<![CDATA[The prevalence of cancer cases in children continues to increase, requiring appropriate and high-quality management, one of which is chemotherapy. Children undergoing chemotherapy often experience fatigue problems. Fatigue is a subjective, difficult and persistent feeling of physical, emotional and cognitive fatigue in children. This condition makes the child unable to function due to decreased energy levels that cannot be recovered by rest. so this will affect the quality of life. The aim of this study was to determine the relationship between fatigue and the quality of life of children with cancer undergoing chemotherapy at Dr M Djamil Hospital, Padang. The research uses a correlation analytical research design with a cross sectional study approach. The respondents in this study were 96 children undergoing chemotherapy. The instruments used were the Multidimensional Fatigue Scale and Pediatric Quality of Life Cancer Module 3.0 questionnaires. Internal consistency reliability results show Cronbach Alpha results of 0.912 for child reports and 0.910 for parent reports. Data were analyzed analysis using the Chi Square test and to identify confounding variables using multiple logistic regression analysis by looking at changes in the odds ratio value for each variable. In general, children in the preschool-school age stage (77.9%), male (54.2%), duration of chemotherapy treatment < 12 months (85.4%), have poor quality of life (55.2%), experienced severe fatigue (57.3%), and received supportive family support (52.1%). The results of this study show that there is a significant relationship between fatigue and the quality of life of children undergoing chemotherapy (p < 0.001). Based on the confounding analysis, it was found that family support is the factor that has the most influence on quality of life.]]>
