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All Journal Mestaka: Jurnal Pengabdian Kepada Masyarakat Journal of Medicine and Health
Syafira, Mutia
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Agriculture, Biological Sciences & Forestry Humanities Energy Environmental Science Languange, Linguistic, Communication & Media Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences Other

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SYSTEMATIC REVIEW: PEMODIFIKASI GENETIK β-THALASSEMIA Syafira, Mutia; Sribudiani, Yunia; Maskoen, Ani M
Journal of Medicine and Health Vol 6 No 1 (2024)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v6i1.4788

Abstract

Thalassemia merupakan penyakit herediter yang diturunkan secara autosomal resesif. Thalassemia dibedakan berdasarkan variasi mutasi pada gen globin yaitu gen α-globin (HBA) pada α-Thalassemia dan β-globin (HBB) pada β-Thalassemia. Penelitian ini bertujuan untuk mengetahui potensi pemodifikasi genetik pada penderita β-Thalassemia. Data sistimatika review dengan pengumpulan jurnal terkait pada cangkupan kata kunci yang dikomplikasikan prinsip PRISMA. Beberapa hasil studi melaporkan polimorfisme dan atau mutasi pada gen KLF1, BCL11A dan region intergenik HBS1L-MYB sebagai pemodifikasi genetik pada β-Thalassemia, didapatkan sembilan jurnal yang masuk ke dalam kriteria inklusi. Berdasarkan hasil review yang dapat ditelaah bahwa pemodifikasi genetik pada kasus β-Thalassemia diketahui adanya mutasi atau polimorfisme pada gen-gen berikut KLF1, BCL11A, dan HBS1L-MYB cenderung meningkatkan produksi HbF dengan mengatur ekspresi γ-globin dan memperbaiki gejala klinis pasien β-Thalassemia. Simpulan dari kasus tersebut menjadikan peluang di kemudian hari untuk perawatan pasien yang dipersonalisasi disesuaikan dengan fenotipe yang meringankan gejala penderita β-Thalassemia.
Sosialisasi dan Edukasi Pemanfaatan Platelet Rich Plasma (PRP) Metode Nebulisasi pada Paguyuban Lansia PMI Kota Semarang Syafira, Mutia; Anzhari, Della Hashfi; Ariani, Resti; Hastuti, Diah; Shafira, Chintya Meiska; Amirullah, Nafissa Naomi
Mestaka: Jurnal Pengabdian Kepada Masyarakat Vol. 5 No. 1 (2026): Februari 2026
Publisher : Pakis Journal Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58184/mestaka.v5i1.865

Abstract

Based on the results of initial observations conducted with activity partners, it was found that the Semarang City PMI Elderly Association still has limited knowledge regarding innovations in the use of blood-based products, especially Platelet Rich Plasma (PRP), and its application methods in the health sector. The lack of information that is easily understood by the elderly group is one of the factors in low health literacy regarding the development of blood-based health technology. This community service activity aims to socialize and educate the Semarang City PMI Elderly Association regarding the concept, benefits, and basic principles of the use of Platelet Rich Plasma (PRP) with the nebulization method. The activity was implemented through educational and interactive material delivery, discussions, and evaluation of participant understanding. Based on the results of the community service activity, participants showed high enthusiasm and consistent attendance during the socialization process, marked by active participation in discussions and increased understanding of the material presented. This activity can be concluded as running well and showing a better understanding based on qualitative analysis and elderly awareness of the innovation of PRP use as part of health education. This community service activity is expected to support the role of universities in the implementation of Tridarma, especially community service in the health sector.
Co-Authors Amirullah, Nafissa Naomi Ani M Maskoen, Ani M Anzhari, Della Hashfi Ariani, Resti Hastuti, Diah Shafira, Chintya Meiska Sribudiani, Yunia