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All Journal Jurnal Ilmiah Farmasi Journal of Pharmaceutical and Sciences.
Hayati , Risda
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Potensi kemopreventif fraksi n-heksan biji kebiul (Caesalpinia bonduc (L) Roxb.) Bengkulu pada chorioallantoic membrane yang diinduksi bFGF Hayati , Risda; Nadia, Nadia; Karini , Amey Putri; Shavitry, Ayyu; Romdani, Ayu Nadiyah Permatasari; Wulandari, Septi
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.333

Abstract

Cancer is the growth or swelling of a mass of abnormal, uncontrolled and malignant cells. With the formation of these blood vessels, antiangiogenesis is needed because without a blood supply, cancer cells will die. The kebiul seed plant (Caesalpinia bonduc (L) Roxb.) contains secondary metabolites as anticancer. This research uses experimental methods, namely making N-Hexane extracts and fractions, Phytochemical Tests, and Antiangiogenesis Tests. The yield of kebiul seeds was 13.608%. In the phytochemical test, the n-hexane fraction of kebiul seeds gave positive results for alkaloids, flavonoids, triterpenoids and tannins. In the blank paper disc group, paper discs with DMSO solvent and paper discs induced by bFGF the average score was 0 (not active). The N-Hexane fraction with a concentration of 02 mg/ml is the most active and has the greatest and best antiangiogenesis effect with an average score of 1.66 (Good), at a concentration of 0.1 mg/ml with an average score of 1.33 (good) and at a concentration of 0.05 mg/ml with an average score of 0.83 (weak). Macroscopic observations showed that kebiul seed extract inhibited the growth of new blood vessels in the bFGF-induced CAM of chicken embryos depending on the concentration given.
Antioxidant and antiangiogenic potential of kebiul (Caesalpinia bonduc (L) Roxb.) from South Bengkulu as a chemopreventive agent Wulandari, Septi; Wibowo, Risky Hadi; Nurwidiyani, Ria; Hayati , Risda; Nadia; Putri , Amey
Jurnal Ilmiah Farmasi Vol. 22 No. 1 (2026): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol22.iss1.art8

Abstract

Background: Kebiul seeds are an Indonesian medicinal plant with potential antioxidant and chemopreventive properties against cancer. The development, growth, and invasion of malignant cancer closely link to angiogenesis, which antioxidant effects can influence.Objective: This study aims to evaluate the antioxidant activity of kebiul seeds based on the IC50 and their anti-angiogenesis effects.Method: Extraction was performed using the maceration method using ethyl acetate, n-hexane, and ethanol. The anti-angiogenesis test was conducted using the chorioallantoic membrane (CAM) method, while the antioxidant activity was assessed using the diphenylpyrrolhydrazyl (DPPH) method.Results: The finding revealed the antioxidant activity values, as indicated by the IC50, were 45.225 ppm for the ethanol extract (strong antioxidant), 86.190 ppm for the n-hexane extract (strong antioxidant), and 146 ppm for the ethyl acetate extract (medium antioxidant). Anti-angiogenesis tests were conducted across various solvents and concentrations. Significant anti-angiogenesis effects were observed at concentrations of 10, 50, and 1000 ppm. The n-hexane extract yielded average scores of 0.33, 0.66, and 1.3, indicating a good effect. The ethyl acetate extract had average scores of 0.33, 0.5, and 0.66, suggesting a weak effect, while the ethanol extract showed mean scores of 1.33, 1.66, and 2, indicating a strong effect. Conclusion: Ethanol extract demonstrates the most potential as a chemopreventive agent.
Co-Authors Karini , Amey Putri Nadia Nadia Nadia Nurwidiyani, Ria Putri , Amey Romdani, Ayu Nadiyah Permatasari SEPTI WULANDARI Shavitry, Ayyu Wibowo, Risky Hadi