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Hepatoprotective Activity of Ethanol Extract of Mobe Leaves (Artocarpus lacucha Buch-Ham.) on Total Bilirubin, ALT, and AST Levels, and Macropathology of Liver in Rats Induced by Carbon Tetrachloride Lubis, Meiva Amelia; Dalimunthe, Aminah; Sitorus, Panal; Satria, Denny; Lubis, Arga
Viva Medika Vol 17 No 3 (2024)
Publisher : LPPM Universitas Harapan Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35960/vm.v17i3.1490

Abstract

This study evaluates the hepatoprotective effects of ethanol extract of mobe leaves (Artocarpus lacucha Buch-Ham.) in rats induced with carbon tetrachloride (CCl4). The objective was to determine the extract's efficacy in reducing liver damage markers, specifically total bilirubin, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels, and to assess liver macropathology. The ethanol extract was prepared by maceration using 96% ethanol. Results showed that administering 400 mg/kg body weight (BW) of the extract significantly reduced total bilirubin, ALT, and AST levels in CCl4-induced rats. Additionally, liver macropathology observations indicated improved liver conditions in the treatment group. Phytochemical screening revealed bioactive compounds like flavonoids, alkaloids, tannins, saponins, triterpenoids, and glycosides, which are potential antioxidants and hepatoprotective agents. The significant contribution of this research is providing a scientific basis for using mobe leaf extract as a natural hepatoprotective agent, highlighting its potential for safe and effective herbal medicine. Further research and clinical trials are recommended to validate these findings and explore the extract's therapeutic applications.
CODE-MIXING AND LANGUAGE ATTITUDES IN JAPANESE CLASSROOMS: EVIDENCE FROM SENIOR SECONDARY SCHOOLS IN MEDAN Nelvita; Ilyas, Fauzan Azizi; Hidayat, M. Fachri; Lubis, Arga
Lire Journal (Journal of Linguistics and Literature) Vol. 10 No. 1 (2026): In Progress
Publisher : Elite Laboratory Jurusan Sastra Inggris Universitas Bangka Belitung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33019/lire.v10i1.601

Abstract

This study examines bilingualism and Indonesian–Japanese code-mixing among senior secondary school learners of Japanese in Medan, focusing on how these practices shape classroom learning under limited instructional exposure. This study aims to identify the frequency, types, and functions of code-mixing in classroom interaction, describe students’ language attitudes in terms of pride, loyalty, and norm awareness, and derive pedagogical implications for strengthening sustained Japanese output. A sociolinguistic mixed-methods design was employed, combining a 21-item questionnaire with participant observation and interviews. The sample consisted of 341 students from five schools. Quantitative data were analysed descriptively, while qualitative data were used to identify recurrent functional patterns of code-mixing across classroom activities. The findings argue that language pride toward Japanese was relatively high, particularly in polite greetings and in positive perceptions of the language’s future relevance. However, language loyalty in peer interaction remained low, and norm awareness was stronger in pragmatic politeness than in structural accuracy. Code-mixing primarily functioned as a practical resource for classroom management, meaning negotiation, and maintaining task flow. Therefore, we conclude that stronger Japanese output depends less on motivation alone than on instructional conditions that transform positive attitudes into stable speaking routines through structured communicative practice.