Article Per Year (5 Year)
p-Index From 2020 - 2025
0.61
P-Index
This Author published in this journals
All Journal Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan IJOEP : International Journal of Ecophysiology Asian Multidisciplinary Research Journal of Economy and Learning
Lubis, Meiva Amelia
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Humanities Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Other

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
Hepatoprotective effects of ethanol extract of mobe leaves/eeml (artocarpus lacucha buch-ham.) against carbon tetrachloride induced hepatotoxicity in rats: English Lubis, Meiva Amelia; Dalimunthe, Aminah; Sitorus, Panal; Satria, Denny
International Journal of Ecophysiology Vol. 6 No. 2 (2024): International Journal of Ecophysiology
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijoep.v6i2.17505

Abstract

This study evaluates the protective effects of ethanol extract of mobe leaves (Artocarpus lacucha Buch-Ham.) on ALT, AST, and bilirubin levels in rats induced with carbon tetrachloride (CCl4) on Liver. The ethanol extract was prepared by maceration using 96% ethanol. Results showed that administering 400 mg/kg BW of the extract significantly reduced total bilirubin, ALT, and AST levels in CCl4-induced rats. Phytochemical screening revealed bioactive compounds like flavonoids, alkaloids, tannins, saponins, triterpenoids, and glycosides, which are potential antioxidants and hepatoprotective agents. The study concludes that mobe leaf extract has potential as a therapeutic agent to protect the liver from toxic damage. The significant contribution of this research is providing a scientific basis for using mobe leaf extract as a natural hepatoprotective agent, highlighting its potential for safe and effective herbal medicine. Further research and clinical trials are recommended.
The Effect of Ethanol Extract of Mobe Leaves (Artocarpus lacucha Buch-Ham.) on Caspase-3 Expression in Liver Tissue Rats Induced by Carbon Tetrachloride: English Lubis, Meiva Amelia; Indah Pertiwi; Damayanti
Asian Multidisciplinary Research Journal of Economy and Learning Vol. 2 No. 7 (2025): July 2025
Publisher : CV. ARGA FARMA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70471/nvgf9h70

Abstract

Carbon tetrachloride (CCl₄) is a commonly used hepatotoxic agent to induce liver injury via oxidative stress and the activation of hepatocyte apoptosis. One hallmark of apoptosis is the increased expression of Caspase-3, a key executor enzyme in the programmed cell death pathway. The ethanol extract of Mobe leaves (Artocarpus lacucha Buch-Ham.) is known to contain bioactive compounds such as flavonoids and triterpenoids, which have demonstrated hepatoprotective potential. This study investigates the hepatoprotective effects of ethanol extract of Mobe leaves (EEML) on Caspase-3 expression in the liver tissues of rats induced by carbon tetrachloride. This experimental study utilized 30 male rats randomly assigned into six groups. The negative control group received CCl₄ - and CMC-Na 1%, while the positive control group received silymarin and CCl₄. Four treatment groups received oral doses of EEML at 50, 100, 200, and 400 mg/kg body weight for 15 days with CCl₄ induction. Caspase-3 expression in liver tissue was analyzed using the immunohistochemistry (IHC) method and quantified based on the number of positively stained cells across five microscopic fields. The results showed a significant reduction in Caspase-3 expression (p<0.05) in the EEML-treated groups compared to the negative control, with the 400 mg/kg dose achieving an effect comparable to silymarin. These findings suggest that EEML possesses hepatoprotective properties through apoptosis inhibition, evidenced by decreased Caspase-3 expression in CCl₄ injured liver tissue.
Hepatoprotective Activity of Ethanol Extract of Mobe Leaves (Artocarpus lacucha Buch-Ham.) on Total Bilirubin, ALT, and AST Levels, and Macropathology of Liver in Rats Induced by Carbon Tetrachloride Lubis, Meiva Amelia; Dalimunthe, Aminah; Sitorus, Panal; Satria, Denny; Lubis, Arga
Viva Medika Vol 17 No 3 (2024)
Publisher : Universitas Harapan Bangsa Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35960/vm.v17i3.1490

Abstract

This study evaluates the hepatoprotective effects of ethanol extract of mobe leaves (Artocarpus lacucha Buch-Ham.) in rats induced with carbon tetrachloride (CCl4). The objective was to determine the extract's efficacy in reducing liver damage markers, specifically total bilirubin, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels, and to assess liver macropathology. The ethanol extract was prepared by maceration using 96% ethanol. Results showed that administering 400 mg/kg body weight (BW) of the extract significantly reduced total bilirubin, ALT, and AST levels in CCl4-induced rats. Additionally, liver macropathology observations indicated improved liver conditions in the treatment group. Phytochemical screening revealed bioactive compounds like flavonoids, alkaloids, tannins, saponins, triterpenoids, and glycosides, which are potential antioxidants and hepatoprotective agents. The significant contribution of this research is providing a scientific basis for using mobe leaf extract as a natural hepatoprotective agent, highlighting its potential for safe and effective herbal medicine. Further research and clinical trials are recommended to validate these findings and explore the extract's therapeutic applications.
Co-Authors Aminah Dalimunthe Damayanti Denny Satria, Denny INDAH PERTIWI Lubis, Arga Sitorus, Panal