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The Role of Tumor Necrosis Factor  (TNF ) and Matrix Metalloproteinase9 (MMP9) Serum in Preterm Premature Rupture of Membranes Ardiles, Ardiles; Desmiwarti, Desmiwarti; Bachtiar, Hafni
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 4, October 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To investigate the role of TNF- and MMP-9 serum in preterm premature rupture of membranes (PPROM). Methods: We used cross-sectional study design. Subjects were all pregnant women with and without PPROM who underwent checkup at Obstetrics and Gynecology Functional Medical Staff General Hospital Dr. M. Djamil and networking hospital. Results: A total of 48 subjects were enrolled in this study. The mean serum levels of TNF- in patients with PPROM 17.43 ng/ml  12.4 ng/ml and without PPROM 8.45 ng/ml  6.86 ng/ml. The mean serum levels of MMP-9 in patients with PPROM 8.77 ng/ml  4.41 ng/ml, and without PPROM 4.46 ng/ml  3.04 ng/ml. Statistical test result p value <0.05, it can be conclude there are differences in the levels of TNF- and MMP-9 serum in premature rupture of membranes and without premature rupture of membranes pregnancy of preterm. Conclusion: There are differences in the levels of TNF- and MMP-9 serum in PPROM and without PPROM.Keywords: MMP-9, premature rupture of membranes, TNF-

KAJIAN FAKTOR ORGANISASI DENGAN KINERJA PERAWAT PELAKSANA DALAM PENDOKUMENTASIAN ASUHAN KEPERAWATAN DI RUANG RAWAT INAP RSUD PARIAMAN Murni, Dewi; Bachtiar, Hafni; Sasmita, Happi
Ners Jurnal Keperawatan Vol 12, No 1 (2016)
Publisher : Fakultas Keperawatan Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/njk.12.1.1 - 14.2016

Dokumentasi asuhan keperawatan merupakan bukti pencatatan dan pelaporan yang dimiliki perawat dalam asuhan keperawatan yang berguna bagi pasien, perawat dan tim serta tanggung jawab perawat. Dokumentasi yang efektif menjamin kesinambungan pelayanan, menghemat waktu, dan meminimalisasi resiko kesalahan. Pelaksanaan dokumentasi keperawatan sebagai salah satu alat ukur untuk mengetahui, memantau dan menyimpulkan suatu pelayanan asuhan keperawatan yang diselenggarakan oleh Rumah Sakit. Data menunjukkan pendokumentasian asuhan keperawatan masih rendah (49,5%), dengan ketentuan RSUD Pariaman mengunakan asuhan keperawatan adalah 65% sedangkan, menurut Depkes 80%. Kinerja Perawat dalam pelaksanaan asuhan keperawatan dipengaruhi oleh faktor organisasi (Kepemimpinan kepala ruangan, imbalan, supervisi dan pembinaan). Tujuan penelitian ini untuk melihat factor organisasi yang berhubungan dengan kinerja perawat dalam pelaksanaan asuhan keperawatan di RSUD Pariaman. Penelitian ini menggunakan desain cross sectional. Populasi dan sampel dalam penelitian ini adalah perawat pelaksana di RSUD Pariaman dengan jumlah sampel 89 orang, dengan teknik pengambilan sampel Simpel random sampling. Instrument yang digunakan angket. Hasil uji statistik bivariat chi-square menunjukkan bahwa ada hubungan yang bermakna antara kepemimpinan (p = 0,000), imbalan (p = 0,005), supervisi (p = 0,000) dan pembinaan (p = 0,003). Rekomendasi bagi Direktur RSUD Pariaman untuk meningkatkan supervisi di setiap ruangan, kepemimpinan, imbalan dan pembinaan terhadap pelaksanaan asuhan keperawatan kepada perawat pelaksana.

The Role of Tumor Necrosis Factor  (TNF ) and Matrix Metalloproteinase9 (MMP9) Serum in Preterm Premature Rupture of Membranes Ardiles, Ardiles; Desmiwarti, Desmiwarti; Bachtiar, Hafni
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 4, October 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To investigate the role of TNF- and MMP-9 serum in preterm premature rupture of membranes (PPROM). Methods: We used cross-sectional study design. Subjects were all pregnant women with and without PPROM who underwent checkup at Obstetrics and Gynecology Functional Medical Staff General Hospital Dr. M. Djamil and networking hospital. Results: A total of 48 subjects were enrolled in this study. The mean serum levels of TNF- in patients with PPROM 17.43 ng/ml  12.4 ng/ml and without PPROM 8.45 ng/ml  6.86 ng/ml. The mean serum levels of MMP-9 in patients with PPROM 8.77 ng/ml  4.41 ng/ml, and without PPROM 4.46 ng/ml  3.04 ng/ml. Statistical test result p value <0.05, it can be conclude there are differences in the levels of TNF- and MMP-9 serum in premature rupture of membranes and without premature rupture of membranes pregnancy of preterm. Conclusion: There are differences in the levels of TNF- and MMP-9 serum in PPROM and without PPROM.Keywords: MMP-9, premature rupture of membranes, TNF-

PERBEDAAN EFEK MISOPROSTOL DAN OKSITOSIN SEBAGAI PEMATANGAN SERVIKS Lasmini, Putri Sri; Yunitra, Imelda; Bachtiar, Hafni
Andalas Obstetrics And Gynecology Journal Vol 3, No 2 (2019)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aogj.3.2.119-122.2019

Berbagai penelitian dilakukan untuk menilai efektifitas misoprostol dan oksitosin tersebut, bahkan be- berapa penelitian membandingkan pemakaian misoprostol dan oksitosin sebagai induksi persalinan, Berdasarkan bebagai penelitian tersebut terlihat bahwa tampak pengaruh yang berbeda dari misoprostol dan oksitosin pada fase perturisi mulai pematangan serviks, kontraksi uterus hingga keberhasilan persa- linan. Bila dibandingkan dengan oksitosin, maka misoprostol sebagai obat yang mudah didapatkan, mu- rah dan efektif, sebagai agen pematangan serviks dibanding dengan oksitosin. Penelitian ini merupakan penelitian eksperimental pre-post kontrol group desain untuk menilai proporsi perbedaan efek pemberi- an misoprostol dan oksitosin pada pematangan serviks, Penelitian dilakukan di RS Dr.M.Djamil Padang dan RS jejaring. Waktu penelitian mulai januari 2014 sampai bulan oktober 2014, Variabel bebas adalah pematangan serviks dengan menggunakan misoprostol 25 ?g dan drip oksitosin. Variabel tergantung adalah terjadi atau tidaknya pematangan serviks dan penilaian kenaikan Bishop skor. Rata-rata pematan- gan serviks dengan misoprostol lebih tinggi atau lebih besar dibanding dengan oksitosin yaitu 7,0968 ± 2,11904 berbanding dengan 2,5806±3,36427. Secara statistik perbedaan ini signifikan dengan p < 0,05. Misoprostol adalah agen pematangan serviks yang lebih baik daripada oksitosin, Oksitosin sebaiknya diberikan pada serviks yang matang.Kata Kunci : Preeklampsia berat, asam folat, hamil normal.

Pengaruh tonsiloadenoidektomi terhadap kadar insulin-like growth factor-1 pada anak dengan obstructive sleep apnoea syndrome Hafiz, Al; Novialdi, Novialdi; Yerizel, Eti; Bachtiar, Hafni
Oto Rhino Laryngologica Indonesiana Vol. 45 No. 2 (2015): Volume 45, No. 2 July - December 2015
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v45i2.115

Latar belakang: Infeksi kronis pada tonsil palatina disertai pembesaran tonsil palatina, dapat menyebabkan sumbatan pada jalan nafas bagian atas. Gangguan pertumbuhan banyak ditemukan pada kelompok pasien ini. Tujuan: Mengetahui apakah ada pengaruh tindakan tonsiloadenoidektomi terhadap kadar serum insulin-like growth factor-1 (IGF-1) dan nilai body mass index (BMI) pada anak yang menderita hipertrofi tonsil palatina dan adenoid, dengan gejala obstructive sleep apnoea syndrome (OSAS). Metode: Desain penelitian adalah eksperimental dengan studi pre- dan post-trial, dengan membandingkan kadar IGF-1 dan nilai BMI dalam serum anak dengan gejala OSAS, sebelum dan tiga bulan setelah dilakukan tonsiloadenoidektomi. Hasil: Sesuai protokol penelitian terdapat 14 subjek penelitian, menunjukkan peningkatan nilai kadar IGF-1 dan nilai BMI. Tindakan tonsiloadenoidektomi terbukti dapat meningkatkan kadar hormon pertumbuhan, yang tergambar dari peningkatan kadar IGF-1 dan nilai BMI. Kesimpulan: Tindakan tonsiloadenoidektomi berpengaruh terhadap peningkatan kadar hormon pertumbuhan, yang disimpulkan melalui pengukuran kadar IGF-1 dan nilai BMI dalam serum anak dengan gejala OSAS. Kata kunci: tonsiloadenoidektomi, insulin-like growth factor-1, obstructive sleep apnoea syndromeABSTRACT Background: Chronic infection with the enlargement of the palatine tonsil, could cause blockage of the upper airway. Growth disorders are common in this patient group. Purpose: To determine the effect of tonsilloadenoidectomy on the level of serum IGF-1 in children with palatine tonsil and adenoid hypertrophy and obstructive sleep apnoea syndrome (OSAS) symptoms. Methods: The study design was experimental, pre-and post-study, by comparing the serum levels of IGF-1 and the value of Body Mass Index (BMI) in children with OSAS symptoms, before and three months after tonsiloadenoidectomy. Result: According to the study protocol, there were 14 subjects showed increased levels of IGF-1 and BMI values. Tonsilloadenoidectomy was shown to increase the growth hormone levels, which was reflected from the increased levels of IGF-1 and BMI. Conclusion: Tonsiloadenoidectomy affected the increased levels of growth hormone, which was concluded through the measurement of the levels of IGF-1 and the value of BMI in the serum of children with symptoms of OSAS. Keywords: tonsilloadenoidectomy, insulin-like growth factor-1, obstructive sleep apnea syndrome

META-ANALISIS FAKTOR RISIKO INTERNAL DAN KOMORBID YANG BERHUBUNGAN DENGAN KEJADIAN PENYAKIT TUBERKULOSIS DI WILAYAH ASIA Primasari, Eka Putri; Bachtiar, Hafni; Lestari, Yuniar
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 3 (2024): DESEMBER 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i3.33272

Tuberkulosis (TB) merupakan penyakit infeksi menular pembunuh nomor satu di dunia. Secara global, diperkirakan 10,0 juta (kisaran, 8,9-11,0 juta) orang terkena penyakit TB pada tahun 2019. Secara geografis, sebagian besar orang yang mengembangkan TB pada tahun 2019 berada di wilayah WHO Asia Tenggara (44%). Faktor internal seperti usia, jenis kelamin, status gizi, imunisasi BCG dan adanya komorbid seperti infeksi penyakit HIV dan diabetes merupakan faktor risiko penyakit tuberkulosis. Penelitian ini bertujuan mengetahui hubungan faktor risiko internal dan komorbid terhadap kejadian tuberkulosis di Asia. Penelitian ini merupakan penelitian kuantitatif dengan desain studi meta-analisis. Meta-analisis dilakukan terhadap penelitian dengan desain studi kohort dan kasus-kontrol, terpublikasi sejak Januari 1980 sampai Maret 2016, melalui database PubMed, ProQuest, EBSCO dan BioMed Central. Perhitungan pooled odds ratio (OR) dengan asumsi fixed effect model atau random effect model. Data diolah menggunakan RevMan 5.3. Penelitian ini mereview 11.605 artikel, melibatkan 19 artikel ke dalam meta-analisis. Hasil penelitian menunjukkan terdapat hubungan yang signifikan terhadap status gizi <18,5 kg/m2, (OR: 3,71; 95%CI: 1,15 – 12,01), tidak imunisasi BCG (OR: 1,86; 95%CI 1,35 – 2,57), pernah diimunisasi BCG (OR: 0,54; 95%CI: 1,44 – 3,16) dan penyakit diabetes (OR: 1,82; 95% CI 1,51 – 2,18) dengan penyakit TB di wilayah Asia. Kesimpulannya faktor risiko internal dan komorbid yang berhubungan dengan kejadian penyakit TB di wilayah Asia ialah status gizi <18,5 kg/m2, tidak diimunisasi BCG, dan penyakit DM.

EFEK SUPLEMEN KAPSUL JAHE MERAH TERHADAP REFLUX LARINGOFARINGEAL: Red Ginger and LPR Asyari, Ade; Julianda, Wahyu; Aliska, Gestina; Bachtiar, Hafni; Octavia, Tri Aryanti; Diflayzer, Diflayzer
Oto Rhino Laryngologica Indonesiana Vol. 54 No. 2 (2024): VOLUME 54, NO. 2 JULY - DECEMBER 2024
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v54i2.690

Background: Ginger (Zingiber officinale) is a popular rhizome plant that used as a cooking and medicinal ingredient. Ginger contains many active compounds, such as phenolic and terpenes. Ginger has an anti-inflammatory effect through active ingredients, including diarylheptanoids, oleoresin, gingerol, shogaol and zingerone. Ginger powder is often used as a remedy for gastric acid reflux. In laryngopharyngeal reflux, there is a damage to the laryngopharyngeal mucosa due to irritation of gastric acid and pepsin. Purpose: To analyze the effect of red ginger powder capsule supplementation (Zyngiber officinale var. rubrum) on laryngopharyngeal reflux. Method: Non-randomized control trial study with a pretest-posttest control group design in laryngopharyngeal reflux. The patients were divided into two groups, where each group was examined for Reflux Symptom Index (RSI) and Reflux Finding Score (RFS). The intervention group was given red ginger powder capsules and lansoprazole, while the control group was given lansoprazole only; then a month later, both groups were examined for RSI and RFS finding score. Data were analyzed statistically with a computer program and were declared significant if p<0.05. Result: There was a significant difference between RSI and RFS in the intervention group, and there was no significant difference between RSI and RFS in the control group. Meanwhile, there were significant differences in RSI and RFS between the control and intervention groups. Conclusion: There was a significant difference between the reflux symptom index and reflux finding score between the intervention group and the control group. Keywords: red ginger, Zingiber officinale var. rubrum, laryngopharyngeal reflux, reflux symptom index, reflux finding score ABSTRAK Latar belakang: Jahe (Zingiber officinale) merupakan tanaman rimpang yang populer digunakan sebagai bahan masakan dan obat. Jahe mengandung banyak senyawa aktif, seperti senyawa fenolik dan terpena. Jahe memiliki efek anti-inflamasi melalui kandungan aktifnya, antara lain diarylheptanoida, oleoresin, gingerol, shogaol dan zingeron. Bubuk jahe sering digunakan sebagai pengobatan pada kasus refluks asam lambung. Pada kelainan refluks laringofaring, terjadi kerusakan pada mukosa laringofaring akibat iritasi asam lambung dan pepsin. Tujuan: Menganalisis pengaruh suplementasi kapsul serbuk jahe merah (Zingiber officinale var. rubrum) terhadap refluks laringofaring. Metode: Menggunakan metode non-randomized control trial, dengan pendekatan pretest-posttest control group design pada refluks laringofaring. Pasien dibagi menjadi dua kelompok, dan masing-masing kelompok diperiksa indeks gejala refluks, dan skor temuan refluks. Pada kelompok intervensi diberikan kapsul serbuk jahe merah dan lansoprazole, sedangkan pada kelompok kontrol diberikan lansoprazole saja; selanjutnya, satu bulan kemudian dilakukan pemeriksaan indeks gejala refluks dan skor temuan refluks. Data dianalisis secara statistik dengan program komputer dan dinyatakan signifikan jika p<0,05. Hasil: Terdapat perbedaan yang signifikan antara indeks gejala refluks dan skor temuan refluks pada kelompok intervensi, dan tidak terdapat perbedaan yang signifikan antara indeks gejala refluks dan skor temuan refluks pada kelompok kontrol. Sementara itu, terdapat perbedaan yang signifikan pada indeks gejala refluks dan skor temuan refluks antara kelompok kontrol dan intervensi. Kesimpulan: Terdapat perbedaan yang signifikan antara indeks gejala refluks dan skor temuan refluks antara kelompok intervensi dan kelompok kontrol. Kata kunci: jahe merah, Zingiber officinale var. rubrum, refluks laringofaring, indeks gejala refluks, skor temuan refluks

PENGGUNAAN SELAPUT AMNION SEGAR PADA INSISI LUKA OPERASI SEKSIO SESAREA Adnani, Syahredi Syaiful; Bachtiar, Hafni
Andalas Obstetrics And Gynecology Journal Vol. 1 No. 2 (2017)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.1.2.47-55.2017

In the last few decades, the incidence of caesarean section is increasing in the world, especially in Indonesia. One of the way to treat tissue scar is through biologic and synthetic dressing where nowadays, amnion has been used as biologic dressing frequently. This study was conducted to determine the effect of the use of fresh amniotic membrane on wound incision Caesarean section compared with Caesarean section incision wound covered using regular gauze bandages and fixated with plaster in RS. Dr. Reksodiwiryo Padang. The design of this study is an experimen-tal study with Post test design with control group design. Sampling was done using a formula consecutive sampling two different test samples obtained an average of 72 people for each group. The analysis used include univariate and bivariate analyzes. The average wound healing time the difference was statistically significant (p value <0.05) in the treatment and control groups. There was highly significant difference in the proportion of local infection on day 3 between the treatment and control groups (p value <0.05). There were very significant differences in the proportion of local allergic reactions at day 3, and 5 between the treatment and control group (p <0.05). There are significant differences in terms of the cost of care per day between treatment and control groups (p <0.05). From this study, the average wound healing time has a very significant difference.Keywords: Fresh Amniotic Membrane, Wound Cesarean Section, Wound Healing

PENGARUH PENGIKATAN ALAT KONTRASEPSI DALAM RAHIM TERHADAP KONTINUITAS PADA PEMASANGAN KELUARGA BERENCANA PASCA SALIN METODE TRANSESAREA Ariadi, Ariadi; Bachtiar, Hafni
Andalas Obstetrics And Gynecology Journal Vol. 2 No. 2 (2018)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.2.2.109-114.2018

The insertion of an intrauterine device (IUD) is installed immediately after delivery has been recommended by the WHO, as one method of contraception is safe and effective for interim and prevent missed opportunity (unmet need). IUD insertion after childbirth can avoid the discomfort that usually occurs during the interval insertion, and lochia can obscure any bleeding from the insertion. However, post-partum IUD insertion has disadvantages as well. The risk of the possibility of spontaneous expulsion is very high. This study is an experimental study with the method of post-test control group design to determine differences in IUD expulsion rate tied and not tied when installed during caesarean section at RSUP. Dr.M.Djamil in Padang, and Military Hospital Reksodiwiryo Padang and Painan District Hospital. There were no significant differences between trancaesarean IUD insertion methods that are not tied or tied (P> 0.05). The percentage of expulsion is not tied 11.4% higher compared to 0% tied expulsion. Statistically, were not significant differences as obtained P value> 0.05.Keywords: IUD, tied, trancaesarean

PERBEDAAN KADAR ASAM FOLAT SERUM PENDERITA ABORTUS SPONTAN DENGAN KEHAMILAN NORMAL Ermawati, Ermawati; Bachtiar, Hafni
Andalas Obstetrics And Gynecology Journal Vol. 2 No. 1 (2018)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.2.1.53-61.2018

Abortion is the termination of pregnancy before fetus can survive in the outside world, regardless of the cause. One cause of spontaneous abortion due to maternal nutritional factors, such as folic acid defi-ciency, lead to disruption of cell function and ends with apoptosis as well as continuing with fetal death. The study was conducted to determine differences in the levels of folic acid serum between patients with normal pregnancy and spontaneous abortion in some hospitals in West Sumatra. The study was con-ducted by the method of analytic observational comparative cross-sectional design. This research was carried out on pregnant women who come to the clinic and emergency obstetric Dr.M.Djamil hospital Padang, Batusangkar Hospital, Reksodiwiryo Hospital Padang and examinations conducted in biomed-ical laboratory medical faculty Andalas University the period August-December 2014. The total number of women included in the statistical calculation after the inclusion and exclusion criteria are met is 54 people, statistical analysis was done afterwards. The mean levels of serum folic acid is lower in sponta-neous abortion patients compared with average levels of folic acid in normal. Results of statistical anal-ysis using t-test found significant differences in the mean serum levels of folic acid group of spontaneous abortion patients with normal pregnancy group, it can be seen from p-value 0.001 (p <0.05).Keywords: Spontaneous abortion, folic acid, fetus death

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