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All Journal Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan IJOEP : International Journal of Ecophysiology Journal of Pharmaceutical and Sciences. Asian Multidisciplinary Research Journal of Economy and Learning
Lubis, Meiva Amelia
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Hepatoprotective effects of ethanol extract of mobe leaves/eeml (artocarpus lacucha buch-ham.) against carbon tetrachloride induced hepatotoxicity in rats: English Lubis, Meiva Amelia; Dalimunthe, Aminah; Sitorus, Panal; Satria, Denny
International Journal of Ecophysiology Vol. 6 No. 2 (2024): International Journal of Ecophysiology
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijoep.v6i2.17505

Abstract

This study evaluates the protective effects of ethanol extract of mobe leaves (Artocarpus lacucha Buch-Ham.) on ALT, AST, and bilirubin levels in rats induced with carbon tetrachloride (CCl4) on Liver. The ethanol extract was prepared by maceration using 96% ethanol. Results showed that administering 400 mg/kg BW of the extract significantly reduced total bilirubin, ALT, and AST levels in CCl4-induced rats. Phytochemical screening revealed bioactive compounds like flavonoids, alkaloids, tannins, saponins, triterpenoids, and glycosides, which are potential antioxidants and hepatoprotective agents. The study concludes that mobe leaf extract has potential as a therapeutic agent to protect the liver from toxic damage. The significant contribution of this research is providing a scientific basis for using mobe leaf extract as a natural hepatoprotective agent, highlighting its potential for safe and effective herbal medicine. Further research and clinical trials are recommended.
The Effect of Ethanol Extract of Mobe Leaves (Artocarpus lacucha Buch-Ham.) on Caspase-3 Expression in Liver Tissue Rats Induced by Carbon Tetrachloride: English Lubis, Meiva Amelia; Indah Pertiwi; Damayanti
Asian Multidisciplinary Research Journal of Economy and Learning Vol. 2 No. 7 (2025): July 2025
Publisher : CV. ARGA FARMA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70471/nvgf9h70

Abstract

Carbon tetrachloride (CCl₄) is a commonly used hepatotoxic agent to induce liver injury via oxidative stress and the activation of hepatocyte apoptosis. One hallmark of apoptosis is the increased expression of Caspase-3, a key executor enzyme in the programmed cell death pathway. The ethanol extract of Mobe leaves (Artocarpus lacucha Buch-Ham.) is known to contain bioactive compounds such as flavonoids and triterpenoids, which have demonstrated hepatoprotective potential. This study investigates the hepatoprotective effects of ethanol extract of Mobe leaves (EEML) on Caspase-3 expression in the liver tissues of rats induced by carbon tetrachloride. This experimental study utilized 30 male rats randomly assigned into six groups. The negative control group received CCl₄ - and CMC-Na 1%, while the positive control group received silymarin and CCl₄. Four treatment groups received oral doses of EEML at 50, 100, 200, and 400 mg/kg body weight for 15 days with CCl₄ induction. Caspase-3 expression in liver tissue was analyzed using the immunohistochemistry (IHC) method and quantified based on the number of positively stained cells across five microscopic fields. The results showed a significant reduction in Caspase-3 expression (p<0.05) in the EEML-treated groups compared to the negative control, with the 400 mg/kg dose achieving an effect comparable to silymarin. These findings suggest that EEML possesses hepatoprotective properties through apoptosis inhibition, evidenced by decreased Caspase-3 expression in CCl₄ injured liver tissue.
Hepatoprotective Activity of Ethanol Extract of Mobe Leaves (Artocarpus lacucha Buch-Ham.) on Total Bilirubin, ALT, and AST Levels, and Macropathology of Liver in Rats Induced by Carbon Tetrachloride Lubis, Meiva Amelia; Dalimunthe, Aminah; Sitorus, Panal; Satria, Denny; Lubis, Arga
Viva Medika Vol 17 No 3 (2024)
Publisher : LPPM Universitas Harapan Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35960/vm.v17i3.1490

Abstract

This study evaluates the hepatoprotective effects of ethanol extract of mobe leaves (Artocarpus lacucha Buch-Ham.) in rats induced with carbon tetrachloride (CCl4). The objective was to determine the extract's efficacy in reducing liver damage markers, specifically total bilirubin, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels, and to assess liver macropathology. The ethanol extract was prepared by maceration using 96% ethanol. Results showed that administering 400 mg/kg body weight (BW) of the extract significantly reduced total bilirubin, ALT, and AST levels in CCl4-induced rats. Additionally, liver macropathology observations indicated improved liver conditions in the treatment group. Phytochemical screening revealed bioactive compounds like flavonoids, alkaloids, tannins, saponins, triterpenoids, and glycosides, which are potential antioxidants and hepatoprotective agents. The significant contribution of this research is providing a scientific basis for using mobe leaf extract as a natural hepatoprotective agent, highlighting its potential for safe and effective herbal medicine. Further research and clinical trials are recommended to validate these findings and explore the extract's therapeutic applications.
Efek Ekstrak Etanol Daun Mobe (Artocarpus lacucha Buch-Ham.) terhadap Histopatologi Hati Tikus Diinduksi Karbon Tetraklorida Lubis, Meiva Amelia; Dalimunthe , Aminah; Sitorus , Panal; Satria , Denny; Pertiwi , Indah; Damayanti S , Damayanti S
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1432

Abstract

Background: Liver injury due to exposure to hepatotoxic chemicals remains a major problem in the medical and pharmaceutical fields. Carbon tetrachloride (CCl₄) is a classic hepatotoxic agent that induces oxidative stress, lipid peroxidation, and hepatocyte necrosis through free radical formation. Mobe leaves (Artocarpus lacucha Buch-Ham.) contain bioactive compounds, particularly flavonoids and phenolics, which possess antioxidant and anti-inflammatory properties with potential hepatoprotective effects. Objective: This study aimed to evaluate the effect of ethanol extract of mobe leaves (EEML) on the liver histopathology of rats induced with carbon tetrachloride. Methods: This experimental study used a post-test only control group design. Twenty-five male rats were divided into five groups: negative control (CMC-Na 1% + CCl₄), positive control (silymarin 100 mg/kgBW + CCl₄), and three treatment groups receiving EEML at doses of 50, 100, and 200 mg/kgBW + CCl₄. Hepatotoxicity was induced by intraperitoneal injection of CCl₄ (1 mL/kgBW) twice weekly for 14 days. Liver tissue was processed for hematoxylin-eosin staining, and histopathological changes (hepatocyte degeneration, necrosis, and inflammatory cell infiltration) were assessed semi-quantitatively using a scoring system (0-3). Results: CCl₄ induction caused severe liver damage in the negative control group, characterized by diffuse hydropic degeneration, extensive necrosis, and marked inflammatory infiltration (score 3 for all parameters). EEML administration significantly reduced liver injury in a dose-dependent manner. The 200 mg/kgBW dose showed the most pronounced hepatoprotective effect, with degeneration score 2, necrosis score 1, and inflammation score 2, approaching the protective effect of silymarin (score 1 for all parameters). Conclusion: Ethanol extract of mobe leaves demonstrated hepatoprotective activity against CCl₄-induced liver damage in rats, with the optimal effect at 200 mg/kgBW. These findings support the potential of mobe leaves as a natural hepatoprotective agent.
Co-Authors Aminah Dalimunthe Dalimunthe , Aminah Damayanti Damayanti S , Damayanti S Denny Satria, Denny INDAH PERTIWI Lubis, Arga Pertiwi , Indah Satria , Denny Sitorus , Panal Sitorus, Panal