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All Journal INDONESIAN JOURNAL OF LEGAL AND FORENSIC SCIENCES Mutiara Medika: Jurnal Kedokteran dan Kesehatan
marsa, mardhatillah
Departemen Ilmu Kedokteran Forensik Dan Medikolegal FKKMK Universitas Gadjah Mada
Chemistry Dentistry Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology

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The Correlation of Cyp2e1 Genetic Polymorphism on Alcohol Drinking Habits in Papuan Ethnicity Mardhatillah Marsa; Yudha Nurhantari; Suhartini Suhartini; Tri Ratnaningsih
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 21, No 2 (2021): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v21i2.11579

Abstract

Alcohol abuse is associated with genetic factors and is influenced by certain races and ethnicities. CYP2E1, which works on the endoplasmic reticulum, produces an enzyme that plays a significant role in alcohol metabolism. In relation to it, this study aims to identify the polymorphisms of CYP2E1*5B and CYP2E1*6 genes in alcohol drinkers of Papuan Ethnics. A total of 39 Papuans were analyzed for alcohol drinking habits. Alcohol drinkers were found to be 29 people (74.4%), and 10 people (25.6%) were non-drinkers. The drinkers mainly were late teenagers (89,7%) and males (69,2%). The CYP2E1*5B genotypes were c1/c1 as 94.9% and c1/c2 as 5.1%. Meanwhile, the CYP2E1*6 T/T genotypes were 56.4%, and T/A genotypes were 43.6%. The odd ratio for CYP2E1*5B were 18,5 and 7,7 for CYP2E1*6. p0,05 for CYP2E1*5B and CYP2E1*6 gene polymorphisms for alcohol drinking behavior in the form of frequency, duration, type, and volume of alcohol consumed. Furthermore, c1/c1 and c1/c2 genotype polymorphisms were in CYP2E1*5B; T/T and T/A genotypes were in CYP2E1*6 of Papuan ethnic at Yogyakarta. In conclusion, genotype c1/c1 had 18,5 times of the possibility of being alcoholic drinkers, and genotype T/T had 7,7 times of the possibility of being alcoholic drinkers in Papuan ethnic. It indicated that the type of genotype statistically did not significantly affect alcohol drinking behavior on the subject.
PENENTUAN RUMUS TINGGI BADAN BERDASARKAN PANJANG JEJAK KAKI PADA ETNIS JAWA Mardhatillah Marsa; Yudha Nurhantari; Santosa Budiharjo
Indonesian Journal of Legal and Forensic Sciences (IJLFS) Vol 8 No 1 (2018): Indonesian Journal of Legal and Forensic Sciences
Publisher : Penerbit, sejak 2012 : Asosiasi Ilmu Forensik Indonesia dan UPT Lab. Forensik Sain dan Kriminilogi - Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/IJLFS.2018.v08.i01.p01

Abstract

Background: Proof of footprints in forensic identification can be used in the determination of personal identification, for example the height. Estimated the height is done by measuring the length of footprints. Based on the literature, height was correlates directly with long bones. Footprints are made by the soles of the feet that are part of the long bones. The calculation of the height is more accurate using the formula derived from the population concerned so that testing needs to be done on each population. Objective: To find out whether there is a correlation between the length of the footprint of a person's height, especially the Javanese ethnic population and determine the estimation formula of height based on the length of the footprint. Methods: The study subjects consisted of 100 men and 100 Javanese ethnic women aged 21-30 years who were taken by consecutive sampling technique. Measurements were made by measuring subject height and footprint imprint then calculated each of the length of right and left footprints. Result: The average height of male Javanese ethnic is 172,36 cm and woman 158,45 cm. The average length of right and left footprints in males is 23,02 cm and female 22 cm. Pearson correlation test on all subjects had r value of 0.968 for right footprint and r 0.967 for left footprint. On the male subject has r value 0.908 for right foot print and r 0.902 for left footprint. In the female subject has r value 0.927 for the right foot print and r 0.931 for the left footprint. Conclusion: There is a strong relationship between the length of a person's footprint with height and this study has earned a formula of height estimation based on the length of the footprint on the Javanese. Keywords: height, footprint, identification, Javanese ethnics
Co-Authors . Suhartini Santosa Budiharjo Tri Ratnaningsih Yudha Nurhantari