Obesity is a growing public health issue, particularly among young adults such as university students. Lifestyle changes characterized by high consumption of fast food and low levels of physical activity are major contributing factors to the increasing prevalence of obesity. This study aimed to examine the relationship between fast food consumption habits and physical activity levels with the incidence of obesity among students of the Pharmacy Study Program at Medistra Health Institute, Lubuk Pakam. This research employed an analytical observational design with a cross-sectional approach. The sample consisted of 59 students, selected using a simple random sampling technique. Data were collected using a Food Frequency Questionnaire (FFQ) to assess fast food consumption habits, physical activity questionnaires to determine activity levels, and waist circumference measurements as an indicator of central obesity. Data were analyzed using the Spearman rho correlation test with a significance level of p < 0.05. The results showed a significant relationship between fast food consumption habits (r = 0.596; p < 0.05) and physical activity (r = 0.389; p < 0.05) with obesity incidence among students. The findings indicate that students who frequently consume fast food and engage in low levels of physical activity are at a higher risk of developing obesity. In conclusion, unhealthy eating patterns and sedentary lifestyles are key factors contributing to obesity among young adults; therefore, preventive efforts through nutrition education and the promotion of regular physical activity are necessary within the university environment.