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All Journal E-Jurnal Medika Udayana Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Mutiara Medika: Jurnal Kedokteran dan Kesehatan Journal of Community Empowerment for Health Berita Kedokteran Masyarakat Jurnal Forensik dan Medikolegal Indonesia Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat

Yudha Nurhantari

Departemen Ilmu Kedokteran Forensik Dan Medikolegal, Fakultas Kedokteran, Kesehatan Masyarakat, Dan Keperawatan Universitas Gadjah Mada

Author-ID : 555233

Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Analysis of Enzyme Activity of Alcohol Dehydrogenase and Alcohol Dehydrogenase 3 (ADH3) Gene Polymorphism of Alcoholics and Non-Alcoholics in Indonesia. . Suhartini; . Mustofa; Yudha Nurhantari; Bambang Udji Djoko Rianto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 48, No 2 (2016)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

ABSTRACTAlcohol is an addictive substance that is often misused worldwide, including in Indonesia. Ninety percent of the alcohol that enters the body will be metabolized in the liver using the alcohol dehydrogenase (ADH) enzyme. It is important to determine the activity of ADH enzyme and ADH3 gene polymorphism on alcoholics and non-alcoholics in Yogyakarta, Indonesia. The aim of the study is to determine ADH activity and identify ADH3 gene polymorphism of alcoholics and non-alcoholics in Yogyakarta, Indonesia. This study was an observational study with a cross-sectional design method. Blood samples were taken from 71 Javanese alcoholics and 71 non-alcoholics of Javanese descent in Yogyakarta, Indonesia. The participants were initially requested to sign an informed consent form. Examination of ADH enzyme activity used the spectrophotometry method and ADH3 gene polymorphism was assessed with PCR-RFLP using Ssp I restriction enzyme. The activity of ADH enzyme in all individuals appeared to be a slower type. The average of the ethanol value of alcoholics and non-alcoholics were 0.05554 mM and 0.0758 mM respectively. Gene type of alcoholics were ADH3*2(75.4%), ADH3*1/3*2(21.5%), and ADH3*1(3.1%), and non-alcoholics were ADH3*2(88.6%), ADH3*1/3*2(10.0%), and ADH3*1(1.4%). There were no significant differences between the activity of ADH with polymorphism of ADH3 gene in either alcoholics and non-alcoholics (p>0,05). Conclusion: The activity of ADH enzyme in all participants appeared to be a slower type. Most of the ADH3 gene polymorphism of alcoholics and non-alcoholics were both ADH3*2 (75.4% and 88.6%). There was no differences of ADH enzyme activity with ADH3 gene polymorphism between alcoholics and non-alcoholics of Javanese population in Yogyakarta, Indonesia.

The analysis of cell damage of liver and kidney among alcoholics in Yogyakarta, Indonesia S Suhartini; Hendro Widagdo; Yudha Nurhantari; Idha Arfianti Wiraagni
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 3 (2019)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Alcohol tends to disrupt the organs function of human body, even can cause serious and chronic damage. In Indonesia, the data on cell damage taken from organs including the livers and kidneys among alcoholics are still practically unknown. The aim of this study was to compare the differences of organs’ cell disturbance between alcoholics and non-alcoholics in Yogyakarta, Indonesia. A crosssectional study was conducted among 197 people in Yogyakarta, including 96 alcoholics and 101 non-alcoholics. The material of the study was taken from venous blood samples. A kinetic photometric test was conducted to obtain data on blood-chemical markers’ value of livers (SGOT, SGPT, and GGT), and kidneys (BUN and serum creatinine). The data werethen analyzed by Chi square test.From a total of 96 alcoholics, 83.6% are males and 16.4% are females who consumed alcohol for an average of 16 years, with 51.6% routinely consuming it daily. The kind of alcohol they consumed was single-brand (59.8%). Based on 25th percentile (GGT), on 50th percentile (SGOT, GGT), and on 75th percentile (SGPT, GGT), the alcoholics had higher proportion value of liver marker disturbance than non-alcoholics which was statistically significant (p<0.05). Based on the 50th and 75th percentiles, the alcoholics also had higher proportion value on kidney marker (BUN) damage than non-alcoholics which was statistically significant (p<0.05). There were significant differences in GFR values between males and females (p<0.05), males had kidney cell damage 7.9 times more than females. There was no significant difference in the value of GFR between alcoholics and non-alcoholics. In conclusion, the alcoholics hassignificantly higher proportion value of blood-chemical markers than that non-alcoholics. The GFR values between males and females are also significantly different, and males had kidney cell damage 7.9 times more than that of females.

The Correlation of Cyp2e1 Genetic Polymorphism on Alcohol Drinking Habits in Papuan Ethnicity Mardhatillah Marsa; Yudha Nurhantari; Suhartini Suhartini; Tri Ratnaningsih
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 21, No 2 (2021): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v21i2.11579

Alcohol abuse is associated with genetic factors and is influenced by certain races and ethnicities. CYP2E1, which works on the endoplasmic reticulum, produces an enzyme that plays a significant role in alcohol metabolism. In relation to it, this study aims to identify the polymorphisms of CYP2E1*5B and CYP2E1*6 genes in alcohol drinkers of Papuan Ethnics. A total of 39 Papuans were analyzed for alcohol drinking habits. Alcohol drinkers were found to be 29 people (74.4%), and 10 people (25.6%) were non-drinkers. The drinkers mainly were late teenagers (89,7%) and males (69,2%). The CYP2E1*5B genotypes were c1/c1 as 94.9% and c1/c2 as 5.1%. Meanwhile, the CYP2E1*6 T/T genotypes were 56.4%, and T/A genotypes were 43.6%. The odd ratio for CYP2E1*5B were 18,5 and 7,7 for CYP2E1*6. p0,05 for CYP2E1*5B and CYP2E1*6 gene polymorphisms for alcohol drinking behavior in the form of frequency, duration, type, and volume of alcohol consumed. Furthermore, c1/c1 and c1/c2 genotype polymorphisms were in CYP2E1*5B; T/T and T/A genotypes were in CYP2E1*6 of Papuan ethnic at Yogyakarta. In conclusion, genotype c1/c1 had 18,5 times of the possibility of being alcoholic drinkers, and genotype T/T had 7,7 times of the possibility of being alcoholic drinkers in Papuan ethnic. It indicated that the type of genotype statistically did not significantly affect alcohol drinking behavior on the subject.

Karakteristik performance individu muda di Desa Ngablak dan hubungannya dengan penyalahgunaan NAPZA Suhartini Suhartini; Neni Trilusiana Rahmawati; Yudha Nurhantari; Hendro Widagdo; Idha Arfianti Wira Agni; Martiana Suciningtyas; Wikan Basworo
Journal of Community Empowerment for Health Vol 2, No 1 (2019)
Publisher : Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada

Alcohol, narcotics, psychotropic substances and other addictive substances are substances that are often misused. The majority of drug users are adolescents with age ranging from 13 - 17 years old at which abuse can affect body composition. Considering the role of the younger generation as the nation’s successors, it sparks the urgency to alleviate this negative behavior. One of the measures that can be done is by shifting the negative activities to positive ones such as sports. In order to do this, it is necessary to identify the performance characteristics of the youths to maximize their potential. This study aimed to find out the performance characteristics of the younger generation in Ngablak Village and their association with drug abuse. A total of 50 youth members in Ngablak Village, Ngablak Subdistrict, Magelang Regency were examined for anthropometry, physical (pulse, respiration rate, blood pressure, temperature), and somatotype associated with performance. Identification of subjects involved in alcohol and drug abuse was carried out using a questionnaire. The results were displayed descriptively. Statistical analyses (t-test or Mann Whitney U test) were used to compare performance characteristics between groups. Age of subjects ranged from 9 - 19 years and 50% were male. A total of 13 boys and 2 girls consumed alcohol. The results of physical examination showed the normal range in all subjetcs. The average age, height, and weight of male subjects who comsumed alcohol were higher than those who did not (p < 0,05). There was no difference in somatotype between adolescents who consumed alcohol and those who did not. The body type of male subjects based on measurements was the ideal type, whereas the female subjects had endomesomorphic body type. The tendency of consuming alcohol does not cause differences in body type in adolescents, both in male and female.

Karakteristik limbah dan dampaknya bagi kesehatan pembatik di Lendah, Kulon Progo Suhartini - suhartini; Sri Awalia Febriani; IBG. Surya Putra Pidada; Hendro Widagdo; Martiana Suciningtyas; Yudha Nurhantari; Dewanto Yusuf Priyambodo; Agus Surono; Roto Roto; Geraldine Nadita Putri Kinasih; Pramudji Hastuti; Sri Sutarni
Journal of Community Empowerment for Health Vol 2, No 2 (2019)
Publisher : Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jcoemph.42250

Synthetic batik coloring often uses heavy metals element such as lead (Pb), chromium (Cr),silica (Si), and hydrochloric acid (HCl). The exposure of heavy metals in long period results in health impair on the artisans and eventually harming the environment. The purpose of this research is to analyze the waste characteristics and health impact towards the artisans in the Lendah, Kulon Progo. Seventy-six batik artisan, consisting of 37 from SB, 20 from FA, and 19 from SA underwent 5 ml blood sampling. The samples were used to determine their hemoglobin (Hb) level, packed cell volume (PCV), blood sugar, and total cholesterol. Blood plasma and wastewater were examined for Pb and Cr using the inductively coupled plasma (ICP) method; Si using atomic absorption spectrophotometry (AAS); and Cl- using spectrophotometry. Respondents underwent health checks and were interviewed about the impact of waste and disease complaints experienced using a questionnaire. Cognitive disorders were examined using mini-mental state examination (MMSE) and peripheral neuropathy was assessed using diabetic neuropathy symptom (DNS) score. The results obtained were analyzed by analysis of variance and t-test. Correlation test was used to examine the relationship of Pb and Cr with cognitive disorders. Total cholesterol levels and blood sugar were analyzed descriptively. There is no difference in knowledge about waste in batik makers in SB, FA, and SA. The level of Pb, Cr, and Cl- within the three production centers showed no significant difference (p > 0,05), whilst Si level showed significant difference between centers (p < 0,05). There is no correlation between Pb and Cr blood levels with cognitive impairing according to MMSE and occurence of peripheral neuropathy according to DNS score (p > 0.05). Normal cholesterol levels (< 200mg/dL) andnormal blood glucose levels (< 200 mg/dL) were observed in 70.0-80.5% and 85.0-95.1% batik artisans, respectively. Si levels in all three production centers’ waste shows significant difference. The most frequent complaint was back pain and dizziness. There is no correlation caused by Pb and Cr levels toward cognitive impairing. Cholesterol level in batik artisans tended to be high.

Genetic polymorphism of ALDH2 linkage to kidney function status of East Nusa Tenggara alcohol drinkers and cigarette smokers Busyra Busyra; Yudha Nurhantari; Suhartini Suhartini; Maria Agnes Etty Dedy; Tri Ratnaningsih
Journal of Community Empowerment for Health Vol 4, No 2 (2021)
Publisher : Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jcoemph.61559

Chronic kidney disease is a preventable high-burden disease. Several risk factors for impaired kidney function have been identified, including lifestyles, such as alcohol drinking and cigarette smoking. However, the evidence remains inconsistent. East Nusa Tenggara has the largest proportion of heavy alcohol drinking among all provinces in Indonesia. Genetic polymorphism of aldehyde dehydrogenase 2 (ALDH2) is related to alcohol drinking behavior through the inactivity of the ALDH2 enzyme, which leads to toxic acetaldehyde accumulation. This study aims to recognize the linkage of ALDH2 genotypes to kidney function among alcohol drinkers and cigarette smokers in East Nusa Tenggara. This study was a cross-sectional study of East Nusa Tenggara ethnicity, aged 18-60 years old. Demographic and lifestyle data were obtained via a questionnaire. DNA analysis was conducted with the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Creatinine and BUN levels were measured with a chemistry analyzer. Afterward, the estimated glomerular filtration rate (eGFR) was calculated from creatinine value using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. The association between kidney function status and alcohol drinking and cigarette smoking habits were analyzed using the chi-square test, then stratified based on genotype groups. Fifty-one subjects were included in this study, while the mean age was 26.33±1.33 years and the median age was 22 years. There were 37 (72.5%) alcohol drinkers and 14 (27.5%) non-drinkers; 28 (54,9%) cigarette smokers and 23 (45.1%) non-smokers. This study revealed no significant association between kidney function status and alcohol drinking habits. Cigarette smoking habits were inversely associated with eGFR decline and creatinine elevation in wild-type ALDH2 groups.

Alcohol dehydrogenase 1C (ADH1C) polymorphism is significantly associated with kidney function status in Nusa Tenggara Timur ethnicity: A cross-sectional study Budiatri Retno Noormaningrum; Yudha Nurhantari; Suhartini Suhartini; Tri Ratnaningsih; Maria Agnes Etty Dedy
Journal of Community Empowerment for Health Vol 4, No 3 (2021)
Publisher : Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jcoemph.61561

Excessive alcohol consumption is harmful to many human organs, but the association with kidney function is still controversial. The disagreement in findings might be caused by ADH1C polymorphism's influence on alcohol metabolism rate. This study aims to determine the correlation between ADH1C polymorphism and kidney function status in Nusa Tenggara Timur (NTT) ethnicity, a population with highly prevalent alcohol consumption in Indonesia. We conducted a cross-sectional study of 76 subjects, who are natives of NTT, Indonesia. The genotyping of extracted DNA for ADH1C was done by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) using restriction endonuclease SspI. Kidney function status was defined by serum urea level and estimated glomerular filtration rate (eGFR) that had been categorized according to percentiles. The correlation with the ADH1C allele was analyzed using chi-square tests. The genotype of ADH1C in NTT ethnicity was ADH1C*1/*2 (51.3%), ADH1C*2/*2 (47.4%), and ADH1C*1/*1 (1.3%). The results showed that the population had the ADH1C*2 (73.03%) and the ADH1C*1 (26.97%) allele. There was a significant association between ADH1C polymorphism and eGFR among NTT ethnicity (p=0.005) when eGFR was analyzed at the 25th percentile (74.75 mL/minute/1.73m2). However, we found no associations when eGFR was analyzed at 50th (p=0.571) and 75th (p=0.335) percentiles. The odds ratio shows that having the ADH1C*1/*2 genotype escalates the probability of declining eGFR 6.620 times compared to ADH1C*2/*2 (95% CI: 1.539-28.478), after adjusted for smoking behavior. We found no association between ADH1C polymorphism and serum urea level (p=0.123, 0.421, and 0.335). The majority of NTT ethnicity have the ADH1C*1/*2 genotype. Populations with ADH1C*1/*2 have higher odds ratio for eGFR below 74.75 mL/minute/1.73m2 than those with ADH1C*2/*2 genotype. There was no association between ADH1C polymorphism and serum urea levels.

Hazard identification, risk assesment and risk control serta penerapan risk mapping pada rumah sakit hewan Prof. Soeparwi Universitas Gadjah Mada Pertiwi Pertiwi; Yudha Nurhantari; Santosa Budihardjo
Berita Kedokteran Masyarakat (BKM) Vol 35, No 2 (2019)
Publisher : Fakultas Kedokteran Universitas Gadjah Mada

Hazard identification, risk assesment and risk control and the application of risk mapping at Hospital of the Animal Prof. Soeparwi Universitas Gadjah Mada Purpose: This research was held to analyze the work accident using HIRARC method and the applied of Risk Mapping at the hospital of the animal of Prof. Soeparwi Gadjah Mada University, Yogyakarta.Method: This research used descriptive qualitative research method. The qualitative method used to describe the condition, assess, and to recognize the work accident analysis. The data used was grabbed from Hazard Identification Risk Assessment and Risk Control (HIRARC) method and questionnaire.Results: Hazard identification used HIRARC method at the hospital of the animal of Prof. Soeparwi Gadjah Mada University was about 198. The work hazard commonly includes physical hazard, chemistry, biologist, ergonomics, and psychosocial. The risk assessment which held denoted that there were 61 low risks, 108 medium risks, and 15 high risks. The recommendations of risk restraint that can be given were technician control, administrative, and the use of personal protective equipment (PPE).Conclusion: HIRARC method had been applied at the hospital of animal of Prof. Soeparwi with the result to that grooming unit was high risk work place, assessed with risk mapping. The risk was from animal contact phisically.

GENETIC POLYMORPHISM OF ALDEHYDE DEHYDROGENASE 2 (ALDH2) OF MINANGKABAU ETHNIC GROUP Hidayat, Taufik; Nurhantari, Yudha; Suhartini, .
E-Jurnal Medika Udayana Vol 12 No 6 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i06.P10

Introduction. Aldehyde dehydrogenase 2 (ALDH2) is the main isozymes that can converted efficiently acetaldehyde into acetic acid. The aim of this study is to analyze genetic polymorphism of ALDH2 of Minangkabau ethnic group and its relationship with alcohol sensitivity. Methode. This research use descriptive methodology. Population and sample taken from Minangkabau people who lived in Yogyakarta who passed the inclusion and exclusion criteria. Examination of polymorphism of ALDH2 was conducted to the sample with PCR-RFLP with Ear! Restriction enzyme. Results. From 24 electrophoresis samples we got genotype frequency of wild type is 5 samples (20.8%), heterozygote polymorphism is 16 samples (66.7%) and homozygote polymorphism/polymorphic type is 3 samples (12.5%). Conclusion. We conclude that there are heterozygote polymorphism and homozygote polymorphism in the young adult, non alcoholic and healthy Minangkabau ethnic group. Keywords: aldehyde dehydrogenase 2, polimorphism, Minangkabau ethnic

Hubungan Kadar Serum Glutamic Pyruvate Transaminase (SGPT) dan Serum Glutamic Oxaloacetic Transaminasi (SGOT) dengan Riwayat Konsumsi Alkohol Pada Etnis Papua Azizi, Biesta Adri; Nurhantari, Yudha; ., Suhartini; ., Triratnaningsih
Jurnal Forensik dan Medikolegal Indonesia Vol 4 No 1 (2023): Jurnal Forensik dan Medikolegal Indonesia
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jfmi.2023.4.1.7932

Tujuan penelitian ini adalah untuk mengetahui hubungan kadar SGPT dan SGOT dengan riwayat konsumsi alkohol pada etnis Papua Penelitian ini merupakan penelitian deskriptif analitik untuk mengetahui adanya hubungan antara riwayat konsumsi alkohol dengan kadar SGPT dan SGOT. Desain penelitian ini adalah cross sectional dan melibatkan 29 responden etnis Papua yang berdomisili di Yogyakarta. Sampel adalah darah yang didapatkan dari responden setelah dilakukan anamnesis, untuk diperiksa kadar SGPT dan SGOT. Analisis dilakukan menggunakan uji statistik chi-square dengan uji alternatif, Fisher’s exact test. Dari hasil analisis yang telah dilakukan menggunakan uji statistik chi-square, maka didapatkan bahwa tidak ada hubungan yang signifikan secara statistik (p > 0.05) antara kadar SGPT dan SGOT yang diperiksa dengan riwayat konsumsi alkohol pada etnis Papua. Tidak terdapat perbedaan proporsi yang bermakna antara individu etnis Papua yang memiliki riwayat konsumsi alkohol dan individu etnis Papua yang tidak memiliki riwayat konsumsi alkohol terhadap kadar SGPT dan SGOT, namun memiliki kecenderungan peningkatan kadar SGOT 2.567 kali lebih besar dibandingkan individu yang tidak memiliki riwayat konsumsi alkohol.

Co-Authors . Suhartini ., Triratnaningsih Agus Surono Azizi, Biesta Adri Bambang Udji Djoko Riyanto Budiatri Retno Noormaningrum Busyra Busyra Dewanto Yusuf Priyambodo Febriana, Sri Awalia Geraldine Nadita Putri Kinasih Hendro Widagdo Hendro Widagdo Hendro Widagdo I Gusti Wayan Murjana Yasa IBG. Surya Putra Pidada Idha Arfianti Wira Agni Kadarmo, Dhiwangkoro Aji Maria Agnes Etty Dedy marsa, mardhatillah Martiana Suciningtyas Martiana Suciningtyas Mustofa Mustofa Neni Trilusiana Rahmawati Neni Trilusiana Rahmawati Nila Nirmalasari Pertiwi Pertiwi Pramudji Hastuti Priambodo, Dewanto Yusuf Roto Roto Santosa Budihardjo Santosa Budiharjo Siregar, Lia Yulianti Sri Sutarni Suhartini ., Suhartini Suhartini Suhartini Suhartini Suhartini Suhartini, . Taufik Hidayat Tri Ratnaningsih Wikan Basworo Wiraagni, Idha Arfianti

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