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All Journal Journal of Food and Pharmaceutical Science JURNAL PENDIDIKAN TAMBUSAI Journal of Food and Pharmaceutical Sciences
Repuja, Dira
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Social Sciences

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Edukasi dan Konsultasi Terkait Waktu Penggunaan Obat Antihipertensi bagi Pasien yang Menjalankan Ibadah Puasa untuk Menunjang Kesehatan Anggraini, Deni; Octaviani, Melzi; Sinata, Novia; Idzan, Nur Kamilah; Repuja, Dira; Fitri, Eliza; Safitri, Elsa; Annisa, Annisa; K, Della Yunita Sary.; Amanda, Denisya; Ezuela, Deska Z; Anggraini, Dhiva; Sari, Fatwa Aulia
Jurnal Pendidikan Tambusai Vol. 9 No. 2 (2025): Agustus
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai, Riau, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jptam.v9i2.31482

Abstract

Puasa Ramadhan mengubah pola makan dan waktu penggunaan obat secara signifikan, terutama pada pasien dengan penyakit kronis seperti hipertensi. Edukasi penggunaan obat antihipertensi sangat penting agar pasien tetap memperoleh efek terapi optimal selama berpuasa. Kegiatan ini bertujuan untuk meningkatkan pemahaman masyrakat khususnya lansia, tentang waktu konsumsi obat antihipertensi selama bulan Ramadhan kegiatan dilaksanakan pada 15 maret 2025 di UPT PSTW Husnul Khotimah, Pekanbaru, dalam bentuk sosialisasi dan konsultasi. Hasil evaluasi menunjukkan peningkatan pemahaman peserta setelah edukasi
Increased Dissolution Rate of Solid Dispersion Fenofibric Acid PEG 6000 and In Vivo Study Anggraini, Deni; Agistia, Nesa; Fernando, Armon; Yulia, Amanda; Repuja, Dira
Journal of Food and Pharmaceutical Sciences Vol 14, No 2 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26376

Abstract

Fenofibrate acid is a fibrate drug with high permeability but low water solubility, resulting in limited bioavailability. Solid dispersion using hydrophilic carriers is one strategy to increase solubility. The objective of this study was to improve the solubility of fenofibric acid by converting it into a solid dispersion system using PEG 6000 as a carrier. Preparation of solid dispersion systems by the melting method. The fenofibric acid PEG 6000 weight ratios were F1 (1:1), F2 (1:3), and F5 (1:5). Physicochemical characterization of the solid dispersions included DSC, PXRD, FTIR, and SEM tests, as well as dissolution and bioavailability tests with the determination of pharmacokinetic parameters. Characterization results show that fenofibric acid with PEG 6000 as a carrier still exhibits a crystalline phase but with reduced intensity, resulting in increased solubility and dissolution rate. Dissolution test show that solid dispersion F3 (1:5) dissolves faster (78.7%) than pure fenofibric acid (53.2%). after 60 minutes. Pharmacokinetic parameter determination tests showed no significant difference between pure fenofibric acid and solid dispersion. Solid dispersion of fenofibric acid with PEG 6000 as a carrier can improve the physicochemical performance and dissolution rate of fenofibric acid but pharmacokinetic parameters did not differ significantly.
Increased Dissolution Rate of Solid Dispersion Fenofibric Acid PEG 6000 and In Vivo Study Anggraini, Deni; Agistia, Nesa; Fernando, Armon; Yulia, Amanda; Repuja, Dira
Journal of Food and Pharmaceutical Sciences Vol 14, No 2 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26376

Abstract

Fenofibrate acid is a fibrate drug with high permeability but low water solubility, resulting in limited bioavailability. Solid dispersion using hydrophilic carriers is one strategy to increase solubility. The objective of this study was to improve the solubility of fenofibric acid by converting it into a solid dispersion system using PEG 6000 as a carrier. Preparation of solid dispersion systems by the melting method. The fenofibric acid PEG 6000 weight ratios were F1 (1:1), F2 (1:3), and F5 (1:5). Physicochemical characterization of the solid dispersions included DSC, PXRD, FTIR, and SEM tests, as well as dissolution and bioavailability tests with the determination of pharmacokinetic parameters. Characterization results show that fenofibric acid with PEG 6000 as a carrier still exhibits a crystalline phase but with reduced intensity, resulting in increased solubility and dissolution rate. Dissolution test show that solid dispersion F3 (1:5) dissolves faster (78.7%) than pure fenofibric acid (53.2%). after 60 minutes. Pharmacokinetic parameter determination tests showed no significant difference between pure fenofibric acid and solid dispersion. Solid dispersion of fenofibric acid with PEG 6000 as a carrier can improve the physicochemical performance and dissolution rate of fenofibric acid but pharmacokinetic parameters did not differ significantly.
Co-Authors Agistia, Nesa Amanda, Denisya Anggraini, Dhiva Annisa Annisa Armon Fernando Deni Anggraini Eliza Fitri Ezuela, Deska Z Idzan, Nur Kamilah K, Della Yunita Sary. Melzi Octaviani Safitri, Elsa Sari, Fatwa Aulia Sinata, Novia Yulia, Amanda