the world. Indonesia ranks second highest in global TB cases, with Medan City being one of the areas with significant cases. This study aims to analyze the factors that influence the treatment of TB patients at the PB Selayang II Health Center in Medan City. The study used a qualitative descriptive method with an in-depth interview approach to ten TB patients until information saturation was reached. The results of the analysis showed that the factors that most influenced the treatment of TB patients were compliance, knowledge, and demographic factors such as age, educations. Family support, personal motivation, and the role of health workers also play an important role in the success of treatment. This study concludes that interventions to improve patient compliance and knowledge, as well as paying attention to socio-economic conditions, are very important in TB control programs at the primary health care level.
Pengaruh Tingkat Pengetahuan dan Tingkat Kepatuhan pada Pasien Tuberkulosis di Puskesmas PB Selayang II Kota Medan Arbita Huri; Erida Novriani; Razoki, Razoki
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.2798

Abstract

Background: Tuberculosis is an infectious disease caused by the bacteria Mycobacterium tuberculosis.Mycobacterium species, including: M. tuberculosis, M. africanum, M. Bovis, M. Leprae are Acid Resistant Bacteria (BTA). in Indonesia TB reached 842,000 cases in 2018 with a mortality of 107,000 cases. With this data, Indonesia is the country with the third highest TB disease in the world. Objective: To determine the effect of Knowledge Level and Compliance Level on TB patients at PB Selayang II health center in Medan City. Methods: the study used quantitative, cross sectional research design approach. The sample in this study were 36 respondents who were willing to use purposive sampling technique, and data collection using a questionnaire. Research Results: the results of data processing on 21 respondents had a sufficient level of knowledge of 58.3% and as many as 27 respondents had a moderate level of compliance of 75.0%. In the Pearson Chi Square results p = 0.003 The results of the correlation analysis with the Chi-Square test can be interpreted that there is an influence between the level of knowledge and the level of compliance with taking medication for Tuberculosis Patients at the PB Selayang II Health Center, Medan City.
Antidiabetic Activity Test of Ethanol Extract of Bandotan Leaves (Ageratum conyzoides L.) in Alloxan-Induced White Rats Puput, Puput Virgia Ningrum; Erida Novriani; Simanjuntak, Nerly Juli Pranita
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 3 No. 01 (2025): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/nsmrj.v3i01.96

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by elevated blood glucose levels, causing significant morbidity and mortality globally. Indonesia is one of the countries with the highest prevalence of diabetes. This study aimed to evaluate the antidiabetic activity of ethanol extract from Bandotan leaves (Ageratum conyzoides L.) in alloxan-induced diabetic white rats. This experimental research used 30 white rats divided into six groups: normal control (distilled water), negative control (distilled water+alloxan), positive control (glibenclamide 0.65 mg/kg BW+alloxan), and three groups receiving ethanol extract of Bandotan leaves (EEBL) at doses of 100, 200, and 400 mg/kg BW with alloxan induction. Extraction of Bandotan leaves was carried out using the maceration method using 96% ethanol, resulting in a yield of 37,35%. Phytochemical screening showed the extract contained alkaloids, steroids, quinones and saponins. Induction of diabetes was carried out by intraperitoneal injection of alloxan 30mg/kgBB. Blood sugar levels were measured on days 5, 10, 15, 20, 25, 30 after induction. The results showed that administration of EEDB significantly (p<0,005) reduced blood sugar levels with the best effect at a dose of 400mg/kgBB. The ethanol extract of bandotan leaves was proven to have effective antidiabetic activity in alloxan- induced mice, with the potential for development as an affordable and easily accessible alternative diabetes therapy.
Relationship Between the Level of Knowledge and Medication Adherence Level in Diabetes Mellitus Patients in Advent Medan Hospital Amazihono, Keytrin; Erida Novriani; Lubis, Asyrun Alkhairi
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 3 No. 01 (2025): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/nsmrj.v3i01.102

Abstract

Hyperglycemia or elevated blood sugar levels due to decreased pancreatic insulin productin, is a sign of a metabolic disorder that leads to diabetes mellitus (DM). One crucial factor in managing diabetes mellitus is the patient’s knowledge and adherence to treatment. Patients with adequate knowledge are more likely to comply with therapy, which helps control the disease. This study aims to determine the relationship between the level of knowledge and the level of medication adherence in diabetes mellitus patients in Advent Hospital Medan. This research employed a quantitative approach with a cross-sectional design and a purposive sampling technique. The research involved 90 patients who were selected and agreed to participate as respondents. Data were collected using a validated Diabetes Knowledge Questionnaire (DKQ-24) and Medication Adherence Report Scale (MARS-5). Data analysis was conducted using a non-parametric statistical test, specifically the Chi-Square test. The study found that the majority of patients had a high level of knowledge (48,9%) but were non-adherent to medication (56,7%). The Chi-Square test showed a significance of 0.001 < 0.05, indicating a significant relationship between the level of knowledge and medication adherence among diabetes mellitus patients at Advent Medan Hospital.
Formulation of Abelmoschus manihot Leaf Gel Using Carbopol and HPMC and Antibacterial Activity Against Pseudomonas aeruginosa Christina Amelia; Nerly Juli Pranita Simanjuntak; Erida Novriani
Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 1 No. 2 (2025): Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : PT Pustaka Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71417/galen.v1i2.18

Abstract

Diabetic foot ulcers are a chronic complication commonly experienced by patients with diabetes mellitus, often caused by Pseudomonas aeruginosa, a pathogenic bacterium with high antibiotic resistance. This study aimed to evaluate the effect of varying concentrations of Carbopol 940 and HPMC bases on the physical characteristics and antibacterial activity of gedi leaf (Abelmoschus manihot) extract gel preparations. The extract was obtained through maceration using 70% ethanol. The gel was formulated into six different formulas: three with HPMC (1%, 2%, and 3%) and three with Carbopol 940 (0.5%, 1%, and 2%), each containing 10% extract. Evaluations included physical characteristics (organoleptic properties, homogeneity, pH, viscosity, spreadability, and stability) and antibacterial activity against P. aeruginosa using the disk diffusion method. The results showed that all formulas met acceptable physical parameters. One-way ANOVA revealed a statistically significant difference in inhibition zone diameters among the formulas (p < 0.001). The formula containing 1% Carbopol exhibited the largest inhibition zone, indicating the most effective antibacterial activity against P. aeruginosa. These findings suggest that gedi leaf extract gel has promising potential as an alternative topical therapy for diabetic foot infections.
Evaluasi Penggunaan Antibiotik Pada Pasien Pneumonia Rawat Inap Di Rsu Mitra Sejati Nerly Juli Pranita Simanjuntak; Tasya Melisa Br Purba; Erida Novriani
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.3104

Abstract

Pneumonia is a lower respiratory tract infection that remains a leading cause of death globally. Irrational use of antibiotics in its treatment worsens antibiotic resistance. This study aims to evaluate antibiotic use in hospitalized pneumonia patients at RSU Mitra Sejati using ATC/DDD and DU90% methods. This descriptive observational study used secondary data from adult inpatient medical records between January and December 2023. Results showed 37 patients, majority male (51.35%), mostly aged 26–35 and 56–65 years. A total of 273 antibiotic uses were recorded, dominated by third-generation cephalosporins, especially Cefixime 200 mg (31.14%). ATC/DDD analysis showed highest DDD/100 days for Cefixime 200 mg (21.04), Levofloxacin 500 mg (18.32), and Ceftriaxone 1 g (12.87). DU90% analysis identified six antibiotics comprising 91.04% of total use, indicating rational use according to national guidelines.
Evaluasi Formulasi Sediaan Floating Mikroenkapsulasi yang Mengandung Ekstrak Etanol Herba Sirih Cina (Peperomia pellucida L.) Cut Inssy Mulun; Razoki Razoki; Erida Novriani
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 4 No. 2 (2025): Agustus : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v4i2.5659

Abstract

Background: Chinese betel (Peperomia pellucida L.) is an herbal plant rich in bioactive compounds such as flavonoids, alkaloids, and tannins that have the potential to be antioxidants, antimicrobials, and antidiabetics. However, the stability and absorption of its active compounds in the body is still a challenge. Microencapsulation technology and  a floating drug delivery sistem (FDDS) can improve the effectiveness and stability of herbal preparations. Objective: This study aims to formulate and evaluate floating microencapsulation preparations containing Chinese betel herb ethanol extract using modern drug delivery technology. Methods: Ethanol extracts were obtained by maceration method and formulated by ionic gelation technique using a combination of sodium alginate and chitosan at three concentration variations (0.25%, 0.5%, and 0.75%). The evaluation included morphological analysis with SEM, ex vivo buoyancy test on the stomach of Wistar rats, determination of moisture content, and physical stability test using the cycling test method. Results: Microencapsulation with a concentration of 0.75% showed the most compact and delicate morphology, the lowest moisture content (0.64%), and the best physical stability. All formulations are capable of floating, with the longest buoyancy time at a concentration of 0.25% for 8 hours. There were no significant physical changes after six cycles of extreme temperatures. Conclusion: Microencapsulation preparations of Chinese betel ethanol extract in a natural polymer-based floating system show good stability and potential as an innovative herbal formulation to extend retention time in the stomach.    
Efektifitas Daun Kersen (Muntingia Calabura L.) Terhadap Profil Histologi Tikus Putih Jantan (Rattus Norvrgicus) Diabetes Mellitus Telaumbanua, David Charles; Erida Novriani; Razoki
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.3242

Abstract

Diabetic mellitus (DM) is a degenerative condition marked by high blood suger levels brought on by a malfunction in the metabolisme of insulin. Serious side effect, such as harm to organs including the pancreas can result from uncontrolled diabetes mellitus the use of medicanal plants, such the kersen leaf (Muntingia calabura L.), which includes active substances like flavonoids, alkaloids, saponins and tannins whith possible antidiabetetic effects, is one altenate therapy option that is presently being investigated. Using male white rats (Rattus norvegicus) with diabetes, this study intends to assess the impact of an ethanolic extract of (Muntingia calabura L.) leaves on the pancreas and identify the optimal dosage for mitigating pancreatic cell damage. Five groups are used in this pure experimental study: three treatment groups that get extract doses of 150,300 and 600 mg/kgBW; a positive control that receives glibencalmide; and a negative control that receives Na CMC. Assessments were made of pancreatic histology and blood glucose levels. The results should offer scientific validation for the long-standing practice of using cherry leaves to treat diabetes.
Uji Aktivitas Formulasi Mikrokapsul Ekstrak Etanol Daun Salam (Syzygium polyanthum) Sebagai Antidislipidemia Terhadap Tikus Putih Stefanus Rio Pendamenta Tarigan; Razoki Razoki; Erida Novriani
Vitalitas Medis : Jurnal Kesehatan dan Kedokteran Vol. 2 No. 4 (2025): Oktober : Vitalitas Medis : Jurnal Kesehatan dan Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/vimed.v2i4.2276

Abstract

Dyslipidemia is a lipid metabolism disorder characterized by elevated levels of total cholesterol, triglycerides, and low-density lipoprotein (LDL) accompanied by decreased levels of high-density lipoprotein (HDL). This condition is a major risk factor for atherosclerosis, coronary heart disease, and stroke. One plant with potential as an antidyslipidemic agent is bay leaves (Syzygium polyanthum). These leaves are known to contain active compounds such as flavonoids, saponins, tannins, alkaloids, and polyphenols that have antioxidant and hypolipidemic activities. The potential of natural compounds from medicinal plants to reduce blood cholesterol levels has gained significant attention in recent years. This study aims to evaluate the effectiveness of microencapsulated ethanol extract of bay leaves in reducing total cholesterol levels in white rats (Rattus norvegicus) induced by a high-cholesterol diet. The experimental study design employed was a laboratory-based true experimental method with a post-test control group design. A total of 25 male rats were used and divided into six groups: normal control, negative control (high cholesterol diet without therapy), positive control (simvastatin), and three groups treated with bay leaf extract microencapsulates at doses of 0.25%, 0.5%, and 0.75%. The treatment was given for 14 days, then total cholesterol levels were measured using an enzymatic method. The results showed that the group with a dose of 0.75% experienced the highest decrease in total cholesterol levels, namely -70 mg/dL, greater than the simvastatin group (-49 mg/dL). Statistical analysis using One Way ANOVA showed a significant difference compared to the negative control (p < 0.001). These findings indicate that the 0.75% dose of microencapsulated Syzygium polyanthum extract demonstrated an effect equal to or greater than simvastatin. Thus, it can be concluded that bay leaf ethanol extract microencapsulates are effective in reducing total cholesterol levels in hypercholesterolemic rats. This suggests that Syzygium polyanthum microencapsulation has the potential to be developed as an alternative phytotherapy for cholesterol reduction.
Uji Efektivitas Ekstra Etanol Daun Salam (Syzygium Polyanthum (Wight) Walp) Terhadap Profil Histologi Pankreas Tikus Putih Jantan (Rattus Norvegicus) Diabetes Melitus Gerhart Frengki Hardian Harefa; Erida Novriani; Asyrun Alkhairi Lubis
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.3339

Abstract

ABSTRACT Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia due to impaired insulin secretion or function, which can damage organs, including the pancreas. Natural treatment alternatives are needded because conventional drugs cause side effects. Bay leaf, also known as Syzygium polyanthum (Wight) Walp, contains bioactive compounds like flavonoids, tannins, and saponins that have potential to fight diabetes and protect pancreatic tissue. The aim of this study is to determine the effect of bay leaf extract on the histology of the pancreas in diabetic rats and to identify the optimal dose to reduce pancreatic tissue damage. This study used 25 male Rattus norvegicus rats and was conducted experimentally with a pretest-posttest control group design. The rats were divided into 6 groups: normal control, negative control (NaCMC), positive control (metformin), and three treatment groups given bay leaf extract at doses of 200 mg/kgBW, 300 mg/kgBW, and 400 mg/kgBW. For 15 days, the extract was administered orally, and blood glucose was measured; therefore, bay leaf extract can be used as an alternative to improve pancreatic damage caused by diabetes.
Co-Authors Amazihono, Keytrin Arbita Huri Asyrun Alkhairi Lubis Christina Amelia Cut Inssy Mulun Devortivo Hartono Putra Gerhart Frengki Hardian Harefa Lubis, Asyrun Alkhairi Monica Silviyana Simbolon Nerly Juli Pranita Simanjuntak Puput, Puput Virgia Ningrum Razoki Razoki Razoki Razoki, Razoki Simanjuntak, Nerly Juli Pranita Stefanus Rio Pendamenta Tarigan Tasya Melisa Br Purba Telaumbanua, David Charles