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All Journal Indonesian Journal of Global Health research Jurnal Kesehatan Tambusai
Chendra, Wijaya Johanes
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Dentistry Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health

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Identification of Potential Regulatory Genes Associated with Chondrosarcoma using Integrated Bioinformatic Analysis Ismail, Mohamad Dimas; Hasan, Firman; Chendra, Wijaya Johanes
Indonesian Journal of Global Health Research Vol 5 No 4 (2023): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v5i4.2111

Abstract

Identifying the novel critical regulatory genes in the molecular processes driving chondrosarcoma (CS) growth is essential for establishing targeted therapeutic approaches. Objective: This study aims to investigate the core regulatory genes implicated in the molecular mechanisms of CS progression. Method: We conducted a dataset search from the Gene Expression Omnibus (GEO) database using “chondrosarcoma” as the keyword. DAVID database was utilised to obtain the Gene Ontology (GO) and pathways enrichment of DEGs. Interaction between the proteins network was constructed using the STRING database and visualised by Cytoscape (3.10.0) software. Subsequently, the essential genes were identified as the intersected genes from cytoHubb and MCODE plugin. Furthermore, we analysed these genes based on their expression and survival using the UALCAN database. Additionally, the cBioPortal database and Tumor Immune Estimation Resource (TIMER) were utilised to obtain the genetic alteration and immune cell infiltration associated with the hub genes. Moreover, the NetworkAnalyst database was deployed to construct the interactions between microRNAs (miRNAs) and the hub genes. Results: 114 common DEGs were found between two datasets (GSE30844 and GSE48418). These genes are predominantly associated with Focal Adhesion. Seven hub genes were identified which include CCND1, CDK6, CAV1, MLC1, SQSTM1, GAPDH, and FOXO1. The validation analysis revealed a diagnostic value amidst the hub genes, particularly CDK6 and FOXO1 genes associated with unfavorable outcome in sarcoma patients. The miRNAs analysis demonstrated that miR-15a-5p has a potential binding with CDK6 and FOXO1. Conclusions: This study revealed seven core genes and indicated a putative regulatory molecule associated with CS progression. Taken together, this study's findings suggest that the CDK6, FOXO1, and miR-15a-5p have a potential role in regulating CS progression.
KOMITMEN MUTU LAYANAN DAN KUALITAS PELAYANAN PRIMA TERHADAP KEPUASAN PASIEN DAN IMPLIKASINYA PADA REPUTASI RUMAH SAKIT (Studi Survei Pada Pasien JKN di RS Swasta Ambon) Chendra, Wijaya Johanes; Mulyani, Sri Rochani; Rulia, Rulia; Yuliaty, Farida; Wirawan, Chevie
Jurnal Kesehatan Tambusai Vol. 5 No. 2 (2024): JUNI 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i2.28659

Abstract

Komitmen mutu layanan adalah pelaksanaan serta pelayanan publik yang memiliki orientasi pada kualitas dan hasil. Penelitian ini bertujuan untuk menganalisis komitmen mutu layanan, kualitas pelayanan prima, kepuasan pasien dan reputasi Rumah Sakit di Rumah Sakit Swasta Ambon. Penelitian ini menggunakan pendekatan kuantitatif. Sampel dalam penelitian ini berjumlah 100 responden. Analisis data yang digunakan adalah analisis deskriptif dan analisis verifikatif menggunakan analisis jalur (path analysis). Hasil penelitian analisis deskriptif terhadap komitmen mutu layanan, kualitas pelayanan prima, kepuasan pasien dan reputasi Rumah Sakit dengan penilaian cukup baik menuju baik, masih ditemukan beberapa kekurangan yang harus diperhatikan untuk diperbaiki. Sedangkan hasil penelitian verifikatif, model analisis jalur menunjukkan nilai koefisien jalur komitmen mutu layanan terhadap reputasi Rumah Sakit bernilai positif dan nilai koefisien jalur pengaruh tidak langsung lebih besar dari pengaruh langsung (12,0%>4,1%), demikian juga kualitas pelayanan prima terhadap reputasi Rumah Sakit bernilai positif dan nilai koefisien pengaruh tidak langsung lebih besar dari pengaruh langsung (22,4%>18,2%) artinya kepuasan pasien sebagai variabel intervening mampu memediasi komitmen mutu layanan maupun kualitas pelayanan prima terhadap reputasi Rumah Sakit. Hasil hipotesis statistik untuk uji-t (parsial), komitmen mutu layanan berpengaruh positif dan signifikan terhadap reputasi Rumah Sakit. Untuk uji-F (simultan), komitmen mutu layanan dan kualitas pelayanan prima terhadap kepuasan pasien berpengaruh positif. Hasil penelitian secara keseluruhan menunjukkan adanya implikasi variabel komitmen mutu layanan, kualitas pelayanan prima dan kepuasan pasien terhadap reputasi Rumah Sakit.
Co-Authors Farida Yuliaty Hasan, Firman Ismail, Mohamad Dimas mulyani, sri rochani Rulia, Rulia Wirawan, Chevie