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All Journal Majalah Patologi Indonesia Health and Medical Journal
Yona, Fajriza
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Association of α-SMA and EpCAM Expressions with Recurrence Risk Based on Histopathological Subtypes of Basal Cell Carcinoma Yona, Fajriza; Hilbertina, Noza; Mulyani, Henny; Bachtiar, Hafni
Majalah Patologi Indonesia Vol. 33 No. 1 (2024): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i1.613

Abstract

Background Basal cell carcinoma (BCC) is the most common skin malignancy in the world with a proportion 70%. Recurrent and aggressive variants are still challenging in diagnosis and treatment. Histopathologically, there are two group of BCC risk of recurrence, i.e low risk and high risk. Assessment the expression of alpha-smooth muscle actin (α-SMA) as a biomarker of cancer associated fibroblast cell in stroma and the expression of epithelial cell adhesion molecule (EpCAM) in tumor cells probably have role in the pathomechanism of BCC progression, suggest its can distinguish the risk of BCC recurrence. This research aims to determine the assosiation between the expression of α-SMA and EpCAM with the recurrence risk group of BCC histopathological subtypes. Methods This was a cross sectional study using 48 samples, with 24 low and high risk groups each. Histopathological subtypes were determined from Hematoxylin and eosin slide. The expression of α-SMA and EpCAM was examined by the immunohistochemical method which was assessed semiquantitatively. Statistical analysis was performed using the Chi-square test with p<0.05 was considered significant. Results Expression of α-SMA with the score 3 was found more in high risk BCC (85.7%), while a score of 1 was more in low risk BCC (100%). Loss of EpCAM expression was mainly found in high risk BCC (82.8%). Statistical analysis showed that there was a significant assosiation between the expression of α-SMA and EpCAM and the recurrence risk group of BCC histopathological subtypes with p value =0.000 for each. Conclusions This study concluded that increased of α-SMA expression and loss of EpCAM expression were associated with a high recurrence risk group of BCC histopathological subtypes.
Plasma Cell Myeloma dengan Temuan Histopatologi pada Tulang Humerus Yona, Fajriza
Health and Medical Journal Vol 4, No 2 (2022): HEME May 2022
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (255.693 KB) | DOI: 10.33854/heme.v4i2.982

Abstract

Pendahuluan: Plasma cell myeloma  merupakan keganasan tulang primer yang paling sering dijumpai dengan keluhan utama nyeri tulang belakang, dan jarang dengan gejala awal nyeri pada humerus. Diagnosis didasarkan pada temuan klinis, radiologis dan histopatologis.  Laporan Kasus: Kami melaporkan kasus seorang laki-laki berusia 60 tahun datang dengan keluhan nyeri pada lengan atas kanan dan gangguan berkemih. Sebelumya pasien memiliki riwayat nyeri tulang belakang dengan dugaan fraktur kompresi torakal 12 akibat metastase. Hasil reseksi prostat transuretra (TURP) menunjukkan hiperplasia prostat. X-ray humerus memberikan hasil simple bone cyst dan CT scan dada menunjukkan  chondroma.Pemeriksaan laboratorium tampak anemia ringan, normokalsemia, serta kreatinin normal. Bone survei tampak beberapa punched out lytic lession pada tengkorak, mandibula, klavikula dan panggul. Biopsi humerus dilakukan, hasil histopatologi adalah Plasma cell myeloma, well differentiated. Imunohistokimia CD138 memberikan hasil positif difus. Kesimpulan: Dalam kasus klinis non-spesifik, diagnosis yang akurat diperoleh dari patologi. Dalam hal ini, hasil histopatologi adalah sel plasma neoplastik yang difus, dibuktikan dengan penanda CD138 positif difus dan diagnosis didukung oleh anemia dan lesi litik tulang yang multipel.
Co-Authors Hafni Bachtiar henny Mulyani Noza Hilbertina, Noza